Impaired Reflex Response to Volume Expansion in NaCl-Sensitive Spontaneously Hypertensive Rats
Abnormal baroreceptor reflex function that antedates or is a consequence of NaCl loading could contribute to the NaCI-induced exacerbation of hypertension in NaCI-sensitive spontaneously hypertensive rats (SHR-S). The current study tested the hypothesis that an impairment in cardiopulmonary barorece...
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| Veröffentlicht in: | Hypertension (Dallas, Tex. 1979) Tex. 1979), 1989-11, Vol.14 (5), p.518-523 |
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| container_title | Hypertension (Dallas, Tex. 1979) |
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| creator | Thornton, Richard M Wyss, J Michael Oparil, Suzanne |
| description | Abnormal baroreceptor reflex function that antedates or is a consequence of NaCl loading could contribute to the NaCI-induced exacerbation of hypertension in NaCI-sensitive spontaneously hypertensive rats (SHR-S). The current study tested the hypothesis that an impairment in cardiopulmonary baroreceptor reflex function exists in SHR-S before NaCl loading. The reflex response to volume expansion was compared in SHR-S, NaCI-resistant SHR (SHR-R), and normotensive Wistar-Kyoto (WKY) and Sprague-Dawley rats maintained on a normal NaCl diet. Conscious, free-moving SHR-S, SHR-R, WKY, and Sprague-Dawley rats were volume expanded with whole blood to 15% of blood volume within 6 minutes, and mean arterial pressure, heart rate, and lumbar sympathetic nerve activity were recorded. Heart rate and lumbar sympathetic nerve activity decreased significantly in SHR-R, WKY, and Sprague- Dawley rats after volume expansion. In contrast, in SHR-S neither heart rate after volume expansion nor lumbar sympathetic nerve activity was significantly different from levels before volume expansion. The blunted reflex response of heart rate and lumbar sympathetic nerve activity to volume expansion suggests impaired cardiopulmonary volume receptor function in SHR-S. This likely contributes to NaCI-induced hypertension in SHR-S on a high NaCl diet. |
| doi_str_mv | 10.1161/01.hyp.14.5.518 |
| format | Article |
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The current study tested the hypothesis that an impairment in cardiopulmonary baroreceptor reflex function exists in SHR-S before NaCl loading. The reflex response to volume expansion was compared in SHR-S, NaCI-resistant SHR (SHR-R), and normotensive Wistar-Kyoto (WKY) and Sprague-Dawley rats maintained on a normal NaCl diet. Conscious, free-moving SHR-S, SHR-R, WKY, and Sprague-Dawley rats were volume expanded with whole blood to 15% of blood volume within 6 minutes, and mean arterial pressure, heart rate, and lumbar sympathetic nerve activity were recorded. Heart rate and lumbar sympathetic nerve activity decreased significantly in SHR-R, WKY, and Sprague- Dawley rats after volume expansion. In contrast, in SHR-S neither heart rate after volume expansion nor lumbar sympathetic nerve activity was significantly different from levels before volume expansion. The blunted reflex response of heart rate and lumbar sympathetic nerve activity to volume expansion suggests impaired cardiopulmonary volume receptor function in SHR-S. This likely contributes to NaCI-induced hypertension in SHR-S on a high NaCl diet.</description><identifier>ISSN: 0194-911X</identifier><identifier>EISSN: 1524-4563</identifier><identifier>DOI: 10.1161/01.hyp.14.5.518</identifier><identifier>PMID: 2807513</identifier><identifier>CODEN: HPRTDN</identifier><language>eng</language><publisher>Philadelphia, PA: American Heart Association, Inc</publisher><subject>Animals ; Arterial hypertension. Arterial hypotension ; Biological and medical sciences ; Blood and lymphatic vessels ; Blood Pressure ; Cardiology. Vascular system ; Drug Resistance ; Experimental diseases ; Heart Rate - drug effects ; Lumbosacral Region ; Male ; Medical sciences ; Norepinephrine - blood ; Plasma Substitutes - pharmacology ; Pressoreceptors - physiology ; Rats ; Rats, Inbred SHR - blood ; Rats, Inbred SHR - physiology ; Rats, Inbred Strains - physiology ; Rats, Inbred WKY ; Reflex - physiology ; Sodium Chloride - pharmacology ; Sympathetic Nervous System - physiology</subject><ispartof>Hypertension (Dallas, Tex. 1979), 1989-11, Vol.14 (5), p.518-523</ispartof><rights>1989 American Heart Association, Inc.</rights><rights>1990 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c5149-d6c8f5bd4f4cd9a8088f5a26c92b8149b851051fec028544a60af858933fc71b3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,3674,27901,27902</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=6627821$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/2807513$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Thornton, Richard M</creatorcontrib><creatorcontrib>Wyss, J Michael</creatorcontrib><creatorcontrib>Oparil, Suzanne</creatorcontrib><title>Impaired Reflex Response to Volume Expansion in NaCl-Sensitive Spontaneously Hypertensive Rats</title><title>Hypertension (Dallas, Tex. 1979)</title><addtitle>Hypertension</addtitle><description>Abnormal baroreceptor reflex function that antedates or is a consequence of NaCl loading could contribute to the NaCI-induced exacerbation of hypertension in NaCI-sensitive spontaneously hypertensive rats (SHR-S). The current study tested the hypothesis that an impairment in cardiopulmonary baroreceptor reflex function exists in SHR-S before NaCl loading. The reflex response to volume expansion was compared in SHR-S, NaCI-resistant SHR (SHR-R), and normotensive Wistar-Kyoto (WKY) and Sprague-Dawley rats maintained on a normal NaCl diet. Conscious, free-moving SHR-S, SHR-R, WKY, and Sprague-Dawley rats were volume expanded with whole blood to 15% of blood volume within 6 minutes, and mean arterial pressure, heart rate, and lumbar sympathetic nerve activity were recorded. Heart rate and lumbar sympathetic nerve activity decreased significantly in SHR-R, WKY, and Sprague- Dawley rats after volume expansion. In contrast, in SHR-S neither heart rate after volume expansion nor lumbar sympathetic nerve activity was significantly different from levels before volume expansion. The blunted reflex response of heart rate and lumbar sympathetic nerve activity to volume expansion suggests impaired cardiopulmonary volume receptor function in SHR-S. This likely contributes to NaCI-induced hypertension in SHR-S on a high NaCl diet.</description><subject>Animals</subject><subject>Arterial hypertension. Arterial hypotension</subject><subject>Biological and medical sciences</subject><subject>Blood and lymphatic vessels</subject><subject>Blood Pressure</subject><subject>Cardiology. Vascular system</subject><subject>Drug Resistance</subject><subject>Experimental diseases</subject><subject>Heart Rate - drug effects</subject><subject>Lumbosacral Region</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Norepinephrine - blood</subject><subject>Plasma Substitutes - pharmacology</subject><subject>Pressoreceptors - physiology</subject><subject>Rats</subject><subject>Rats, Inbred SHR - blood</subject><subject>Rats, Inbred SHR - physiology</subject><subject>Rats, Inbred Strains - physiology</subject><subject>Rats, Inbred WKY</subject><subject>Reflex - physiology</subject><subject>Sodium Chloride - pharmacology</subject><subject>Sympathetic Nervous System - physiology</subject><issn>0194-911X</issn><issn>1524-4563</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1989</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo9kc1v1DAQxa0KVLaFMyekHBC3pB7HTuwjWhW2UgWohapcajnOWBtwPrCTtvvf49Wu6svo-f1mxnom5D3QAqCCCwrFdjcVwAtRCJAnZAWC8ZyLqnxFVhQUzxXA_RtyFuMfSoFzXp-SUyZpLaBckYerfjJdwDa7QefxOZU4jUPEbB6zu9EvPWaXz5MZYjcOWTdk38za57eY9Nw9Ynab4NkMOC7R77LNbsIw781k3Zg5viWvnfER3x3rOfn15fLnepNff_96tf58nVsBXOVtZaUTTcsdt60yksokDausYo1MQCMFUAEOLWVScG4qapwUUpWlszU05Tn5dJg7hfHfgnHWfRcten94mq4Vk6kTEnhxAG0YYwzo9BS63oSdBqr3iWoKevP7hwauhU6Jpo4Px9FL02P7wh8jTP7Ho2-iNd4FM9guvmBVxWrJ9ov5AXsa_Ywh_vXLEwa9RePnrabpcFbJHJRM_5VUvr9S5X_eJI6s</recordid><startdate>198911</startdate><enddate>198911</enddate><creator>Thornton, Richard M</creator><creator>Wyss, J Michael</creator><creator>Oparil, Suzanne</creator><general>American Heart Association, Inc</general><general>Lippincott</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>198911</creationdate><title>Impaired Reflex Response to Volume Expansion in NaCl-Sensitive Spontaneously Hypertensive Rats</title><author>Thornton, Richard M ; Wyss, J Michael ; Oparil, Suzanne</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5149-d6c8f5bd4f4cd9a8088f5a26c92b8149b851051fec028544a60af858933fc71b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1989</creationdate><topic>Animals</topic><topic>Arterial hypertension. Arterial hypotension</topic><topic>Biological and medical sciences</topic><topic>Blood and lymphatic vessels</topic><topic>Blood Pressure</topic><topic>Cardiology. Vascular system</topic><topic>Drug Resistance</topic><topic>Experimental diseases</topic><topic>Heart Rate - drug effects</topic><topic>Lumbosacral Region</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Norepinephrine - blood</topic><topic>Plasma Substitutes - pharmacology</topic><topic>Pressoreceptors - physiology</topic><topic>Rats</topic><topic>Rats, Inbred SHR - blood</topic><topic>Rats, Inbred SHR - physiology</topic><topic>Rats, Inbred Strains - physiology</topic><topic>Rats, Inbred WKY</topic><topic>Reflex - physiology</topic><topic>Sodium Chloride - pharmacology</topic><topic>Sympathetic Nervous System - physiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Thornton, Richard M</creatorcontrib><creatorcontrib>Wyss, J Michael</creatorcontrib><creatorcontrib>Oparil, Suzanne</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Hypertension (Dallas, Tex. 1979)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Thornton, Richard M</au><au>Wyss, J Michael</au><au>Oparil, Suzanne</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Impaired Reflex Response to Volume Expansion in NaCl-Sensitive Spontaneously Hypertensive Rats</atitle><jtitle>Hypertension (Dallas, Tex. 1979)</jtitle><addtitle>Hypertension</addtitle><date>1989-11</date><risdate>1989</risdate><volume>14</volume><issue>5</issue><spage>518</spage><epage>523</epage><pages>518-523</pages><issn>0194-911X</issn><eissn>1524-4563</eissn><coden>HPRTDN</coden><abstract>Abnormal baroreceptor reflex function that antedates or is a consequence of NaCl loading could contribute to the NaCI-induced exacerbation of hypertension in NaCI-sensitive spontaneously hypertensive rats (SHR-S). The current study tested the hypothesis that an impairment in cardiopulmonary baroreceptor reflex function exists in SHR-S before NaCl loading. The reflex response to volume expansion was compared in SHR-S, NaCI-resistant SHR (SHR-R), and normotensive Wistar-Kyoto (WKY) and Sprague-Dawley rats maintained on a normal NaCl diet. Conscious, free-moving SHR-S, SHR-R, WKY, and Sprague-Dawley rats were volume expanded with whole blood to 15% of blood volume within 6 minutes, and mean arterial pressure, heart rate, and lumbar sympathetic nerve activity were recorded. Heart rate and lumbar sympathetic nerve activity decreased significantly in SHR-R, WKY, and Sprague- Dawley rats after volume expansion. In contrast, in SHR-S neither heart rate after volume expansion nor lumbar sympathetic nerve activity was significantly different from levels before volume expansion. The blunted reflex response of heart rate and lumbar sympathetic nerve activity to volume expansion suggests impaired cardiopulmonary volume receptor function in SHR-S. This likely contributes to NaCI-induced hypertension in SHR-S on a high NaCl diet.</abstract><cop>Philadelphia, PA</cop><cop>Hagerstown, MD</cop><pub>American Heart Association, Inc</pub><pmid>2807513</pmid><doi>10.1161/01.hyp.14.5.518</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; American Heart Association Journals; EZB-FREE-00999 freely available EZB journals; Journals@Ovid Complete |
| subjects | Animals Arterial hypertension. Arterial hypotension Biological and medical sciences Blood and lymphatic vessels Blood Pressure Cardiology. Vascular system Drug Resistance Experimental diseases Heart Rate - drug effects Lumbosacral Region Male Medical sciences Norepinephrine - blood Plasma Substitutes - pharmacology Pressoreceptors - physiology Rats Rats, Inbred SHR - blood Rats, Inbred SHR - physiology Rats, Inbred Strains - physiology Rats, Inbred WKY Reflex - physiology Sodium Chloride - pharmacology Sympathetic Nervous System - physiology |
| title | Impaired Reflex Response to Volume Expansion in NaCl-Sensitive Spontaneously Hypertensive Rats |
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