Human brain and spinal cord scan after intracerebroventricular administration of iodine-123 morphine
[ 123I]iodomorphine (IMPH) was administered intracerebroventriculary (i.c.v.) in eight patients treated by i.c.v. morphinotherapy (i.c.v.m.). Scans obtained by γ-scintigraphy over 1 h post-injection showed only a slight diffusion of IMPH beyond the ventricular system, particular attention being paid...
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| Veröffentlicht in: | International journal of radiation applications and instrumentation. Part B, Nuclear medicine and biology Nuclear medicine and biology, 1989, Vol.16 (5), p.505-509 |
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| container_issue | 5 |
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| container_title | International journal of radiation applications and instrumentation. Part B, Nuclear medicine and biology |
| container_volume | 16 |
| creator | Tafani, J.A.M. Lazorthes, Y. Danet, B. Verdie, J.C. Esquerre, J.P. Simon, J. Guiraud, R. |
| description | [
123I]iodomorphine (IMPH) was administered intracerebroventriculary (i.c.v.) in eight patients treated by i.c.v. morphinotherapy (i.c.v.m.). Scans obtained by γ-scintigraphy over 1 h post-injection showed only a slight diffusion of IMPH beyond the ventricular system, particular attention being paid to the spinal cord.
These data agree well with induced i.c.v.m. analgesia (mean latency 20 min) and biological results such as HPLC assay of morphine in the lumbar cerebrospinal fluid, supporting the action of morphine only on the central opiate receptors. |
| doi_str_mv | 10.1016/0883-2897(89)90064-0 |
| format | Article |
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123I]iodomorphine (IMPH) was administered intracerebroventriculary (i.c.v.) in eight patients treated by i.c.v. morphinotherapy (i.c.v.m.). Scans obtained by γ-scintigraphy over 1 h post-injection showed only a slight diffusion of IMPH beyond the ventricular system, particular attention being paid to the spinal cord.
These data agree well with induced i.c.v.m. analgesia (mean latency 20 min) and biological results such as HPLC assay of morphine in the lumbar cerebrospinal fluid, supporting the action of morphine only on the central opiate receptors.</description><identifier>ISSN: 0883-2897</identifier><identifier>DOI: 10.1016/0883-2897(89)90064-0</identifier><identifier>PMID: 2807956</identifier><language>eng</language><publisher>England: Elsevier Ltd</publisher><subject>Brain - diagnostic imaging ; Humans ; Injections, Intraventricular ; Iodine Radioisotopes ; Morphine Derivatives - administration & dosage ; Morphine Derivatives - metabolism ; Morphine Derivatives - therapeutic use ; Pain, Intractable - drug therapy ; Radionuclide Imaging ; Spinal Cord - diagnostic imaging</subject><ispartof>International journal of radiation applications and instrumentation. Part B, Nuclear medicine and biology, 1989, Vol.16 (5), p.505-509</ispartof><rights>1989</rights><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c342t-3bfc0d307316b4eddc7e054afb5267ce9fd4ed07819b1b7b521e9fa31e8687273</citedby><cites>FETCH-LOGICAL-c342t-3bfc0d307316b4eddc7e054afb5267ce9fd4ed07819b1b7b521e9fa31e8687273</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,4010,27900,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/2807956$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Tafani, J.A.M.</creatorcontrib><creatorcontrib>Lazorthes, Y.</creatorcontrib><creatorcontrib>Danet, B.</creatorcontrib><creatorcontrib>Verdie, J.C.</creatorcontrib><creatorcontrib>Esquerre, J.P.</creatorcontrib><creatorcontrib>Simon, J.</creatorcontrib><creatorcontrib>Guiraud, R.</creatorcontrib><title>Human brain and spinal cord scan after intracerebroventricular administration of iodine-123 morphine</title><title>International journal of radiation applications and instrumentation. Part B, Nuclear medicine and biology</title><addtitle>Int J Rad Appl Instrum B</addtitle><description>[
123I]iodomorphine (IMPH) was administered intracerebroventriculary (i.c.v.) in eight patients treated by i.c.v. morphinotherapy (i.c.v.m.). Scans obtained by γ-scintigraphy over 1 h post-injection showed only a slight diffusion of IMPH beyond the ventricular system, particular attention being paid to the spinal cord.
These data agree well with induced i.c.v.m. analgesia (mean latency 20 min) and biological results such as HPLC assay of morphine in the lumbar cerebrospinal fluid, supporting the action of morphine only on the central opiate receptors.</description><subject>Brain - diagnostic imaging</subject><subject>Humans</subject><subject>Injections, Intraventricular</subject><subject>Iodine Radioisotopes</subject><subject>Morphine Derivatives - administration & dosage</subject><subject>Morphine Derivatives - metabolism</subject><subject>Morphine Derivatives - therapeutic use</subject><subject>Pain, Intractable - drug therapy</subject><subject>Radionuclide Imaging</subject><subject>Spinal Cord - diagnostic imaging</subject><issn>0883-2897</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1989</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kD1PwzAQhj2ASin8A5A8IRgC_khiZ0FCFVCkSiwwW459EUaJXeykEv8el1aMTHf3vvehexC6oOSWElrfESl5wWQjrmVz0xBSlwU5QvM_-QSdpvRJCJNlJWZoxiQRTVXPkV1Ng_a4jdp5rL3FaeO87rEJMecmW7obIWLnx6gNRGhj2EIunJl6HbG2g_MuZXN0wePQYRes81BQxvEQ4uYjF2fouNN9gvNDXKD3p8e35apYvz6_LB_WheElGwvedoZYTgSndVuCtUYAqUrdtRWrhYGms1klQtKmpa3IKs2a5hRkLQUTfIGu9ns3MXxNkEY1uGSg77WHMCUlGiZrTqrcWO4bTQwpRejUJrpBx29FidoBVTtyakdOyUb9AlUkj10e9k_tAPZv6EAz-_d7H_KTWwdRJePAG7AughmVDe7_Az8RJoiQ</recordid><startdate>1989</startdate><enddate>1989</enddate><creator>Tafani, J.A.M.</creator><creator>Lazorthes, Y.</creator><creator>Danet, B.</creator><creator>Verdie, J.C.</creator><creator>Esquerre, J.P.</creator><creator>Simon, J.</creator><creator>Guiraud, R.</creator><general>Elsevier Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>1989</creationdate><title>Human brain and spinal cord scan after intracerebroventricular administration of iodine-123 morphine</title><author>Tafani, J.A.M. ; Lazorthes, Y. ; Danet, B. ; Verdie, J.C. ; Esquerre, J.P. ; Simon, J. ; Guiraud, R.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c342t-3bfc0d307316b4eddc7e054afb5267ce9fd4ed07819b1b7b521e9fa31e8687273</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1989</creationdate><topic>Brain - diagnostic imaging</topic><topic>Humans</topic><topic>Injections, Intraventricular</topic><topic>Iodine Radioisotopes</topic><topic>Morphine Derivatives - administration & dosage</topic><topic>Morphine Derivatives - metabolism</topic><topic>Morphine Derivatives - therapeutic use</topic><topic>Pain, Intractable - drug therapy</topic><topic>Radionuclide Imaging</topic><topic>Spinal Cord - diagnostic imaging</topic><toplevel>online_resources</toplevel><creatorcontrib>Tafani, J.A.M.</creatorcontrib><creatorcontrib>Lazorthes, Y.</creatorcontrib><creatorcontrib>Danet, B.</creatorcontrib><creatorcontrib>Verdie, J.C.</creatorcontrib><creatorcontrib>Esquerre, J.P.</creatorcontrib><creatorcontrib>Simon, J.</creatorcontrib><creatorcontrib>Guiraud, R.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>International journal of radiation applications and instrumentation. Part B, Nuclear medicine and biology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Tafani, J.A.M.</au><au>Lazorthes, Y.</au><au>Danet, B.</au><au>Verdie, J.C.</au><au>Esquerre, J.P.</au><au>Simon, J.</au><au>Guiraud, R.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Human brain and spinal cord scan after intracerebroventricular administration of iodine-123 morphine</atitle><jtitle>International journal of radiation applications and instrumentation. Part B, Nuclear medicine and biology</jtitle><addtitle>Int J Rad Appl Instrum B</addtitle><date>1989</date><risdate>1989</risdate><volume>16</volume><issue>5</issue><spage>505</spage><epage>509</epage><pages>505-509</pages><issn>0883-2897</issn><abstract>[
123I]iodomorphine (IMPH) was administered intracerebroventriculary (i.c.v.) in eight patients treated by i.c.v. morphinotherapy (i.c.v.m.). Scans obtained by γ-scintigraphy over 1 h post-injection showed only a slight diffusion of IMPH beyond the ventricular system, particular attention being paid to the spinal cord.
These data agree well with induced i.c.v.m. analgesia (mean latency 20 min) and biological results such as HPLC assay of morphine in the lumbar cerebrospinal fluid, supporting the action of morphine only on the central opiate receptors.</abstract><cop>England</cop><pub>Elsevier Ltd</pub><pmid>2807956</pmid><doi>10.1016/0883-2897(89)90064-0</doi><tpages>5</tpages></addata></record> |
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| identifier | ISSN: 0883-2897 |
| ispartof | International journal of radiation applications and instrumentation. Part B, Nuclear medicine and biology, 1989, Vol.16 (5), p.505-509 |
| issn | 0883-2897 |
| language | eng |
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| source | MEDLINE; Alma/SFX Local Collection |
| subjects | Brain - diagnostic imaging Humans Injections, Intraventricular Iodine Radioisotopes Morphine Derivatives - administration & dosage Morphine Derivatives - metabolism Morphine Derivatives - therapeutic use Pain, Intractable - drug therapy Radionuclide Imaging Spinal Cord - diagnostic imaging |
| title | Human brain and spinal cord scan after intracerebroventricular administration of iodine-123 morphine |
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