Chronic actinic dermatitis: An immunohistologic and photobiologic study
Photobiologic, histologic, and immunohistochemical findings in 14 patients with chronic actinic dermatitis were compared. Grading of routine histologic features of involved skin demonstrated a spectrum of abnormalities ranging from changes resembling chronic dermatitis to those of cutaneous T cell l...
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| Veröffentlicht in: | Journal of the American Academy of Dermatology 1989-11, Vol.21 (5), p.966-971 |
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| container_title | Journal of the American Academy of Dermatology |
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| creator | Norris, Paul G. Morris, Jenny Smith, Neil P. Chu, Anthony C. Hawk, John L.M. |
| description | Photobiologic, histologic, and immunohistochemical findings in 14 patients with chronic actinic dermatitis were compared. Grading of routine histologic features of involved skin demonstrated a spectrum of abnormalities ranging from changes resembling chronic dermatitis to those of cutaneous T cell lymphoma. Immunohistochemical staining showed dermal infiltrates to consist predominantly of T lymphocytes, with a significant trend toward lower CD4
+/CD8
+ ratios in cases with more florid histologic findings. Circulating CD4
+/CD8
+ cell ratios were normal in five patients and reduced in one patient. Photosensitivity extending to wavelengths longer than 340 nm was detected in eight patients, but the spectrum of photobiologic abnormality did not appear to correlate with either grading of histologic severity or variation in T cell subsets in lesional skin. |
| doi_str_mv | 10.1016/S0190-9622(89)70284-X |
| format | Article |
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+/CD8
+ ratios in cases with more florid histologic findings. Circulating CD4
+/CD8
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+/CD8
+ ratios in cases with more florid histologic findings. Circulating CD4
+/CD8
+ cell ratios were normal in five patients and reduced in one patient. Photosensitivity extending to wavelengths longer than 340 nm was detected in eight patients, but the spectrum of photobiologic abnormality did not appear to correlate with either grading of histologic severity or variation in T cell subsets in lesional skin.</description><subject>Aged</subject><subject>Biological and medical sciences</subject><subject>Cell Count</subject><subject>Chronic Disease</subject><subject>Eczema - immunology</subject><subject>Eczema - pathology</subject><subject>Humans</subject><subject>Injuries of the skin. Diseases of the skin due to physical agents</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Patch Tests</subject><subject>Photosensitivity Disorders - immunology</subject><subject>Photosensitivity Disorders - pathology</subject><subject>T-Lymphocytes - immunology</subject><subject>T-Lymphocytes - pathology</subject><subject>Traumas. 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Diseases of the skin due to physical agents</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Patch Tests</topic><topic>Photosensitivity Disorders - immunology</topic><topic>Photosensitivity Disorders - pathology</topic><topic>T-Lymphocytes - immunology</topic><topic>T-Lymphocytes - pathology</topic><topic>Traumas. Diseases due to physical agents</topic><topic>Ultraviolet Rays</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Norris, Paul G.</creatorcontrib><creatorcontrib>Morris, Jenny</creatorcontrib><creatorcontrib>Smith, Neil P.</creatorcontrib><creatorcontrib>Chu, Anthony C.</creatorcontrib><creatorcontrib>Hawk, John L.M.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of the American Academy of Dermatology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Norris, Paul G.</au><au>Morris, Jenny</au><au>Smith, Neil P.</au><au>Chu, Anthony C.</au><au>Hawk, John L.M.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Chronic actinic dermatitis: An immunohistologic and photobiologic study</atitle><jtitle>Journal of the American Academy of Dermatology</jtitle><addtitle>J Am Acad Dermatol</addtitle><date>1989-11-01</date><risdate>1989</risdate><volume>21</volume><issue>5</issue><spage>966</spage><epage>971</epage><pages>966-971</pages><issn>0190-9622</issn><eissn>1097-6787</eissn><coden>JAADDB</coden><abstract>Photobiologic, histologic, and immunohistochemical findings in 14 patients with chronic actinic dermatitis were compared. Grading of routine histologic features of involved skin demonstrated a spectrum of abnormalities ranging from changes resembling chronic dermatitis to those of cutaneous T cell lymphoma. Immunohistochemical staining showed dermal infiltrates to consist predominantly of T lymphocytes, with a significant trend toward lower CD4
+/CD8
+ ratios in cases with more florid histologic findings. Circulating CD4
+/CD8
+ cell ratios were normal in five patients and reduced in one patient. Photosensitivity extending to wavelengths longer than 340 nm was detected in eight patients, but the spectrum of photobiologic abnormality did not appear to correlate with either grading of histologic severity or variation in T cell subsets in lesional skin.</abstract><cop>New York, NY</cop><pub>Mosby, Inc</pub><pmid>2808833</pmid><doi>10.1016/S0190-9622(89)70284-X</doi><tpages>6</tpages></addata></record> |
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| identifier | ISSN: 0190-9622 |
| ispartof | Journal of the American Academy of Dermatology, 1989-11, Vol.21 (5), p.966-971 |
| issn | 0190-9622 1097-6787 |
| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Aged Biological and medical sciences Cell Count Chronic Disease Eczema - immunology Eczema - pathology Humans Injuries of the skin. Diseases of the skin due to physical agents Male Medical sciences Middle Aged Patch Tests Photosensitivity Disorders - immunology Photosensitivity Disorders - pathology T-Lymphocytes - immunology T-Lymphocytes - pathology Traumas. Diseases due to physical agents Ultraviolet Rays |
| title | Chronic actinic dermatitis: An immunohistologic and photobiologic study |
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