Non-correlation between Debrisoquine and Metoprolol Polymorphisms in the Venda
1 The metabolic 4-hydroxylation of debrisoquine has been studied in a group of 98 black African villagers in Vendaland. 2 The metabolic α-hydroxylation of metoprolol has been studied in 94 of the same black African villagers. 3 A 4% prevalence of poor oxidative metabolism of debrisoquine and a 7.4%...
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| Veröffentlicht in: | Human & experimental toxicology 1989-09, Vol.8 (5), p.365-368 |
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| creator | Sommers, De K. Moncrieff, J. Avenant, J. |
| description | 1 The metabolic 4-hydroxylation of debrisoquine has been studied in a group of 98 black African villagers in Vendaland.
2 The metabolic α-hydroxylation of metoprolol has been studied in 94 of the same black African villagers.
3 A 4% prevalence of poor oxidative metabolism of debrisoquine and a 7.4% incidence of poor oxidation of metoprolol were found. The 4% result for debrisoquine differs considerably from the 19% found in San Bushmen, 30% in Hong Kong Chinese, 9% in Britains and 0% in Nigerians and Japanese, whilst the 7.4% result for metoprolol compares with 8.4% in Britains but differs from 0% in Nigerians and 4.1% in San Bushmen.
4 None of the poor oxidative metabolizers of debrisoquine were also poor oxidative metabolizers of metoprolol. This is contrary to results in British and Nigerian subjects where defective oxidation of metoprolol co-segrates with that of debrisoquine.
5 No similarities were found between the Venda metabolic ratio (MR) distributions and either extensive or poor MR distributions in Britains or Nigerians. |
| doi_str_mv | 10.1177/096032718900800506 |
| format | Article |
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2 The metabolic α-hydroxylation of metoprolol has been studied in 94 of the same black African villagers.
3 A 4% prevalence of poor oxidative metabolism of debrisoquine and a 7.4% incidence of poor oxidation of metoprolol were found. The 4% result for debrisoquine differs considerably from the 19% found in San Bushmen, 30% in Hong Kong Chinese, 9% in Britains and 0% in Nigerians and Japanese, whilst the 7.4% result for metoprolol compares with 8.4% in Britains but differs from 0% in Nigerians and 4.1% in San Bushmen.
4 None of the poor oxidative metabolizers of debrisoquine were also poor oxidative metabolizers of metoprolol. This is contrary to results in British and Nigerian subjects where defective oxidation of metoprolol co-segrates with that of debrisoquine.
5 No similarities were found between the Venda metabolic ratio (MR) distributions and either extensive or poor MR distributions in Britains or Nigerians.</description><identifier>ISSN: 0144-5952</identifier><identifier>ISSN: 0960-3271</identifier><identifier>DOI: 10.1177/096032718900800506</identifier><identifier>PMID: 2807305</identifier><identifier>CODEN: HUTODJ</identifier><language>eng</language><publisher>Thousand Oaks, CA: SAGE Publications</publisher><subject>African Continental Ancestry Group ; Biological and medical sciences ; Chromatography, High Pressure Liquid ; Debrisoquin - metabolism ; Female ; General pharmacology ; Humans ; Hydroxylation ; Isoquinolines - metabolism ; Male ; Medical sciences ; Metoprolol - metabolism ; Pharmacokinetics. Pharmacogenetics. Drug-receptor interactions ; Pharmacology. Drug treatments ; Phenotype ; South Africa</subject><ispartof>Human & experimental toxicology, 1989-09, Vol.8 (5), p.365-368</ispartof><rights>1990 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c534t-6ac8a88817c79a183b75c8b7a3b40853d07105b3b49c653decc7a8ba1e5585123</citedby><cites>FETCH-LOGICAL-c534t-6ac8a88817c79a183b75c8b7a3b40853d07105b3b49c653decc7a8ba1e5585123</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://journals.sagepub.com/doi/pdf/10.1177/096032718900800506$$EPDF$$P50$$Gsage$$H</linktopdf><linktohtml>$$Uhttps://journals.sagepub.com/doi/10.1177/096032718900800506$$EHTML$$P50$$Gsage$$H</linktohtml><link.rule.ids>314,780,784,21819,27924,27925,43621,43622</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=6784121$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/2807305$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Sommers, De K.</creatorcontrib><creatorcontrib>Moncrieff, J.</creatorcontrib><creatorcontrib>Avenant, J.</creatorcontrib><title>Non-correlation between Debrisoquine and Metoprolol Polymorphisms in the Venda</title><title>Human & experimental toxicology</title><addtitle>Hum Toxicol</addtitle><description>1 The metabolic 4-hydroxylation of debrisoquine has been studied in a group of 98 black African villagers in Vendaland.
2 The metabolic α-hydroxylation of metoprolol has been studied in 94 of the same black African villagers.
3 A 4% prevalence of poor oxidative metabolism of debrisoquine and a 7.4% incidence of poor oxidation of metoprolol were found. The 4% result for debrisoquine differs considerably from the 19% found in San Bushmen, 30% in Hong Kong Chinese, 9% in Britains and 0% in Nigerians and Japanese, whilst the 7.4% result for metoprolol compares with 8.4% in Britains but differs from 0% in Nigerians and 4.1% in San Bushmen.
4 None of the poor oxidative metabolizers of debrisoquine were also poor oxidative metabolizers of metoprolol. This is contrary to results in British and Nigerian subjects where defective oxidation of metoprolol co-segrates with that of debrisoquine.
5 No similarities were found between the Venda metabolic ratio (MR) distributions and either extensive or poor MR distributions in Britains or Nigerians.</description><subject>African Continental Ancestry Group</subject><subject>Biological and medical sciences</subject><subject>Chromatography, High Pressure Liquid</subject><subject>Debrisoquin - metabolism</subject><subject>Female</subject><subject>General pharmacology</subject><subject>Humans</subject><subject>Hydroxylation</subject><subject>Isoquinolines - metabolism</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Metoprolol - metabolism</subject><subject>Pharmacokinetics. Pharmacogenetics. Drug-receptor interactions</subject><subject>Pharmacology. Drug treatments</subject><subject>Phenotype</subject><subject>South Africa</subject><issn>0144-5952</issn><issn>0960-3271</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1989</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkM1OwzAQhH0AlVJ4ASSkHBC30LUdx84RlV-pFA7ANXLcLU2V2K2dCPXtMWrFBQlOq9F-M7saQs4oXFEq5RiKHDiTVBUACkBAfkCGQLMsFYVgR-Q4hBUAj2g2IAOmQHIQQzKbOZsa5z02uqudTSrsPhFtcoOVr4Pb9LXFRNt58oSdW3vXuCZ5cc22dX69rEMbktom3RKTd7RzfUIOF7oJeLqfI_J2d_s6eUinz_ePk-tpagTPujTXRmmlFJVGFpoqXklhVCU1rzJQgs9BUhBVVIXJo0RjpFaVpiiEEpTxEbnc5caPNj2GrmzrYLBptEXXh1IWTPGiEP-CjIJkmYQIsh1ovAvB46Jc-7rVfltSKL8bLn83HE3n-_S-anH-Y9nXG_cX-70ORjcLr62pww-WS5VRRiM23mFBf2C5cr23sby_Dn8Bv1qRqA</recordid><startdate>19890901</startdate><enddate>19890901</enddate><creator>Sommers, De K.</creator><creator>Moncrieff, J.</creator><creator>Avenant, J.</creator><general>SAGE Publications</general><general>Macmillan</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7U7</scope><scope>C1K</scope><scope>7X8</scope></search><sort><creationdate>19890901</creationdate><title>Non-correlation between Debrisoquine and Metoprolol Polymorphisms in the Venda</title><author>Sommers, De K. ; Moncrieff, J. ; Avenant, J.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c534t-6ac8a88817c79a183b75c8b7a3b40853d07105b3b49c653decc7a8ba1e5585123</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1989</creationdate><topic>African Continental Ancestry Group</topic><topic>Biological and medical sciences</topic><topic>Chromatography, High Pressure Liquid</topic><topic>Debrisoquin - metabolism</topic><topic>Female</topic><topic>General pharmacology</topic><topic>Humans</topic><topic>Hydroxylation</topic><topic>Isoquinolines - metabolism</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Metoprolol - metabolism</topic><topic>Pharmacokinetics. Pharmacogenetics. Drug-receptor interactions</topic><topic>Pharmacology. Drug treatments</topic><topic>Phenotype</topic><topic>South Africa</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Sommers, De K.</creatorcontrib><creatorcontrib>Moncrieff, J.</creatorcontrib><creatorcontrib>Avenant, J.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Toxicology Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><collection>MEDLINE - Academic</collection><jtitle>Human & experimental toxicology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Sommers, De K.</au><au>Moncrieff, J.</au><au>Avenant, J.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Non-correlation between Debrisoquine and Metoprolol Polymorphisms in the Venda</atitle><jtitle>Human & experimental toxicology</jtitle><addtitle>Hum Toxicol</addtitle><date>1989-09-01</date><risdate>1989</risdate><volume>8</volume><issue>5</issue><spage>365</spage><epage>368</epage><pages>365-368</pages><issn>0144-5952</issn><issn>0960-3271</issn><coden>HUTODJ</coden><abstract>1 The metabolic 4-hydroxylation of debrisoquine has been studied in a group of 98 black African villagers in Vendaland.
2 The metabolic α-hydroxylation of metoprolol has been studied in 94 of the same black African villagers.
3 A 4% prevalence of poor oxidative metabolism of debrisoquine and a 7.4% incidence of poor oxidation of metoprolol were found. The 4% result for debrisoquine differs considerably from the 19% found in San Bushmen, 30% in Hong Kong Chinese, 9% in Britains and 0% in Nigerians and Japanese, whilst the 7.4% result for metoprolol compares with 8.4% in Britains but differs from 0% in Nigerians and 4.1% in San Bushmen.
4 None of the poor oxidative metabolizers of debrisoquine were also poor oxidative metabolizers of metoprolol. This is contrary to results in British and Nigerian subjects where defective oxidation of metoprolol co-segrates with that of debrisoquine.
5 No similarities were found between the Venda metabolic ratio (MR) distributions and either extensive or poor MR distributions in Britains or Nigerians.</abstract><cop>Thousand Oaks, CA</cop><pub>SAGE Publications</pub><pmid>2807305</pmid><doi>10.1177/096032718900800506</doi><tpages>4</tpages></addata></record> |
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| ispartof | Human & experimental toxicology, 1989-09, Vol.8 (5), p.365-368 |
| issn | 0144-5952 0960-3271 |
| language | eng |
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| source | Access via SAGE; MEDLINE; Alma/SFX Local Collection |
| subjects | African Continental Ancestry Group Biological and medical sciences Chromatography, High Pressure Liquid Debrisoquin - metabolism Female General pharmacology Humans Hydroxylation Isoquinolines - metabolism Male Medical sciences Metoprolol - metabolism Pharmacokinetics. Pharmacogenetics. Drug-receptor interactions Pharmacology. Drug treatments Phenotype South Africa |
| title | Non-correlation between Debrisoquine and Metoprolol Polymorphisms in the Venda |
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