Synthesis and antimicrobial testing of thiazolinyl-, thiazolidinonyl-quinoxalines and 1,2,4-triazolo[4,3-a]quinoxalines
Three novel series of quinoxaline derivatives namely 1-substituted amino-4-phenyl-1,2,4-triazolo[4,3-a]quinoxalines 3a-c, 2-[3,4,5-trisubstituted-2,3-dihydrothiazol-2-ylidene) hydrazono]-3-phenylquinoxalines 4a-j, 5a-e, and 2-[(3-substituted-4-oxothiazolidin-2-ylidene) hydrazone]-3-phenylquinoxaline...
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| Veröffentlicht in: | Pharmazie 1997-08, Vol.52 (8), p.594-598 |
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| creator | HABIB, N. S EL-HAWASH, S. A |
| description | Three novel series of quinoxaline derivatives namely 1-substituted amino-4-phenyl-1,2,4-triazolo[4,3-a]quinoxalines 3a-c, 2-[3,4,5-trisubstituted-2,3-dihydrothiazol-2-ylidene) hydrazono]-3-phenylquinoxalines 4a-j, 5a-e, and 2-[(3-substituted-4-oxothiazolidin-2-ylidene) hydrazone]-3-phenylquinoxalines 6a-e have been synthesized by cyclization of the key intermediates 2-substituted thiocarbamoylhydrazino-3-phenylquinoxalines 2a-e. The prepared compounds were tested in vitro for their antimicrobial activity. |
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S ; EL-HAWASH, S. A</creator><creatorcontrib>HABIB, N. S ; EL-HAWASH, S. A</creatorcontrib><description>Three novel series of quinoxaline derivatives namely 1-substituted amino-4-phenyl-1,2,4-triazolo[4,3-a]quinoxalines 3a-c, 2-[3,4,5-trisubstituted-2,3-dihydrothiazol-2-ylidene) hydrazono]-3-phenylquinoxalines 4a-j, 5a-e, and 2-[(3-substituted-4-oxothiazolidin-2-ylidene) hydrazone]-3-phenylquinoxalines 6a-e have been synthesized by cyclization of the key intermediates 2-substituted thiocarbamoylhydrazino-3-phenylquinoxalines 2a-e. The prepared compounds were tested in vitro for their antimicrobial activity.</description><identifier>ISSN: 0031-7144</identifier><identifier>PMID: 9292917</identifier><identifier>CODEN: PHARAT</identifier><language>eng</language><publisher>Eschborn: Govi</publisher><subject>Anti-Bacterial Agents ; Anti-Infective Agents - chemical synthesis ; Anti-Infective Agents - pharmacology ; Antibacterial agents ; Antibiotics. Antiinfectious agents. 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A</creatorcontrib><title>Synthesis and antimicrobial testing of thiazolinyl-, thiazolidinonyl-quinoxalines and 1,2,4-triazolo[4,3-a]quinoxalines</title><title>Pharmazie</title><addtitle>Pharmazie</addtitle><description>Three novel series of quinoxaline derivatives namely 1-substituted amino-4-phenyl-1,2,4-triazolo[4,3-a]quinoxalines 3a-c, 2-[3,4,5-trisubstituted-2,3-dihydrothiazol-2-ylidene) hydrazono]-3-phenylquinoxalines 4a-j, 5a-e, and 2-[(3-substituted-4-oxothiazolidin-2-ylidene) hydrazone]-3-phenylquinoxalines 6a-e have been synthesized by cyclization of the key intermediates 2-substituted thiocarbamoylhydrazino-3-phenylquinoxalines 2a-e. The prepared compounds were tested in vitro for their antimicrobial activity.</description><subject>Anti-Bacterial Agents</subject><subject>Anti-Infective Agents - chemical synthesis</subject><subject>Anti-Infective Agents - pharmacology</subject><subject>Antibacterial agents</subject><subject>Antibiotics. Antiinfectious agents. Antiparasitic agents</subject><subject>Biological and medical sciences</subject><subject>Candida albicans - drug effects</subject><subject>Escherichia coli - drug effects</subject><subject>Medical sciences</subject><subject>Microbial Sensitivity Tests</subject><subject>Pharmacology. Drug treatments</subject><subject>Quinoxalines - chemical synthesis</subject><subject>Quinoxalines - pharmacology</subject><subject>Staphylococcus aureus - drug effects</subject><subject>Thiazoles - chemical synthesis</subject><subject>Thiazoles - pharmacology</subject><subject>Triazoles - chemical synthesis</subject><subject>Triazoles - pharmacology</subject><issn>0031-7144</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1997</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpNkE1LxDAQhnNQ1nX1Jwg9iKcG8tWkPcriFyx4UE8iZbZJ3Ujb7DYpWn-90S2LDMN8vA8vzByhOSGcYkWFOEGn3n8QwiST-QzNChaDqjn6fBq7sDHe-gQ6HTPY1la9W1tokmB8sN174uokbCx8u8Z2Y4PTw6Rt5343uyE2XxBls_ehKUsFDv0f5l5FyjG8_afO0HENjTfnU12gl9ub5-U9Xj3ePSyvV3jLeBYw1ZppAzIrqKwBpJIsA1AkE0rldUWp4oVSSrCc0XVeS6gEB13lIqfMmIzwBbra-257txviPWVrfWWaBjrjBl-qgkUnQSN4MYHDujW63Pa2hX4sp09F_XLSwVfQ1D10lfUHjCkpJSP8B7fGcgA</recordid><startdate>19970801</startdate><enddate>19970801</enddate><creator>HABIB, N. 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Antiparasitic agents</topic><topic>Biological and medical sciences</topic><topic>Candida albicans - drug effects</topic><topic>Escherichia coli - drug effects</topic><topic>Medical sciences</topic><topic>Microbial Sensitivity Tests</topic><topic>Pharmacology. Drug treatments</topic><topic>Quinoxalines - chemical synthesis</topic><topic>Quinoxalines - pharmacology</topic><topic>Staphylococcus aureus - drug effects</topic><topic>Thiazoles - chemical synthesis</topic><topic>Thiazoles - pharmacology</topic><topic>Triazoles - chemical synthesis</topic><topic>Triazoles - pharmacology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>HABIB, N. S</creatorcontrib><creatorcontrib>EL-HAWASH, S. 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A</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Synthesis and antimicrobial testing of thiazolinyl-, thiazolidinonyl-quinoxalines and 1,2,4-triazolo[4,3-a]quinoxalines</atitle><jtitle>Pharmazie</jtitle><addtitle>Pharmazie</addtitle><date>1997-08-01</date><risdate>1997</risdate><volume>52</volume><issue>8</issue><spage>594</spage><epage>598</epage><pages>594-598</pages><issn>0031-7144</issn><coden>PHARAT</coden><abstract>Three novel series of quinoxaline derivatives namely 1-substituted amino-4-phenyl-1,2,4-triazolo[4,3-a]quinoxalines 3a-c, 2-[3,4,5-trisubstituted-2,3-dihydrothiazol-2-ylidene) hydrazono]-3-phenylquinoxalines 4a-j, 5a-e, and 2-[(3-substituted-4-oxothiazolidin-2-ylidene) hydrazone]-3-phenylquinoxalines 6a-e have been synthesized by cyclization of the key intermediates 2-substituted thiocarbamoylhydrazino-3-phenylquinoxalines 2a-e. The prepared compounds were tested in vitro for their antimicrobial activity.</abstract><cop>Eschborn</cop><pub>Govi</pub><pmid>9292917</pmid><tpages>5</tpages></addata></record> |
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| ispartof | Pharmazie, 1997-08, Vol.52 (8), p.594-598 |
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| source | MEDLINE; EZB-FREE-00999 freely available EZB journals |
| subjects | Anti-Bacterial Agents Anti-Infective Agents - chemical synthesis Anti-Infective Agents - pharmacology Antibacterial agents Antibiotics. Antiinfectious agents. Antiparasitic agents Biological and medical sciences Candida albicans - drug effects Escherichia coli - drug effects Medical sciences Microbial Sensitivity Tests Pharmacology. Drug treatments Quinoxalines - chemical synthesis Quinoxalines - pharmacology Staphylococcus aureus - drug effects Thiazoles - chemical synthesis Thiazoles - pharmacology Triazoles - chemical synthesis Triazoles - pharmacology |
| title | Synthesis and antimicrobial testing of thiazolinyl-, thiazolidinonyl-quinoxalines and 1,2,4-triazolo[4,3-a]quinoxalines |
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