Moderate doses of iodide in vivo inhibit cell proliferation and the expression of thyroperoxidase and Na +/I − symporter mRNAs in dog thyroid

The function and the growth of adult thyroid gland is controlled by the opposite actions of thyrotropin (TSH) and iodide, the main substrate of the gland. Iodide deprivation leads to stimulation of the thyroid, improving the efficiency of iodide transport for hormone biosynthesis. We have investigat...

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Veröffentlicht in:	Molecular and cellular endocrinology 1997-08, Vol.131 (2), p.195-203
Hauptverfasser:	Uyttersprot, N, Pelgrims, N, Carrasco, N, Gervy, C, Maenhaut, C, Dumont, J.E, Miot, F
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Blotting, Northern Carrier Proteins - genetics Cell Division - drug effects Dog thyroid gene expression Dogs Gene Expression - drug effects Hypothyroidism - metabolism Iodide Iodide Peroxidase - genetics Membrane Proteins - genetics Perchlorates - pharmacology Potassium Iodide - pharmacology Proliferation Propylthiouracil - pharmacology Receptors, Thyrotropin - genetics RNA, Messenger - metabolism Sodium Compounds - pharmacology Symporters Thyroglobulin - genetics Thyroid Gland - cytology Thyroid Gland - drug effects Thyroid Gland - metabolism Thyrotropin - blood Thyroxine - blood Triiodothyronine - blood
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