Transient Analysis of Ocular Drug Delivery: Zero-Volume Effect
Dose volume reduction is one method for reducing the nonproductive loss of ophthalmic drugs caused by premature drainage from the precorneal area. A new mathematical method is presented for calculating the bioavailability enhancement achieved by the dose volume reduction method. This new model sugge...
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| Veröffentlicht in: | Journal of pharmaceutical sciences 1997-09, Vol.86 (9), p.1040-1045 |
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| container_end_page | 1045 |
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| container_issue | 9 |
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| container_title | Journal of pharmaceutical sciences |
| container_volume | 86 |
| creator | Keister, J.C. P.S.Heidmann Missel, P.J. |
| description | Dose volume reduction is one method for reducing the nonproductive loss of ophthalmic drugs caused by premature drainage from the precorneal area. A new mathematical method is presented for calculating the bioavailability enhancement achieved by the dose volume reduction method. This new model suggests that the steady-state assumption used in a previous paper overestimated the bioavailability enhancement, depending upon physical factors such as distribution and diffusion coefficients of the drug in tissue and solution. The analysis shows that transient effects can make a difference up to a complete elimination of the zero-volume effect in those cases where the distribution coefficient is large and the permeability coefficient is small (i.e., for large, lipophilic molecules). |
| doi_str_mv | 10.1021/js960510k |
| format | Article |
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A new mathematical method is presented for calculating the bioavailability enhancement achieved by the dose volume reduction method. This new model suggests that the steady-state assumption used in a previous paper overestimated the bioavailability enhancement, depending upon physical factors such as distribution and diffusion coefficients of the drug in tissue and solution. The analysis shows that transient effects can make a difference up to a complete elimination of the zero-volume effect in those cases where the distribution coefficient is large and the permeability coefficient is small (i.e., for large, lipophilic molecules).</description><identifier>ISSN: 0022-3549</identifier><identifier>EISSN: 1520-6017</identifier><identifier>DOI: 10.1021/js960510k</identifier><identifier>PMID: 9294819</identifier><identifier>CODEN: JPMSAE</identifier><language>eng</language><publisher>New York: Elsevier Inc</publisher><subject>Absorption ; Biological and medical sciences ; Biological Availability ; Cornea - metabolism ; Dosage Forms ; Eye ; Eye - metabolism ; General pharmacology ; Medical sciences ; Models, Biological ; Ophthalmic Solutions - pharmacokinetics ; Pharmacokinetics. Pharmacogenetics. Drug-receptor interactions ; Pharmacology. Drug treatments</subject><ispartof>Journal of pharmaceutical sciences, 1997-09, Vol.86 (9), p.1040-1045</ispartof><rights>1997 Wiley-Liss, Inc. and the American Pharmaceutical Association</rights><rights>Copyright © 1997 Wiley‐Liss, Inc. and the American Pharmaceutical Association</rights><rights>1997 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4282-4565a3516ff5e5d5dacbd20773432b6bed29971c5a0f926354732147ed0925c63</citedby><cites>FETCH-LOGICAL-c4282-4565a3516ff5e5d5dacbd20773432b6bed29971c5a0f926354732147ed0925c63</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1021%2Fjs960510k$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1021%2Fjs960510k$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27903,27904,45553,45554</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=2811676$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/9294819$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Keister, J.C.</creatorcontrib><creatorcontrib>P.S.Heidmann</creatorcontrib><creatorcontrib>Missel, P.J.</creatorcontrib><title>Transient Analysis of Ocular Drug Delivery: Zero-Volume Effect</title><title>Journal of pharmaceutical sciences</title><addtitle>J. Pharm. Sci</addtitle><description>Dose volume reduction is one method for reducing the nonproductive loss of ophthalmic drugs caused by premature drainage from the precorneal area. A new mathematical method is presented for calculating the bioavailability enhancement achieved by the dose volume reduction method. This new model suggests that the steady-state assumption used in a previous paper overestimated the bioavailability enhancement, depending upon physical factors such as distribution and diffusion coefficients of the drug in tissue and solution. The analysis shows that transient effects can make a difference up to a complete elimination of the zero-volume effect in those cases where the distribution coefficient is large and the permeability coefficient is small (i.e., for large, lipophilic molecules).</description><subject>Absorption</subject><subject>Biological and medical sciences</subject><subject>Biological Availability</subject><subject>Cornea - metabolism</subject><subject>Dosage Forms</subject><subject>Eye</subject><subject>Eye - metabolism</subject><subject>General pharmacology</subject><subject>Medical sciences</subject><subject>Models, Biological</subject><subject>Ophthalmic Solutions - pharmacokinetics</subject><subject>Pharmacokinetics. Pharmacogenetics. Drug-receptor interactions</subject><subject>Pharmacology. Drug treatments</subject><issn>0022-3549</issn><issn>1520-6017</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1997</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp10U1LJDEQBuAgLjqrHvwBQh9kYcHWfHSSjgdB_JhdERUcFbyETLoi0cy0m0yr8-830sOc9JRDPVRV3kJom-B9gik5eE5KYE7wywoaEE5xKTCRq2iAMaUl45VaRz9TesYYZ8bX0JqiqqqJGqCjUTTT5GE6K46nJsyTT0XrimvbBROL09g9FacQ_BvE-WHxCLEt79vQTaA4cw7sbBP9cCYk2Fq8G-ju_Gx08qe8vB7-PTm-LG1Fa1pWXHDDOBHOceANb4wdNxRLySpGx2IMDVVKEssNdoqKvLFklFQSGqwot4JtoF9939fY_usgzfTEJwshmCm0XdJS0ZoJVmf4u4c2tilFcPo1-omJc02w_sxKL7PKdmfRtBtPoFnKRTi5vruom2RNcDkp69OS0ZoQIT932-vZuw8w_36evri5JTTzsuc-zeBjyU180UIyyfXD1VDX_GokBR5qmT3rPeR83zxEnWy-l4XGx3wB3bT-i7_9B7SFnQA</recordid><startdate>199709</startdate><enddate>199709</enddate><creator>Keister, J.C.</creator><creator>P.S.Heidmann</creator><creator>Missel, P.J.</creator><general>Elsevier Inc</general><general>John Wiley & Sons, Inc</general><general>Wiley</general><general>American Pharmaceutical Association</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>199709</creationdate><title>Transient Analysis of Ocular Drug Delivery: Zero-Volume Effect</title><author>Keister, J.C. ; P.S.Heidmann ; Missel, P.J.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4282-4565a3516ff5e5d5dacbd20773432b6bed29971c5a0f926354732147ed0925c63</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1997</creationdate><topic>Absorption</topic><topic>Biological and medical sciences</topic><topic>Biological Availability</topic><topic>Cornea - metabolism</topic><topic>Dosage Forms</topic><topic>Eye</topic><topic>Eye - metabolism</topic><topic>General pharmacology</topic><topic>Medical sciences</topic><topic>Models, Biological</topic><topic>Ophthalmic Solutions - pharmacokinetics</topic><topic>Pharmacokinetics. Pharmacogenetics. Drug-receptor interactions</topic><topic>Pharmacology. Drug treatments</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Keister, J.C.</creatorcontrib><creatorcontrib>P.S.Heidmann</creatorcontrib><creatorcontrib>Missel, P.J.</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of pharmaceutical sciences</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Keister, J.C.</au><au>P.S.Heidmann</au><au>Missel, P.J.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Transient Analysis of Ocular Drug Delivery: Zero-Volume Effect</atitle><jtitle>Journal of pharmaceutical sciences</jtitle><addtitle>J. Pharm. Sci</addtitle><date>1997-09</date><risdate>1997</risdate><volume>86</volume><issue>9</issue><spage>1040</spage><epage>1045</epage><pages>1040-1045</pages><issn>0022-3549</issn><eissn>1520-6017</eissn><coden>JPMSAE</coden><abstract>Dose volume reduction is one method for reducing the nonproductive loss of ophthalmic drugs caused by premature drainage from the precorneal area. A new mathematical method is presented for calculating the bioavailability enhancement achieved by the dose volume reduction method. This new model suggests that the steady-state assumption used in a previous paper overestimated the bioavailability enhancement, depending upon physical factors such as distribution and diffusion coefficients of the drug in tissue and solution. The analysis shows that transient effects can make a difference up to a complete elimination of the zero-volume effect in those cases where the distribution coefficient is large and the permeability coefficient is small (i.e., for large, lipophilic molecules).</abstract><cop>New York</cop><pub>Elsevier Inc</pub><pmid>9294819</pmid><doi>10.1021/js960510k</doi><tpages>6</tpages></addata></record> |
| fulltext | fulltext |
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| ispartof | Journal of pharmaceutical sciences, 1997-09, Vol.86 (9), p.1040-1045 |
| issn | 0022-3549 1520-6017 |
| language | eng |
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| source | MEDLINE; Wiley Online Library Journals Frontfile Complete; Alma/SFX Local Collection |
| subjects | Absorption Biological and medical sciences Biological Availability Cornea - metabolism Dosage Forms Eye Eye - metabolism General pharmacology Medical sciences Models, Biological Ophthalmic Solutions - pharmacokinetics Pharmacokinetics. Pharmacogenetics. Drug-receptor interactions Pharmacology. Drug treatments |
| title | Transient Analysis of Ocular Drug Delivery: Zero-Volume Effect |
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