Antigen Processing Differences Among APC
The hierarchy of display of determinants on a protein antigen is of critical importance with respect to which T cells will be selected during thymic development, as well as in the induction of mature responses. Activation of T cells will be dependent on unfolding, reduction and chain cleavage of the...
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| Veröffentlicht in: | Human Immunology 1997-05, Vol.54 (2), p.148-158 |
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| container_title | Human Immunology |
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| creator | Schneider, S.C. Sercarz, E.E. |
| description | The hierarchy of display of determinants on a protein antigen is of critical importance with respect to which T cells will be selected during thymic development, as well as in the induction of mature responses. Activation of T cells will be dependent on unfolding, reduction and chain cleavage of the antigen, and the vagaries of competition with other determinants as well as hindrance in access to the major histocompatibility complex (MHC) or subsequently of the MHC/peptide complex to the T cell receptor. We here focus on a description of the parameters that determine the generation and display of determinants on MHC class II molecules by different types of antigen presenting cells in different locations. |
| doi_str_mv | 10.1016/S0198-8859(97)00079-7 |
| format | Article |
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We here focus on a description of the parameters that determine the generation and display of determinants on MHC class II molecules by different types of antigen presenting cells in different locations.</description><subject>Antigen Presentation</subject><subject>Antigens - immunology</subject><subject>Antigens - metabolism</subject><subject>Dendritic Cells - immunology</subject><subject>Endopeptidases - metabolism</subject><subject>Epithelial Cells</subject><subject>Epithelium - immunology</subject><subject>Histocompatibility Antigens Class II - immunology</subject><subject>Humans</subject><subject>Major Histocompatibility Complex - immunology</subject><subject>Peptides - immunology</subject><subject>T-Lymphocytes - immunology</subject><subject>Thymus Gland - cytology</subject><subject>Thymus Gland - immunology</subject><issn>0198-8859</issn><issn>1879-1166</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1997</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkMtKAzEUhoMotVYfodCV1MVoMpdcVjLUKxQsqOuQSU5KpDNTk2nBtzfTlm67ykn-7-QcPoTGBN8TTOjDJyaCJ5wXYirYHcaYiYSdoSHhsSCE0nM0PCKX6CqEnx7CLB-ggUgFK7JsiKZl07klNJOFbzWE4Jrl5MlZCx6aeJ-UdRtfysXsGl1YtQpwczhH6Pvl-Wv2lsw_Xt9n5TzReYq7JNM0V7lhJsdZbkzBsI77WFERU3CaVxUoCzGqhNI0rZjSSkBhrE6BpYLybIRu9_-uffu7gdDJ2gUNq5VqoN0EyUTKOCXZSZDQKAEXPVjsQe3bEDxYufauVv5PEix7lXKnUvaepGByp1Ky2Dc-DNhUNZhj18FdzB_3OUQdWwdeBu16a8Z50J00rTsx4R8vyoHx</recordid><startdate>19970501</startdate><enddate>19970501</enddate><creator>Schneider, S.C.</creator><creator>Sercarz, E.E.</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>H94</scope><scope>7X8</scope></search><sort><creationdate>19970501</creationdate><title>Antigen Processing Differences Among APC</title><author>Schneider, S.C. ; Sercarz, E.E.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c420t-3c64a4d7d4034dd570c879f9b1d5864bbeafe034b9ac62b7aca9e5dfc2e729683</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1997</creationdate><topic>Antigen Presentation</topic><topic>Antigens - immunology</topic><topic>Antigens - metabolism</topic><topic>Dendritic Cells - immunology</topic><topic>Endopeptidases - metabolism</topic><topic>Epithelial Cells</topic><topic>Epithelium - immunology</topic><topic>Histocompatibility Antigens Class II - immunology</topic><topic>Humans</topic><topic>Major Histocompatibility Complex - immunology</topic><topic>Peptides - immunology</topic><topic>T-Lymphocytes - immunology</topic><topic>Thymus Gland - cytology</topic><topic>Thymus Gland - immunology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Schneider, S.C.</creatorcontrib><creatorcontrib>Sercarz, E.E.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Human Immunology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Schneider, S.C.</au><au>Sercarz, E.E.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Antigen Processing Differences Among APC</atitle><jtitle>Human Immunology</jtitle><addtitle>Hum Immunol</addtitle><date>1997-05-01</date><risdate>1997</risdate><volume>54</volume><issue>2</issue><spage>148</spage><epage>158</epage><pages>148-158</pages><issn>0198-8859</issn><eissn>1879-1166</eissn><abstract>The hierarchy of display of determinants on a protein antigen is of critical importance with respect to which T cells will be selected during thymic development, as well as in the induction of mature responses. 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| fulltext | fulltext |
| identifier | ISSN: 0198-8859 |
| ispartof | Human Immunology, 1997-05, Vol.54 (2), p.148-158 |
| issn | 0198-8859 1879-1166 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_79278613 |
| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Antigen Presentation Antigens - immunology Antigens - metabolism Dendritic Cells - immunology Endopeptidases - metabolism Epithelial Cells Epithelium - immunology Histocompatibility Antigens Class II - immunology Humans Major Histocompatibility Complex - immunology Peptides - immunology T-Lymphocytes - immunology Thymus Gland - cytology Thymus Gland - immunology |
| title | Antigen Processing Differences Among APC |
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