Antipsychotic substances and dopamine in the rat brain; behavioral studies reveal distinct dopamine receptor systems

Graded doses of apomorphine were injected into terminal areas of the nigrostriatal, mesolimbic and mesocortical dopamine (DA) systems of the rat brain. Injection of high doses of apomorphine into the nucleus caudatus elicited stereotyped sniffing, but did not affect the motility of the rat. Low and...

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Veröffentlicht in:	European journal of pharmacology 1989-08, Vol.166 (3), p.441-452
Hauptverfasser:	Van Ree, Jan M., Elands, Jack, Király, Ildiko, Wolterink, Gerrit
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antipsychotic Agents - administration & dosage Antipsychotic Agents - pharmacology Antipsychotic substances Apomorphine - administration & dosage Apomorphine - pharmacology Behavior, Animal - drug effects beta-Endorphin - administration & dosage beta-Endorphin - pharmacology Biological and medical sciences Brain Chemistry - drug effects Brain regions Cerebral Cortex - anatomy & histology Corpus Striatum - anatomy & histology Desenkephalin-γ-endorphin (DEγE) Dopamine Dopamine - metabolism Dose-Response Relationship, Drug Haloperidol Injections Male Medical sciences Motor Activity - drug effects Neuropharmacology Pharmacology. Drug treatments Psycholeptics: tranquillizer, neuroleptic Psychology. Psychoanalysis. Psychiatry Psychopharmacology Rats Rats, Inbred Strains Receptors, Dopamine - drug effects Substantia Nigra - anatomy & histology Sulpiride Sulpiride - administration & dosage Sulpiride - pharmacology
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