Defective TCR-mediated signaling in synovial T cells in rheumatoid arthritis

In rheumatoid arthritis (RA), the functional status of T cells is incompletely understood. Synovial T cells display phenotypic evidence of former activation, but there is poor production of T cell-derived cytokines in the synovium. In addition, synovial T cell proliferation upon mitogenic and antige...

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Veröffentlicht in:	The Journal of immunology (1950) 1997-09, Vol.159 (6), p.2973-2978
Hauptverfasser:	Maurice, MM, Lankester, AC, Bezemer, AC, Geertsma, MF, Tak, PP, Breedveld, FC, van Lier, RA, Verweij, CL
Format:	Artikel
Sprache:	eng
Schlagworte:	Arthritis, Rheumatoid - immunology Cells, Cultured Flow Cytometry Humans Immunohistochemistry Membrane Proteins - immunology Receptors, Antigen, T-Cell - immunology Signal Transduction - immunology Synovial Membrane - immunology T-Lymphocytes - immunology
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