In Vitro NMR Evaluation of Human Thyroid Lesions
In vitro analysis of spin-lattice relaxation times (Tl), water self-diffusion coefficients (D) and proton NMR spectroscopy were performed in a study of 88 patients with thyroid lesions in order to determine the usefulness of these parameters in the differentiation of benign and malignant tissues. Th...
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| Veröffentlicht in: | Investigative radiology 1989-09, Vol.24 (9), p.666-671 |
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| container_title | Investigative radiology |
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| creator | JOHNSON, MICHAEL SELINSKY, BARRY DAVIS, MARJORIE LAWRENCE, TOMMY L CLEVELAND, GREG PERRY, J RANDOLPH THOMAS, COLIN G KWOCK, LESTER |
| description | In vitro analysis of spin-lattice relaxation times (Tl), water self-diffusion coefficients (D) and proton NMR spectroscopy were performed in a study of 88 patients with thyroid lesions in order to determine the usefulness of these parameters in the differentiation of benign and malignant tissues. Thyroid tissue sample proton NMR spectral patterns were examined at 360 MHz. Proton NMR spectra were different for normal thyroid tissues, benign, and cancerous lesions. Significantly prolonged Tl (0.5T) and decreased D were found in cancerous thyroid lesions relative to normal thyroid tissues. Considerable overlap was found, however, in comparing Tl and D values for benign and malignant thyroid lesions. This study suggests that proton NMR spectroscopy may be more useful than Tl and D in differentiating benign and malignant thyroid lesions. |
| doi_str_mv | 10.1097/00004424-198909000-00004 |
| format | Article |
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Thyroid tissue sample proton NMR spectral patterns were examined at 360 MHz. Proton NMR spectra were different for normal thyroid tissues, benign, and cancerous lesions. Significantly prolonged Tl (0.5T) and decreased D were found in cancerous thyroid lesions relative to normal thyroid tissues. Considerable overlap was found, however, in comparing Tl and D values for benign and malignant thyroid lesions. 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Thyroid tissue sample proton NMR spectral patterns were examined at 360 MHz. Proton NMR spectra were different for normal thyroid tissues, benign, and cancerous lesions. Significantly prolonged Tl (0.5T) and decreased D were found in cancerous thyroid lesions relative to normal thyroid tissues. Considerable overlap was found, however, in comparing Tl and D values for benign and malignant thyroid lesions. This study suggests that proton NMR spectroscopy may be more useful than Tl and D in differentiating benign and malignant thyroid lesions.</description><subject>Adenoma - analysis</subject><subject>Adenoma - diagnosis</subject><subject>Carcinoma - analysis</subject><subject>Carcinoma - diagnosis</subject><subject>Diagnosis, Differential</subject><subject>Humans</subject><subject>In Vitro Techniques</subject><subject>Magnetic Resonance Spectroscopy</subject><subject>Reference Values</subject><subject>Thyroid Diseases - diagnosis</subject><subject>Thyroid Gland - analysis</subject><subject>Thyroid Neoplasms - analysis</subject><subject>Thyroid Neoplasms - diagnosis</subject><issn>0020-9996</issn><issn>1536-0210</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1989</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1UctOwzAQtBColMInIPnELbB-xImPqCptpQISKlwtJ3HUQBIXO6Hq32NI6Y29rHZ2ZkeaRQgTuCUgkzsIxTnlEZGpBBmm6Bc6QWMSMxEBJXCKxgAUIimlOEcX3r8HBk2AjdCIppCkRI4RLFv8VnXO4qfHFzz70nWvu8q22JZ40Te6xevN3tmqwCvjA-4v0Vmpa2-uDn2CXh9m6-kiWj3Pl9P7VZQHCx7FQkOclQVQk3BW8GCYsSJOcgFaSAGCEgEy4yUjmmgTp1RnpYwFT3Oi80ywCboZ7m6d_eyN71RT-dzUtW6N7b1KJE0TIVggpgMxd9Z7Z0q1dVWj3V4RUD9hqb-w1DGsAQrS64NHnzWmOAoP6YQ9H_Y7W3fG-Y-63xmnNkbX3Ub99wP2DcqScYo</recordid><startdate>198909</startdate><enddate>198909</enddate><creator>JOHNSON, MICHAEL</creator><creator>SELINSKY, BARRY</creator><creator>DAVIS, MARJORIE</creator><creator>LAWRENCE, TOMMY L</creator><creator>CLEVELAND, GREG</creator><creator>PERRY, J RANDOLPH</creator><creator>THOMAS, COLIN G</creator><creator>KWOCK, LESTER</creator><general>Lippincott-Raven Publishers</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>198909</creationdate><title>In Vitro NMR Evaluation of Human Thyroid Lesions</title><author>JOHNSON, MICHAEL ; SELINSKY, BARRY ; DAVIS, MARJORIE ; LAWRENCE, TOMMY L ; CLEVELAND, GREG ; PERRY, J RANDOLPH ; THOMAS, COLIN G ; KWOCK, LESTER</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c2704-56a05bfd02e743d4280b3d57c60a6960621609b4f31a1ae582abf95648c1acb63</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1989</creationdate><topic>Adenoma - analysis</topic><topic>Adenoma - diagnosis</topic><topic>Carcinoma - analysis</topic><topic>Carcinoma - diagnosis</topic><topic>Diagnosis, Differential</topic><topic>Humans</topic><topic>In Vitro Techniques</topic><topic>Magnetic Resonance Spectroscopy</topic><topic>Reference Values</topic><topic>Thyroid Diseases - diagnosis</topic><topic>Thyroid Gland - analysis</topic><topic>Thyroid Neoplasms - analysis</topic><topic>Thyroid Neoplasms - diagnosis</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>JOHNSON, MICHAEL</creatorcontrib><creatorcontrib>SELINSKY, BARRY</creatorcontrib><creatorcontrib>DAVIS, MARJORIE</creatorcontrib><creatorcontrib>LAWRENCE, TOMMY L</creatorcontrib><creatorcontrib>CLEVELAND, GREG</creatorcontrib><creatorcontrib>PERRY, J RANDOLPH</creatorcontrib><creatorcontrib>THOMAS, COLIN G</creatorcontrib><creatorcontrib>KWOCK, LESTER</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Investigative radiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>JOHNSON, MICHAEL</au><au>SELINSKY, BARRY</au><au>DAVIS, MARJORIE</au><au>LAWRENCE, TOMMY L</au><au>CLEVELAND, GREG</au><au>PERRY, J RANDOLPH</au><au>THOMAS, COLIN G</au><au>KWOCK, LESTER</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>In Vitro NMR Evaluation of Human Thyroid Lesions</atitle><jtitle>Investigative radiology</jtitle><addtitle>Invest Radiol</addtitle><date>1989-09</date><risdate>1989</risdate><volume>24</volume><issue>9</issue><spage>666</spage><epage>671</epage><pages>666-671</pages><issn>0020-9996</issn><eissn>1536-0210</eissn><abstract>In vitro analysis of spin-lattice relaxation times (Tl), water self-diffusion coefficients (D) and proton NMR spectroscopy were performed in a study of 88 patients with thyroid lesions in order to determine the usefulness of these parameters in the differentiation of benign and malignant tissues. Thyroid tissue sample proton NMR spectral patterns were examined at 360 MHz. Proton NMR spectra were different for normal thyroid tissues, benign, and cancerous lesions. Significantly prolonged Tl (0.5T) and decreased D were found in cancerous thyroid lesions relative to normal thyroid tissues. Considerable overlap was found, however, in comparing Tl and D values for benign and malignant thyroid lesions. This study suggests that proton NMR spectroscopy may be more useful than Tl and D in differentiating benign and malignant thyroid lesions.</abstract><cop>United States</cop><pub>Lippincott-Raven Publishers</pub><pmid>2807819</pmid><doi>10.1097/00004424-198909000-00004</doi><tpages>6</tpages></addata></record> |
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| ispartof | Investigative radiology, 1989-09, Vol.24 (9), p.666-671 |
| issn | 0020-9996 1536-0210 |
| language | eng |
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| source | MEDLINE; Journals@Ovid Complete |
| subjects | Adenoma - analysis Adenoma - diagnosis Carcinoma - analysis Carcinoma - diagnosis Diagnosis, Differential Humans In Vitro Techniques Magnetic Resonance Spectroscopy Reference Values Thyroid Diseases - diagnosis Thyroid Gland - analysis Thyroid Neoplasms - analysis Thyroid Neoplasms - diagnosis |
| title | In Vitro NMR Evaluation of Human Thyroid Lesions |
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