The myelin proteins of the shark brain are similar to the myelin proteins of the mammalian peripheral nervous system

The two major structural proteins in the shark CNS are similar to the structural proteins, Po and myelin basic protein (MBP), found in the mammalian peripheral nervous system (PNS). Shark Po is 46% similar to its mammalian counterpart. The extracellular domain of shark Po also appears to be organize...

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Veröffentlicht in:Journal of molecular evolution 1989-08, Vol.29 (2), p.149-156
Hauptverfasser: SAAVEDRA, R. A, FORS, L, AEBERSOLD, R. H, ARDEN, B, HORWATH, S, SANDERS, J, HOOD, L
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container_end_page 156
container_issue 2
container_start_page 149
container_title Journal of molecular evolution
container_volume 29
creator SAAVEDRA, R. A
FORS, L
AEBERSOLD, R. H
ARDEN, B
HORWATH, S
SANDERS, J
HOOD, L
description The two major structural proteins in the shark CNS are similar to the structural proteins, Po and myelin basic protein (MBP), found in the mammalian peripheral nervous system (PNS). Shark Po is 46% similar to its mammalian counterpart. The extracellular domain of shark Po also appears to be organized as an immunoglobulin-like domain that mediates homotypic interactions. The intracellular domain of shark Po also is very basic and may play a role in myelin condensation analogous to that of MBP. Shark MBP is 44% similar to mammalian MBP. Both MBPs show conserved interspersed regions and are present in multiple forms that arise by alternative splicing of a single transcript. These structural analyses indicate that the complexities seen in mammalian myelin arose early during vertebrate evolution.
doi_str_mv 10.1007/bf02100113
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subjects Amino Acid Sequence
Animals
Base Sequence
Biological and medical sciences
Biological evolution
Brain - metabolism
Cloning, Molecular
DNA - genetics
Fundamental and applied biological sciences. Psychology
Genes
Genetics of eukaryotes. Biological and molecular evolution
Membrane Glycoproteins - genetics
Mice - genetics
Molecular Sequence Data
myelin basic protein
Myelin Basic Protein - genetics
Myelin P0 Protein
Myelin Proteins - genetics
Oligonucleotide Probes
Peripheral Nerves - metabolism
Protein Conformation
Rats - genetics
Selachii
Sequence Homology, Nucleic Acid
Sharks - genetics
Species Specificity
Spinal Cord - metabolism
title The myelin proteins of the shark brain are similar to the myelin proteins of the mammalian peripheral nervous system
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