Synthesis and antimicrobial testing of thiazolinyl-, thiazolidinonyl-quinoxalines and 1,2,4-triazolo[4,3-a]quinoxalines

Three novel series of quinoxaline derivatives namely 1-substituted amino-4-phenyl-1,2,4-triazolo[4,3-a]quinoxalines 3a-c, 2-[3,4,5-trisubstituted-2,3-dihydrothiazol-2-ylidene) hydrazono]-3-phenylquinoxalines 4a-j, 5a-e, and 2-[(3-substituted-4-oxothiazolidin-2-ylidene) hydrazone]-3-phenylquinoxaline...

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Veröffentlicht in:	Pharmazie 1997-08, Vol.52 (8), p.594-598
Hauptverfasser:	HABIB, N. S, EL-HAWASH, S. A
Format:	Artikel
Sprache:	eng
Schlagworte:	Anti-Bacterial Agents Anti-Infective Agents - chemical synthesis Anti-Infective Agents - pharmacology Antibacterial agents Antibiotics. Antiinfectious agents. Antiparasitic agents Biological and medical sciences Candida albicans - drug effects Escherichia coli - drug effects Medical sciences Microbial Sensitivity Tests Pharmacology. Drug treatments Quinoxalines - chemical synthesis Quinoxalines - pharmacology Staphylococcus aureus - drug effects Thiazoles - chemical synthesis Thiazoles - pharmacology Triazoles - chemical synthesis Triazoles - pharmacology
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Zusammenfassung:	Three novel series of quinoxaline derivatives namely 1-substituted amino-4-phenyl-1,2,4-triazolo[4,3-a]quinoxalines 3a-c, 2-[3,4,5-trisubstituted-2,3-dihydrothiazol-2-ylidene) hydrazono]-3-phenylquinoxalines 4a-j, 5a-e, and 2-[(3-substituted-4-oxothiazolidin-2-ylidene) hydrazone]-3-phenylquinoxalines 6a-e have been synthesized by cyclization of the key intermediates 2-substituted thiocarbamoylhydrazino-3-phenylquinoxalines 2a-e. The prepared compounds were tested in vitro for their antimicrobial activity.
ISSN:	0031-7144