Central administration of p-octopamine to mice: assessment of antinociception

Administration of p-octopamine by intracerebroventricular (i.c.v.) or intrathecal (i.t.) routes, but not orally, produced antinociception in the acetylcholine-induced abdominal constriction test (ED 50 = 24.8 and 3.6 μg, respectively). Likewise, i.c.v. and i.t., but not peripheral (up to 200 mg/kg s...

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