Survival Rate in Children with Fulminant Hepatitis Improved by a Combination of Twice Daily Plasmapheresis and Intensive Conservative Therapy
Six of seven children with fulminant hepatitis (FH) were treated with a combination of twice daily plasmapheresis and intensive conservative therapy including special amino acid solution, glucagon-insulin therapy, dexamethasone, and so on. The remaining child was treated with intensive conservative...
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| Veröffentlicht in: | Journal of pediatric gastroenterology and nutrition 1989-08, Vol.9 (2), p.163-166 |
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| container_title | Journal of pediatric gastroenterology and nutrition |
| container_volume | 9 |
| creator | Shin, Kenji Nagai, Yoji Hirano, Chiaki Kataoka, Natsue Ono, Ichiro Yamamura, Eiji Moriyama, Chiaki Horigome, Yumi Ehara, Takao Kamoda, Tomohiro Sumazaki, Ryo Hanada, Takashi Hamano, Kenzo Ogata, Takesaburo Takita, Hitoshi |
| description | Six of seven children with fulminant hepatitis (FH) were treated with a combination of twice daily plasmapheresis and intensive conservative therapy including special amino acid solution, glucagon-insulin therapy, dexamethasone, and so on. The remaining child was treated with intensive conservative therapy only because his condition was not so severe, in spite of being diagnosed as having fulminant hepatitis. Although five patients with biopsy-documented bridging hepatic necrosis or confluent hepatic necrosis in the acute phase made recoveries, the remaining two with massive hepatic necrosis died (the overall survival rate was 71%). The prognostic factors were considered to be the degree and pattern of liver cell necrosis, the degree of coma, and the etiology. The combination of twice daily plasmapheresis and intensive conservative therapy was effective for these pediatric patients with fulminant hepatitis, except those with massive hepatic necrosis. |
| doi_str_mv | 10.1097/00005176-198908000-00005 |
| format | Article |
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The remaining child was treated with intensive conservative therapy only because his condition was not so severe, in spite of being diagnosed as having fulminant hepatitis. Although five patients with biopsy-documented bridging hepatic necrosis or confluent hepatic necrosis in the acute phase made recoveries, the remaining two with massive hepatic necrosis died (the overall survival rate was 71%). The prognostic factors were considered to be the degree and pattern of liver cell necrosis, the degree of coma, and the etiology. The combination of twice daily plasmapheresis and intensive conservative therapy was effective for these pediatric patients with fulminant hepatitis, except those with massive hepatic necrosis.</description><identifier>ISSN: 0277-2116</identifier><identifier>EISSN: 1536-4801</identifier><identifier>DOI: 10.1097/00005176-198908000-00005</identifier><identifier>PMID: 2509666</identifier><identifier>CODEN: JPGND6</identifier><language>eng</language><publisher>Hagerstown, MD: Lippincott-Raven Publishers</publisher><subject>Acute Disease ; Biological and medical sciences ; Child ; Child, Preschool ; Combined Modality Therapy ; Evaluation Studies as Topic ; Female ; Hepatic Encephalopathy - mortality ; Hepatic Encephalopathy - therapy ; Hepatitis - mortality ; Hepatitis - therapy ; Human viral diseases ; Humans ; Infant ; Infectious diseases ; Male ; Medical sciences ; Parenteral Nutrition ; Plasmapheresis - methods ; Survival Rate ; Viral diseases ; Viral hepatitis</subject><ispartof>Journal of pediatric gastroenterology and nutrition, 1989-08, Vol.9 (2), p.163-166</ispartof><rights>Lippincott-Raven Publishers.</rights><rights>1990 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4345-2a18f3d084b6560e0ba283b46f952ef6804dee53a9f0bc30ecc7d0b835ef32d63</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=6848900$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/2509666$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Shin, Kenji</creatorcontrib><creatorcontrib>Nagai, Yoji</creatorcontrib><creatorcontrib>Hirano, Chiaki</creatorcontrib><creatorcontrib>Kataoka, Natsue</creatorcontrib><creatorcontrib>Ono, Ichiro</creatorcontrib><creatorcontrib>Yamamura, Eiji</creatorcontrib><creatorcontrib>Moriyama, Chiaki</creatorcontrib><creatorcontrib>Horigome, Yumi</creatorcontrib><creatorcontrib>Ehara, Takao</creatorcontrib><creatorcontrib>Kamoda, Tomohiro</creatorcontrib><creatorcontrib>Sumazaki, Ryo</creatorcontrib><creatorcontrib>Hanada, Takashi</creatorcontrib><creatorcontrib>Hamano, Kenzo</creatorcontrib><creatorcontrib>Ogata, Takesaburo</creatorcontrib><creatorcontrib>Takita, Hitoshi</creatorcontrib><title>Survival Rate in Children with Fulminant Hepatitis Improved by a Combination of Twice Daily Plasmapheresis and Intensive Conservative Therapy</title><title>Journal of pediatric gastroenterology and nutrition</title><addtitle>J Pediatr Gastroenterol Nutr</addtitle><description>Six of seven children with fulminant hepatitis (FH) were treated with a combination of twice daily plasmapheresis and intensive conservative therapy including special amino acid solution, glucagon-insulin therapy, dexamethasone, and so on. The remaining child was treated with intensive conservative therapy only because his condition was not so severe, in spite of being diagnosed as having fulminant hepatitis. Although five patients with biopsy-documented bridging hepatic necrosis or confluent hepatic necrosis in the acute phase made recoveries, the remaining two with massive hepatic necrosis died (the overall survival rate was 71%). The prognostic factors were considered to be the degree and pattern of liver cell necrosis, the degree of coma, and the etiology. The combination of twice daily plasmapheresis and intensive conservative therapy was effective for these pediatric patients with fulminant hepatitis, except those with massive hepatic necrosis.</description><subject>Acute Disease</subject><subject>Biological and medical sciences</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>Combined Modality Therapy</subject><subject>Evaluation Studies as Topic</subject><subject>Female</subject><subject>Hepatic Encephalopathy - mortality</subject><subject>Hepatic Encephalopathy - therapy</subject><subject>Hepatitis - mortality</subject><subject>Hepatitis - therapy</subject><subject>Human viral diseases</subject><subject>Humans</subject><subject>Infant</subject><subject>Infectious diseases</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Parenteral Nutrition</subject><subject>Plasmapheresis - methods</subject><subject>Survival Rate</subject><subject>Viral diseases</subject><subject>Viral hepatitis</subject><issn>0277-2116</issn><issn>1536-4801</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1989</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1ksFu1DAQhi1EVZbCIyD5gLgF7Dh2nCNaKF2pEqhdztEkmSgGxwm2k9U-BO9cwy57w5fRzHz_WJ7fhFDO3nNWlR9YOpKXKuOVrphOWfa39IxsuBQqKzTjz8mG5WWZ5ZyrF-RlCD8SURaSXZPrXLJKKbUhvx8Xv5oVLH2AiNQ4uh2M7Tw6ejBxoLeLHY0DF-kdzhBNNIHuxtlPK3a0OVKg22lsEhHN5OjU0_3BtEg_gbFH-s1CGGEe0GNIOnAd3bmILpgVk84F9GsSpmSfGJiPr8hVDzbg63O8Id9vP--3d9n91y-77cf7rC1EIbMcuO5Fx3TRKKkYsgZyLZpC9ZXMsVeaFR2iFFD1rGkFw7YtO9ZoIbEXeafEDXl3mpse8mvBEOvRhBatBYfTEuqyynVVlnkC9Qls_RSCx76evRnBH2vO6j9O1P-cqC9OnEpJ-uZ8x9KM2F2E59Wn_ttzH0ILtvfgWhMumNJFmscSVpyww2Qj-vDTLgf09YBg41D_7x-IJ2zdooo</recordid><startdate>198908</startdate><enddate>198908</enddate><creator>Shin, Kenji</creator><creator>Nagai, Yoji</creator><creator>Hirano, Chiaki</creator><creator>Kataoka, Natsue</creator><creator>Ono, Ichiro</creator><creator>Yamamura, Eiji</creator><creator>Moriyama, Chiaki</creator><creator>Horigome, Yumi</creator><creator>Ehara, Takao</creator><creator>Kamoda, Tomohiro</creator><creator>Sumazaki, Ryo</creator><creator>Hanada, Takashi</creator><creator>Hamano, Kenzo</creator><creator>Ogata, Takesaburo</creator><creator>Takita, Hitoshi</creator><general>Lippincott-Raven Publishers</general><general>Lippincott</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>198908</creationdate><title>Survival Rate in Children with Fulminant Hepatitis Improved by a Combination of Twice Daily Plasmapheresis and Intensive Conservative Therapy</title><author>Shin, Kenji ; Nagai, Yoji ; Hirano, Chiaki ; Kataoka, Natsue ; Ono, Ichiro ; Yamamura, Eiji ; Moriyama, Chiaki ; Horigome, Yumi ; Ehara, Takao ; Kamoda, Tomohiro ; Sumazaki, Ryo ; Hanada, Takashi ; Hamano, Kenzo ; Ogata, Takesaburo ; Takita, Hitoshi</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4345-2a18f3d084b6560e0ba283b46f952ef6804dee53a9f0bc30ecc7d0b835ef32d63</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1989</creationdate><topic>Acute Disease</topic><topic>Biological and medical sciences</topic><topic>Child</topic><topic>Child, Preschool</topic><topic>Combined Modality Therapy</topic><topic>Evaluation Studies as Topic</topic><topic>Female</topic><topic>Hepatic Encephalopathy - mortality</topic><topic>Hepatic Encephalopathy - therapy</topic><topic>Hepatitis - mortality</topic><topic>Hepatitis - therapy</topic><topic>Human viral diseases</topic><topic>Humans</topic><topic>Infant</topic><topic>Infectious diseases</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Parenteral Nutrition</topic><topic>Plasmapheresis - methods</topic><topic>Survival Rate</topic><topic>Viral diseases</topic><topic>Viral hepatitis</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Shin, Kenji</creatorcontrib><creatorcontrib>Nagai, Yoji</creatorcontrib><creatorcontrib>Hirano, Chiaki</creatorcontrib><creatorcontrib>Kataoka, Natsue</creatorcontrib><creatorcontrib>Ono, Ichiro</creatorcontrib><creatorcontrib>Yamamura, Eiji</creatorcontrib><creatorcontrib>Moriyama, Chiaki</creatorcontrib><creatorcontrib>Horigome, Yumi</creatorcontrib><creatorcontrib>Ehara, Takao</creatorcontrib><creatorcontrib>Kamoda, Tomohiro</creatorcontrib><creatorcontrib>Sumazaki, Ryo</creatorcontrib><creatorcontrib>Hanada, Takashi</creatorcontrib><creatorcontrib>Hamano, Kenzo</creatorcontrib><creatorcontrib>Ogata, Takesaburo</creatorcontrib><creatorcontrib>Takita, Hitoshi</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of pediatric gastroenterology and nutrition</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Shin, Kenji</au><au>Nagai, Yoji</au><au>Hirano, Chiaki</au><au>Kataoka, Natsue</au><au>Ono, Ichiro</au><au>Yamamura, Eiji</au><au>Moriyama, Chiaki</au><au>Horigome, Yumi</au><au>Ehara, Takao</au><au>Kamoda, Tomohiro</au><au>Sumazaki, Ryo</au><au>Hanada, Takashi</au><au>Hamano, Kenzo</au><au>Ogata, Takesaburo</au><au>Takita, Hitoshi</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Survival Rate in Children with Fulminant Hepatitis Improved by a Combination of Twice Daily Plasmapheresis and Intensive Conservative Therapy</atitle><jtitle>Journal of pediatric gastroenterology and nutrition</jtitle><addtitle>J Pediatr Gastroenterol Nutr</addtitle><date>1989-08</date><risdate>1989</risdate><volume>9</volume><issue>2</issue><spage>163</spage><epage>166</epage><pages>163-166</pages><issn>0277-2116</issn><eissn>1536-4801</eissn><coden>JPGND6</coden><abstract>Six of seven children with fulminant hepatitis (FH) were treated with a combination of twice daily plasmapheresis and intensive conservative therapy including special amino acid solution, glucagon-insulin therapy, dexamethasone, and so on. The remaining child was treated with intensive conservative therapy only because his condition was not so severe, in spite of being diagnosed as having fulminant hepatitis. Although five patients with biopsy-documented bridging hepatic necrosis or confluent hepatic necrosis in the acute phase made recoveries, the remaining two with massive hepatic necrosis died (the overall survival rate was 71%). The prognostic factors were considered to be the degree and pattern of liver cell necrosis, the degree of coma, and the etiology. The combination of twice daily plasmapheresis and intensive conservative therapy was effective for these pediatric patients with fulminant hepatitis, except those with massive hepatic necrosis.</abstract><cop>Hagerstown, MD</cop><pub>Lippincott-Raven Publishers</pub><pmid>2509666</pmid><doi>10.1097/00005176-198908000-00005</doi><tpages>4</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0277-2116 |
| ispartof | Journal of pediatric gastroenterology and nutrition, 1989-08, Vol.9 (2), p.163-166 |
| issn | 0277-2116 1536-4801 |
| language | eng |
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| source | MEDLINE; Journals@Ovid Complete |
| subjects | Acute Disease Biological and medical sciences Child Child, Preschool Combined Modality Therapy Evaluation Studies as Topic Female Hepatic Encephalopathy - mortality Hepatic Encephalopathy - therapy Hepatitis - mortality Hepatitis - therapy Human viral diseases Humans Infant Infectious diseases Male Medical sciences Parenteral Nutrition Plasmapheresis - methods Survival Rate Viral diseases Viral hepatitis |
| title | Survival Rate in Children with Fulminant Hepatitis Improved by a Combination of Twice Daily Plasmapheresis and Intensive Conservative Therapy |
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