Decreased Cardiac Concentration of cGMP Kinase in Hypertensive Animals An Index for Cardiac Vascularization?

Cyclic GMP (cGMP) kinase is ultimately involved in the regulation of vascular smooth muscle tone. Its tissue concentration was determined in normotensive and hypertensive rats by use of monospecinc antJ-cGMP kinase antibodies. Hearts of spontaneously hypertensive rats and renovascular (Goldblatt II)...

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Veröffentlicht in:	Circulation research 1989-11, Vol.65 (5), p.1361-1369
Hauptverfasser:	Ecker, Thomas, Gobel, Claus, Hullin, Roger, Rettig, Rainer, Seitz, Gerhard, Hofmann, Franz
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antibody Specificity Arterial hypertension. Arterial hypotension Biological and medical sciences Blood and lymphatic vessels Blood Vessels - pathology Cardiology. Vascular system Cardiomegaly - etiology Coronary Circulation cyclic GMP kinase Experimental diseases Female hypertension Hypertension - enzymology Hypertension, Renovascular - complications Hypertension, Renovascular - enzymology Immunohistochemistry Medical sciences Myocardium - enzymology Osmolar Concentration Protein Kinases - metabolism Rats Rats, Inbred SHR Rats, Inbred WKY Tissue Distribution
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