Antifibrinolytic drugs and perioperative hemostasis
Although excessive bleeding is widely recognized as a common complication of cardiac surgery, the recent success of antifibrinolytic drugs as prophylactic hemostatic agents has received little attention outside the surgical literature. The etiology of the coagulopathy following cardiac surgery is cl...
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| Veröffentlicht in: | American journal of hematology 1997-09, Vol.56 (1), p.32-36 |
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| container_title | American journal of hematology |
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| creator | Slaughter, Thomas F. Greenberg, Charles S. |
| description | Although excessive bleeding is widely recognized as a common complication of cardiac surgery, the recent success of antifibrinolytic drugs as prophylactic hemostatic agents has received little attention outside the surgical literature. The etiology of the coagulopathy following cardiac surgery is clearly multifactorial; however, the success of antifibrinolytic drugs as hemostatic agents suggests that fibrinolysis contributes to bleeding in this setting. Increasingly widespread administration of these drugs necessitates increased awareness of the risks and benefits posed by perioperative antifibrinolytic therapy. The objectives of this review are to understand the mechanisms of action of antifibrinolytic drugs in the context of the normal hemostatic response and to review evidence pertaining to the efficacy and safety of antifibrinolytic drugs as hemostatic agents during cardiac surgery. Am. J. Hematol. 56:32–36, 1997. © 1997 Wiley‐Liss, Inc. |
| doi_str_mv | 10.1002/(SICI)1096-8652(199709)56:1<32::AID-AJH7>3.0.CO;2-3 |
| format | Article |
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The etiology of the coagulopathy following cardiac surgery is clearly multifactorial; however, the success of antifibrinolytic drugs as hemostatic agents suggests that fibrinolysis contributes to bleeding in this setting. Increasingly widespread administration of these drugs necessitates increased awareness of the risks and benefits posed by perioperative antifibrinolytic therapy. The objectives of this review are to understand the mechanisms of action of antifibrinolytic drugs in the context of the normal hemostatic response and to review evidence pertaining to the efficacy and safety of antifibrinolytic drugs as hemostatic agents during cardiac surgery. Am. J. 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The etiology of the coagulopathy following cardiac surgery is clearly multifactorial; however, the success of antifibrinolytic drugs as hemostatic agents suggests that fibrinolysis contributes to bleeding in this setting. Increasingly widespread administration of these drugs necessitates increased awareness of the risks and benefits posed by perioperative antifibrinolytic therapy. The objectives of this review are to understand the mechanisms of action of antifibrinolytic drugs in the context of the normal hemostatic response and to review evidence pertaining to the efficacy and safety of antifibrinolytic drugs as hemostatic agents during cardiac surgery. Am. J. Hematol. 56:32–36, 1997. © 1997 Wiley‐Liss, Inc.</description><subject>Antifibrinolytic Agents - therapeutic use</subject><subject>antifibrinolytic drugs</subject><subject>Biological and medical sciences</subject><subject>Blood Loss, Surgical - prevention & control</subject><subject>Blood. Blood coagulation. Reticuloendothelial system</subject><subject>cardiac surgery</subject><subject>Cardiac Surgical Procedures</subject><subject>extracorporeal circulation</subject><subject>Hemostasis - drug effects</subject><subject>Humans</subject><subject>Medical sciences</subject><subject>Pharmacology. Drug treatments</subject><subject>Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases</subject><subject>Surgery of the heart</subject><subject>surgical hemostasis</subject><issn>0361-8609</issn><issn>1096-8652</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1997</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kM1OGzEUha2KigbaR0DKAiFYTLi2M_4JCCma_hCElAVlfeXM2K3RZCbYE1Devp4mShegbq5tnaPrTx8hVxRGFIBdnj_MitkFBS0yJXJ2TrWWoC9yMaHXnE0m09nXbHp3K2_4CEbF_Ipl_AMZ7PsHZABc0HQH_YkcxfgEQOlYwSE51Eyr1BkQPm067_wi-KatN50vh1VY_4pD01TDlQ2-TcN0_sUOf9tlGzsTffxMPjpTR_tldx6Tx-_ffha32f38x6yY3mcll1JmzjCgAoRweRqVsGDBKJMAhOBOGm4ddWLBSwOVUUpWMheOizFXbKF0XvJjcrbduwrt89rGDpc-lrauTWPbdUSpmYKx1Kn4sC2WoY0xWIer4JcmbJAC9ioRe5XYq8FeDW5VYi6QIk9xUom9SuQIWMyRIU9bT3bfrxdLW-137tyl_HSXm1ia2gXTlD7ua4lNKD3-B_fqa7t5Q_Z_sHe4_r75H6DQmYw</recordid><startdate>199709</startdate><enddate>199709</enddate><creator>Slaughter, Thomas F.</creator><creator>Greenberg, Charles S.</creator><general>Wiley Subscription Services, Inc., A Wiley Company</general><general>Wiley-Liss</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>199709</creationdate><title>Antifibrinolytic drugs and perioperative hemostasis</title><author>Slaughter, Thomas F. ; Greenberg, Charles S.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3777-fa2016066f5066d6e0e0a8a480663f7a3ef1f6b3ca0da887d756f364382b895c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1997</creationdate><topic>Antifibrinolytic Agents - therapeutic use</topic><topic>antifibrinolytic drugs</topic><topic>Biological and medical sciences</topic><topic>Blood Loss, Surgical - prevention & control</topic><topic>Blood. Blood coagulation. Reticuloendothelial system</topic><topic>cardiac surgery</topic><topic>Cardiac Surgical Procedures</topic><topic>extracorporeal circulation</topic><topic>Hemostasis - drug effects</topic><topic>Humans</topic><topic>Medical sciences</topic><topic>Pharmacology. Drug treatments</topic><topic>Surgery (general aspects). Transplantations, organ and tissue grafts. 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The etiology of the coagulopathy following cardiac surgery is clearly multifactorial; however, the success of antifibrinolytic drugs as hemostatic agents suggests that fibrinolysis contributes to bleeding in this setting. Increasingly widespread administration of these drugs necessitates increased awareness of the risks and benefits posed by perioperative antifibrinolytic therapy. The objectives of this review are to understand the mechanisms of action of antifibrinolytic drugs in the context of the normal hemostatic response and to review evidence pertaining to the efficacy and safety of antifibrinolytic drugs as hemostatic agents during cardiac surgery. Am. J. Hematol. 56:32–36, 1997. © 1997 Wiley‐Liss, Inc.</abstract><cop>New York</cop><pub>Wiley Subscription Services, Inc., A Wiley Company</pub><pmid>9298865</pmid><doi>10.1002/(SICI)1096-8652(199709)56:1<32::AID-AJH7>3.0.CO;2-3</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | American journal of hematology, 1997-09, Vol.56 (1), p.32-36 |
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| subjects | Antifibrinolytic Agents - therapeutic use antifibrinolytic drugs Biological and medical sciences Blood Loss, Surgical - prevention & control Blood. Blood coagulation. Reticuloendothelial system cardiac surgery Cardiac Surgical Procedures extracorporeal circulation Hemostasis - drug effects Humans Medical sciences Pharmacology. Drug treatments Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases Surgery of the heart surgical hemostasis |
| title | Antifibrinolytic drugs and perioperative hemostasis |
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