The myelin proteins of the shark brain are similar to the myelin proteins of the mammalian peripheral nervous system
The two major structural proteins in the shark CNS are similar to the structural proteins, Po and myelin basic protein (MBP), found in the mammalian peripheral nervous system (PNS). Shark Po is 46% similar to its mammalian counterpart. The extracellular domain of shark Po also appears to be organize...
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Veröffentlicht in: | Journal of molecular evolution 1989-08, Vol.29 (2), p.149-156 |
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container_title | Journal of molecular evolution |
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creator | SAAVEDRA, R. A FORS, L AEBERSOLD, R. H ARDEN, B HORWATH, S SANDERS, J HOOD, L |
description | The two major structural proteins in the shark CNS are similar to the structural proteins, Po and myelin basic protein (MBP), found in the mammalian peripheral nervous system (PNS). Shark Po is 46% similar to its mammalian counterpart. The extracellular domain of shark Po also appears to be organized as an immunoglobulin-like domain that mediates homotypic interactions. The intracellular domain of shark Po also is very basic and may play a role in myelin condensation analogous to that of MBP. Shark MBP is 44% similar to mammalian MBP. Both MBPs show conserved interspersed regions and are present in multiple forms that arise by alternative splicing of a single transcript. These structural analyses indicate that the complexities seen in mammalian myelin arose early during vertebrate evolution. |
doi_str_mv | 10.1007/bf02100113 |
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Biological and molecular evolution ; Membrane Glycoproteins - genetics ; Mice - genetics ; Molecular Sequence Data ; myelin basic protein ; Myelin Basic Protein - genetics ; Myelin P0 Protein ; Myelin Proteins - genetics ; Oligonucleotide Probes ; Peripheral Nerves - metabolism ; Protein Conformation ; Rats - genetics ; Selachii ; Sequence Homology, Nucleic Acid ; Sharks - genetics ; Species Specificity ; Spinal Cord - metabolism</subject><ispartof>Journal of molecular evolution, 1989-08, Vol.29 (2), p.149-156</ispartof><rights>1989 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c408t-ef576a746d97dc39788f917fb99990e2ba53dfc782d8f6833fab220145baf3d73</citedby><cites>FETCH-LOGICAL-c408t-ef576a746d97dc39788f917fb99990e2ba53dfc782d8f6833fab220145baf3d73</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=7329081$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/2478717$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>SAAVEDRA, R. 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Biological and molecular evolution</subject><subject>Membrane Glycoproteins - genetics</subject><subject>Mice - genetics</subject><subject>Molecular Sequence Data</subject><subject>myelin basic protein</subject><subject>Myelin Basic Protein - genetics</subject><subject>Myelin P0 Protein</subject><subject>Myelin Proteins - genetics</subject><subject>Oligonucleotide Probes</subject><subject>Peripheral Nerves - metabolism</subject><subject>Protein Conformation</subject><subject>Rats - genetics</subject><subject>Selachii</subject><subject>Sequence Homology, Nucleic Acid</subject><subject>Sharks - genetics</subject><subject>Species Specificity</subject><subject>Spinal Cord - metabolism</subject><issn>0022-2844</issn><issn>1432-1432</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1989</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkc1LwzAYh4Moc04v3oUcxINQzVeX5KjDqTDwMs_lbZuwaNPOpBP235u56k3MIV_Pk5cfeRE6p-SGEiJvS0tY2lDKD9CYCs6y3XSIxoQwljElxDE6ifEtKTLXfIRGTEglqRyjfrky2G9N41q8Dl1vXBtxZ3GfruMKwjsuAyQGIZ2ddw0E3Hff-I9XHryHxkEiJrj1ygRocGvCZ7eJOG5jb_wpOrLQRHM2rBP0On9Yzp6yxcvj8-xukVWCqD4zNpdTkGJaa1lXXEulrKbSljoNYlgJOa9tJRWrlZ0qzi2UjBEq8hIsryWfoKt93ZTxY2NiX3gXK9M00JqUppCaacI1-1ekuZhKonUSr_diFboYg7HFOjgPYVtQUux6UdzPf3qR5Iuh6qb0pv5Vh89P_HLgECtobIC2cvFXkzylU5R_AXy0kbo</recordid><startdate>198908</startdate><enddate>198908</enddate><creator>SAAVEDRA, R. 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Biological and molecular evolution</topic><topic>Membrane Glycoproteins - genetics</topic><topic>Mice - genetics</topic><topic>Molecular Sequence Data</topic><topic>myelin basic protein</topic><topic>Myelin Basic Protein - genetics</topic><topic>Myelin P0 Protein</topic><topic>Myelin Proteins - genetics</topic><topic>Oligonucleotide Probes</topic><topic>Peripheral Nerves - metabolism</topic><topic>Protein Conformation</topic><topic>Rats - genetics</topic><topic>Selachii</topic><topic>Sequence Homology, Nucleic Acid</topic><topic>Sharks - genetics</topic><topic>Species Specificity</topic><topic>Spinal Cord - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>SAAVEDRA, R. A</creatorcontrib><creatorcontrib>FORS, L</creatorcontrib><creatorcontrib>AEBERSOLD, R. 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A</au><au>FORS, L</au><au>AEBERSOLD, R. H</au><au>ARDEN, B</au><au>HORWATH, S</au><au>SANDERS, J</au><au>HOOD, L</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The myelin proteins of the shark brain are similar to the myelin proteins of the mammalian peripheral nervous system</atitle><jtitle>Journal of molecular evolution</jtitle><addtitle>J Mol Evol</addtitle><date>1989-08</date><risdate>1989</risdate><volume>29</volume><issue>2</issue><spage>149</spage><epage>156</epage><pages>149-156</pages><issn>0022-2844</issn><eissn>1432-1432</eissn><coden>JMEVAU</coden><abstract>The two major structural proteins in the shark CNS are similar to the structural proteins, Po and myelin basic protein (MBP), found in the mammalian peripheral nervous system (PNS). Shark Po is 46% similar to its mammalian counterpart. The extracellular domain of shark Po also appears to be organized as an immunoglobulin-like domain that mediates homotypic interactions. 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subjects | Amino Acid Sequence Animals Base Sequence Biological and medical sciences Biological evolution Brain - metabolism Cloning, Molecular DNA - genetics Fundamental and applied biological sciences. Psychology Genes Genetics of eukaryotes. Biological and molecular evolution Membrane Glycoproteins - genetics Mice - genetics Molecular Sequence Data myelin basic protein Myelin Basic Protein - genetics Myelin P0 Protein Myelin Proteins - genetics Oligonucleotide Probes Peripheral Nerves - metabolism Protein Conformation Rats - genetics Selachii Sequence Homology, Nucleic Acid Sharks - genetics Species Specificity Spinal Cord - metabolism |
title | The myelin proteins of the shark brain are similar to the myelin proteins of the mammalian peripheral nervous system |
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