In vitro experimental studies of sialyl Lewis x and sialyl Lewis a on endothelial and carcinoma cells: crucial glycans on selectin ligands
Extravasation from the blood of malignant tumour cells that form metastasis and leukocytes that go into tissues require contact between selectins and their sialyl Lewis x and sialyl Lewis a (sLe(x) and sLe(a) respectively) decorated ligands. Endothelial cells have been shown to express sLe(x) epitop...
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| Veröffentlicht in: | Glycoconjugate journal 1997-08, Vol.14 (5), p.593-600 |
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| container_issue | 5 |
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| container_title | Glycoconjugate journal |
| container_volume | 14 |
| creator | Renkonen, R Mattila, P Majuri, M L Räbinä, J Toppila, S Renkonen, J Hirvas, L Niittymäki, J Turunen, J P Renkonen, O Paavonen, T |
| description | Extravasation from the blood of malignant tumour cells that form metastasis and leukocytes that go into tissues require contact between selectins and their sialyl Lewis x and sialyl Lewis a (sLe(x) and sLe(a) respectively) decorated ligands. Endothelial cells have been shown to express sLe(x) epitopes in lymph nodes and at sites of inflammation, and this is crucial for the selectin-dependent leukocyte traffic. Besides the ability to synthesize sLe(x) on sialylated N-acetyllactosamine via the action of alpha(1,3)fucosyltransferase(s), endothelial cells can also degrade sLe(x) to Lewis x through the action of alpha(2,3)sialidase(s). In addition, several epithelial tumors possess the machinery to synthesize sLe(x), which facilitates their adhesion to endothelial E- and P-selectin. |
| doi_str_mv | 10.1023/a:1018536509950 |
| format | Article |
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| identifier | ISSN: 0282-0080 |
| ispartof | Glycoconjugate journal, 1997-08, Vol.14 (5), p.593-600 |
| issn | 0282-0080 1573-4986 |
| language | eng |
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| source | MEDLINE; Springer Nature - Complete Springer Journals |
| subjects | Animals Carbohydrate Conformation Carbohydrate Sequence Endothelium, Vascular - physiology Fucosyltransferases - metabolism Humans Inflammation - physiopathology Lymph Nodes - physiopathology Molecular Sequence Data Neoplasms - physiopathology Neuraminidase - metabolism Oligosaccharides - biosynthesis Oligosaccharides - chemistry Tumors |
| title | In vitro experimental studies of sialyl Lewis x and sialyl Lewis a on endothelial and carcinoma cells: crucial glycans on selectin ligands |
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