RTN TRH causes prolonged respiratory stimulation
Carlos L. Cream, Aihua Li, and Eugene E. Nattie Department of Physiology, Dartmouth Medical School, Lebanon, New Hampshire 03756-0001 Received 6 March 1997; accepted in final form 30 April 1997. Cream, Carlos L., Aihua Li, and Eugene E. Nattie. RTN TRH causes prolonged respiratory stimulation. J. Ap...
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| creator | Cream, Carlos L Li, Aihua Nattie, Eugene E |
| description | Carlos L.
Cream,
Aihua
Li, and
Eugene E.
Nattie
Department of Physiology, Dartmouth Medical School, Lebanon, New
Hampshire 03756-0001
Received 6 March 1997; accepted in final form 30 April 1997.
Cream, Carlos L., Aihua Li, and Eugene E. Nattie. RTN
TRH causes prolonged respiratory stimulation. J. Appl.
Physiol. 83(3): 792-799, 1997. We injected
thyrotropin-releasing hormone (TRH; 10 nl; 0.25, 0.5, 1.0, or 10 mM),
its inactive free acid form (TRHOH; 1 mM), or a metabolite with low
TRH-receptor binding affinity, histidine-proline diketopiperazine (cHP;
1 mM), into the retrotrapezoid nucleus of anesthetized rats. Injection
location was verified by anatomic analysis. Lower doses (0.25-0.5
mM) significantly increased both the product of integrated phrenic
amplitude and frequency
( Phr · f) and f for 20-30
min compared with artificial cerebrospinal fluid control injections. Higher doses (1.0-10 mM) produced greater and long-lasting
stimulation of Phr · f,
Phr, and f and of blood pressure. This
stimulation reached values 150% of baseline and durations of 270 min
after a single injection. TRHOH (1 mM ) or cHP (1 mM) had no effect on
Phr but increased f, as did 1 mM TRH. We conclude
that TRH has a very powerful stimulatory effect in the retrotrapezoid
nucleus region on Phr · f, with
the Phr response seemingly specific for TRH
receptors. Similar responses of f to TRHOH and cHP suggest it may be
nonspecific.
control of breathing; ventrolateral medulla; thyrotropin-releasing
hormone free acid; histidine-proline diketopiperazine; blood pressure; respiratory regulation; retrotrapezoid nucleus
0161-7567/97 $5.00
Copyright © 1997 the American Physiological Society |
| doi_str_mv | 10.1152/jappl.1997.83.3.792 |
| format | Article |
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Cream,
Aihua
Li, and
Eugene E.
Nattie
Department of Physiology, Dartmouth Medical School, Lebanon, New
Hampshire 03756-0001
Received 6 March 1997; accepted in final form 30 April 1997.
Cream, Carlos L., Aihua Li, and Eugene E. Nattie. RTN
TRH causes prolonged respiratory stimulation. J. Appl.
Physiol. 83(3): 792-799, 1997. We injected
thyrotropin-releasing hormone (TRH; 10 nl; 0.25, 0.5, 1.0, or 10 mM),
its inactive free acid form (TRHOH; 1 mM), or a metabolite with low
TRH-receptor binding affinity, histidine-proline diketopiperazine (cHP;
1 mM), into the retrotrapezoid nucleus of anesthetized rats. Injection
location was verified by anatomic analysis. Lower doses (0.25-0.5
mM) significantly increased both the product of integrated phrenic
amplitude and frequency
( Phr · f) and f for 20-30
min compared with artificial cerebrospinal fluid control injections. Higher doses (1.0-10 mM) produced greater and long-lasting
stimulation of Phr · f,
Phr, and f and of blood pressure. This
stimulation reached values 150% of baseline and durations of 270 min
after a single injection. TRHOH (1 mM ) or cHP (1 mM) had no effect on
Phr but increased f, as did 1 mM TRH. We conclude
that TRH has a very powerful stimulatory effect in the retrotrapezoid
nucleus region on Phr · f, with
the Phr response seemingly specific for TRH
receptors. Similar responses of f to TRHOH and cHP suggest it may be
nonspecific.
control of breathing; ventrolateral medulla; thyrotropin-releasing
hormone free acid; histidine-proline diketopiperazine; blood pressure; respiratory regulation; retrotrapezoid nucleus
0161-7567/97 $5.00
Copyright © 1997 the American Physiological Society</description><identifier>ISSN: 8750-7587</identifier><identifier>EISSN: 1522-1601</identifier><identifier>DOI: 10.1152/jappl.1997.83.3.792</identifier><identifier>PMID: 9292465</identifier><identifier>CODEN: JAPHEV</identifier><language>eng</language><publisher>Bethesda, MD: Am Physiological Soc</publisher><subject>Animals ; Biological and medical sciences ; Blood Pressure - drug effects ; Cardiorespiratory control. Arterial mecano- and chemoreceptor ; Fundamental and applied biological sciences. Psychology ; Male ; Medulla Oblongata - drug effects ; Medulla Oblongata - physiology ; Microinjections ; Phrenic Nerve - drug effects ; Phrenic Nerve - physiology ; Rats ; Rats, Sprague-Dawley ; Respiratory Function Tests ; Respiratory System - drug effects ; Stimulation, Chemical ; Thyrotropin-Releasing Hormone - pharmacology ; Vertebrates: respiratory system</subject><ispartof>Journal of applied physiology (1985), 1997-09, Vol.83 (3), p.792-799</ispartof><rights>1997 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c405t-e5f45c6d6f3e6d0fadcd53c676f987b6106aec7f13bd66312dc4a8c1cfb6b0b23</citedby><cites>FETCH-LOGICAL-c405t-e5f45c6d6f3e6d0fadcd53c676f987b6106aec7f13bd66312dc4a8c1cfb6b0b23</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,3039,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=2821347$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/9292465$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Cream, Carlos L</creatorcontrib><creatorcontrib>Li, Aihua</creatorcontrib><creatorcontrib>Nattie, Eugene E</creatorcontrib><title>RTN TRH causes prolonged respiratory stimulation</title><title>Journal of applied physiology (1985)</title><addtitle>J Appl Physiol (1985)</addtitle><description>Carlos L.
Cream,
Aihua
Li, and
Eugene E.
Nattie
Department of Physiology, Dartmouth Medical School, Lebanon, New
Hampshire 03756-0001
Received 6 March 1997; accepted in final form 30 April 1997.
Cream, Carlos L., Aihua Li, and Eugene E. Nattie. RTN
TRH causes prolonged respiratory stimulation. J. Appl.
Physiol. 83(3): 792-799, 1997. We injected
thyrotropin-releasing hormone (TRH; 10 nl; 0.25, 0.5, 1.0, or 10 mM),
its inactive free acid form (TRHOH; 1 mM), or a metabolite with low
TRH-receptor binding affinity, histidine-proline diketopiperazine (cHP;
1 mM), into the retrotrapezoid nucleus of anesthetized rats. Injection
location was verified by anatomic analysis. Lower doses (0.25-0.5
mM) significantly increased both the product of integrated phrenic
amplitude and frequency
( Phr · f) and f for 20-30
min compared with artificial cerebrospinal fluid control injections. Higher doses (1.0-10 mM) produced greater and long-lasting
stimulation of Phr · f,
Phr, and f and of blood pressure. This
stimulation reached values 150% of baseline and durations of 270 min
after a single injection. TRHOH (1 mM ) or cHP (1 mM) had no effect on
Phr but increased f, as did 1 mM TRH. We conclude
that TRH has a very powerful stimulatory effect in the retrotrapezoid
nucleus region on Phr · f, with
the Phr response seemingly specific for TRH
receptors. Similar responses of f to TRHOH and cHP suggest it may be
nonspecific.
control of breathing; ventrolateral medulla; thyrotropin-releasing
hormone free acid; histidine-proline diketopiperazine; blood pressure; respiratory regulation; retrotrapezoid nucleus
0161-7567/97 $5.00
Copyright © 1997 the American Physiological Society</description><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Blood Pressure - drug effects</subject><subject>Cardiorespiratory control. Arterial mecano- and chemoreceptor</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Male</subject><subject>Medulla Oblongata - drug effects</subject><subject>Medulla Oblongata - physiology</subject><subject>Microinjections</subject><subject>Phrenic Nerve - drug effects</subject><subject>Phrenic Nerve - physiology</subject><subject>Rats</subject><subject>Rats, Sprague-Dawley</subject><subject>Respiratory Function Tests</subject><subject>Respiratory System - drug effects</subject><subject>Stimulation, Chemical</subject><subject>Thyrotropin-Releasing Hormone - pharmacology</subject><subject>Vertebrates: respiratory system</subject><issn>8750-7587</issn><issn>1522-1601</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1997</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kEtLxDAUhYMoOj5-gQhdiK5a82iSdimDLxAFGdchzWMmkpnWpEXn35s6o7hxdRfnO-feewA4RbBAiOKrN9l1vkB1zYuKFKTgNd4Bk6TgHDGIdsGk4hTmnFb8ABzG-AYhKkuK9sF-jWtcMjoB8GX2lM1e7jMlh2hi1oXWt6u50VkwsXNB9m1YZ7F3y8HL3rWrY7BnpY_mZDuPwOvtzWx6nz8-3z1Mrx9zVULa54bakiqmmSWGaWilVpoSxTizdcUbhiCTRnGLSKMZIwhrVcpKIWUb1sAGkyNwsclNF70PJvZi6aIy3suVaYco0rNVCmEJJBtQhTbGYKzoglvKsBYIirEn8d2TGHsSFRFktCbX2TZ-aJZG_3q2xST9fKvLqKS3Qa6Ui78YrjAiJU_Y5QZbuPniwwUjusU6utThfD3u_buQ_E_eDt7PzGc_Wn4cotOWfAEcCZLz</recordid><startdate>19970901</startdate><enddate>19970901</enddate><creator>Cream, Carlos L</creator><creator>Li, Aihua</creator><creator>Nattie, Eugene E</creator><general>Am Physiological Soc</general><general>American Physiological Society</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19970901</creationdate><title>RTN TRH causes prolonged respiratory stimulation</title><author>Cream, Carlos L ; Li, Aihua ; Nattie, Eugene E</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c405t-e5f45c6d6f3e6d0fadcd53c676f987b6106aec7f13bd66312dc4a8c1cfb6b0b23</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1997</creationdate><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Blood Pressure - drug effects</topic><topic>Cardiorespiratory control. Arterial mecano- and chemoreceptor</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Male</topic><topic>Medulla Oblongata - drug effects</topic><topic>Medulla Oblongata - physiology</topic><topic>Microinjections</topic><topic>Phrenic Nerve - drug effects</topic><topic>Phrenic Nerve - physiology</topic><topic>Rats</topic><topic>Rats, Sprague-Dawley</topic><topic>Respiratory Function Tests</topic><topic>Respiratory System - drug effects</topic><topic>Stimulation, Chemical</topic><topic>Thyrotropin-Releasing Hormone - pharmacology</topic><topic>Vertebrates: respiratory system</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Cream, Carlos L</creatorcontrib><creatorcontrib>Li, Aihua</creatorcontrib><creatorcontrib>Nattie, Eugene E</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of applied physiology (1985)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Cream, Carlos L</au><au>Li, Aihua</au><au>Nattie, Eugene E</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>RTN TRH causes prolonged respiratory stimulation</atitle><jtitle>Journal of applied physiology (1985)</jtitle><addtitle>J Appl Physiol (1985)</addtitle><date>1997-09-01</date><risdate>1997</risdate><volume>83</volume><issue>3</issue><spage>792</spage><epage>799</epage><pages>792-799</pages><issn>8750-7587</issn><eissn>1522-1601</eissn><coden>JAPHEV</coden><abstract>Carlos L.
Cream,
Aihua
Li, and
Eugene E.
Nattie
Department of Physiology, Dartmouth Medical School, Lebanon, New
Hampshire 03756-0001
Received 6 March 1997; accepted in final form 30 April 1997.
Cream, Carlos L., Aihua Li, and Eugene E. Nattie. RTN
TRH causes prolonged respiratory stimulation. J. Appl.
Physiol. 83(3): 792-799, 1997. We injected
thyrotropin-releasing hormone (TRH; 10 nl; 0.25, 0.5, 1.0, or 10 mM),
its inactive free acid form (TRHOH; 1 mM), or a metabolite with low
TRH-receptor binding affinity, histidine-proline diketopiperazine (cHP;
1 mM), into the retrotrapezoid nucleus of anesthetized rats. Injection
location was verified by anatomic analysis. Lower doses (0.25-0.5
mM) significantly increased both the product of integrated phrenic
amplitude and frequency
( Phr · f) and f for 20-30
min compared with artificial cerebrospinal fluid control injections. Higher doses (1.0-10 mM) produced greater and long-lasting
stimulation of Phr · f,
Phr, and f and of blood pressure. This
stimulation reached values 150% of baseline and durations of 270 min
after a single injection. TRHOH (1 mM ) or cHP (1 mM) had no effect on
Phr but increased f, as did 1 mM TRH. We conclude
that TRH has a very powerful stimulatory effect in the retrotrapezoid
nucleus region on Phr · f, with
the Phr response seemingly specific for TRH
receptors. Similar responses of f to TRHOH and cHP suggest it may be
nonspecific.
control of breathing; ventrolateral medulla; thyrotropin-releasing
hormone free acid; histidine-proline diketopiperazine; blood pressure; respiratory regulation; retrotrapezoid nucleus
0161-7567/97 $5.00
Copyright © 1997 the American Physiological Society</abstract><cop>Bethesda, MD</cop><pub>Am Physiological Soc</pub><pmid>9292465</pmid><doi>10.1152/jappl.1997.83.3.792</doi><tpages>8</tpages></addata></record> |
| fulltext | fulltext |
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| ispartof | Journal of applied physiology (1985), 1997-09, Vol.83 (3), p.792-799 |
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| language | eng |
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| source | MEDLINE; American Physiological Society; EZB-FREE-00999 freely available EZB journals; Alma/SFX Local Collection |
| subjects | Animals Biological and medical sciences Blood Pressure - drug effects Cardiorespiratory control. Arterial mecano- and chemoreceptor Fundamental and applied biological sciences. Psychology Male Medulla Oblongata - drug effects Medulla Oblongata - physiology Microinjections Phrenic Nerve - drug effects Phrenic Nerve - physiology Rats Rats, Sprague-Dawley Respiratory Function Tests Respiratory System - drug effects Stimulation, Chemical Thyrotropin-Releasing Hormone - pharmacology Vertebrates: respiratory system |
| title | RTN TRH causes prolonged respiratory stimulation |
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