Increased acylphosphatase levels in erythrocytes from hyperthyroid patients
Acylphosphatase activity and content were measured in erythrocytes from hyperthyroid patients and healthy controls. In addition, the soluble enzymes glucose-6-phosphate dehydrogenase, hexokinase, and the membrane bound (Na + + K +)-ATPase and Ca 2+-ATPase were assayed. Our results confirmed previous...
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| Veröffentlicht in: | Clinica chimica acta 1989-08, Vol.183 (3), p.351-358 |
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| container_title | Clinica chimica acta |
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| creator | Nassi, Paolo Liguri, Gianfranco Nediani, Chiara Taddei, Niccoló Piccinni, Patrizia Degl'Innocenti, Donatella Gheri, Riccardo G. Ramponi, Giampietro |
| description | Acylphosphatase activity and content were measured in erythrocytes from hyperthyroid patients and healthy controls. In addition, the soluble enzymes glucose-6-phosphate dehydrogenase, hexokinase, and the membrane bound (Na
+ + K
+)-ATPase and Ca
2+-ATPase were assayed. Our results confirmed previous studies indicating a decrease of (Na
++ K
+)-ATPase and an increase of Ca
2+-ATPase activity in hyperthyroid erythrocytes. While glucose-6-phosphate dehydrogenase was not significantly changed, hexokinase and acylphosphatase activities were significantly higher in the hyperthyroid group. Both activities and content of acylphosphatase returned to normal levels in erythrocytes from treated patients, when they were euthyroid. These findings suggest that an excess of thyroid hormones may stimulate acylphosphatase biosynthesis in erythroid cells and indicate a potential clinical usefulness of this enzyme in hyperthyroidism. |
| doi_str_mv | 10.1016/0009-8981(89)90370-7 |
| format | Article |
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+ + K
+)-ATPase and Ca
2+-ATPase were assayed. Our results confirmed previous studies indicating a decrease of (Na
++ K
+)-ATPase and an increase of Ca
2+-ATPase activity in hyperthyroid erythrocytes. While glucose-6-phosphate dehydrogenase was not significantly changed, hexokinase and acylphosphatase activities were significantly higher in the hyperthyroid group. Both activities and content of acylphosphatase returned to normal levels in erythrocytes from treated patients, when they were euthyroid. These findings suggest that an excess of thyroid hormones may stimulate acylphosphatase biosynthesis in erythroid cells and indicate a potential clinical usefulness of this enzyme in hyperthyroidism.</description><identifier>ISSN: 0009-8981</identifier><identifier>EISSN: 1873-3492</identifier><identifier>DOI: 10.1016/0009-8981(89)90370-7</identifier><identifier>PMID: 2553305</identifier><identifier>CODEN: CCATAR</identifier><language>eng</language><publisher>Shannon: Elsevier B.V</publisher><subject>Acid Anhydride Hydrolases ; Acylphosphatase ; Acylphosphatase level ; Adenosine Triphosphatases - blood ; Adult ; Analytical, structural and metabolic biochemistry ; Biological and medical sciences ; Enzymes and enzyme inhibitors ; Erythrocyte Membrane - enzymology ; Erythrocytes - drug effects ; Erythrocytes - enzymology ; Female ; Fundamental and applied biological sciences. Psychology ; Glucosephosphate Dehydrogenase - metabolism ; Hexokinase - metabolism ; Human erythrocytes ; Humans ; Hydrolases ; Hyperthyroidism ; Hyperthyroidism - drug therapy ; Hyperthyroidism - enzymology ; Male ; Methimazole - pharmacology ; Methimazole - therapeutic use ; Middle Aged ; Phosphoric Monoester Hydrolases - blood ; Thyrotropin - blood ; Thyroxine - blood ; Triiodothyronine - blood</subject><ispartof>Clinica chimica acta, 1989-08, Vol.183 (3), p.351-358</ispartof><rights>1989</rights><rights>1990 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c386t-a8c46c2683cab50f4ad6e2d26a4d84ac20d100ebbab9ac15adfa6d3b44fcc2513</citedby><cites>FETCH-LOGICAL-c386t-a8c46c2683cab50f4ad6e2d26a4d84ac20d100ebbab9ac15adfa6d3b44fcc2513</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/0009898189903707$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=6959522$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/2553305$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Nassi, Paolo</creatorcontrib><creatorcontrib>Liguri, Gianfranco</creatorcontrib><creatorcontrib>Nediani, Chiara</creatorcontrib><creatorcontrib>Taddei, Niccoló</creatorcontrib><creatorcontrib>Piccinni, Patrizia</creatorcontrib><creatorcontrib>Degl'Innocenti, Donatella</creatorcontrib><creatorcontrib>Gheri, Riccardo G.</creatorcontrib><creatorcontrib>Ramponi, Giampietro</creatorcontrib><title>Increased acylphosphatase levels in erythrocytes from hyperthyroid patients</title><title>Clinica chimica acta</title><addtitle>Clin Chim Acta</addtitle><description>Acylphosphatase activity and content were measured in erythrocytes from hyperthyroid patients and healthy controls. In addition, the soluble enzymes glucose-6-phosphate dehydrogenase, hexokinase, and the membrane bound (Na
+ + K
+)-ATPase and Ca
2+-ATPase were assayed. Our results confirmed previous studies indicating a decrease of (Na
++ K
+)-ATPase and an increase of Ca
2+-ATPase activity in hyperthyroid erythrocytes. While glucose-6-phosphate dehydrogenase was not significantly changed, hexokinase and acylphosphatase activities were significantly higher in the hyperthyroid group. Both activities and content of acylphosphatase returned to normal levels in erythrocytes from treated patients, when they were euthyroid. These findings suggest that an excess of thyroid hormones may stimulate acylphosphatase biosynthesis in erythroid cells and indicate a potential clinical usefulness of this enzyme in hyperthyroidism.</description><subject>Acid Anhydride Hydrolases</subject><subject>Acylphosphatase</subject><subject>Acylphosphatase level</subject><subject>Adenosine Triphosphatases - blood</subject><subject>Adult</subject><subject>Analytical, structural and metabolic biochemistry</subject><subject>Biological and medical sciences</subject><subject>Enzymes and enzyme inhibitors</subject><subject>Erythrocyte Membrane - enzymology</subject><subject>Erythrocytes - drug effects</subject><subject>Erythrocytes - enzymology</subject><subject>Female</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Glucosephosphate Dehydrogenase - metabolism</subject><subject>Hexokinase - metabolism</subject><subject>Human erythrocytes</subject><subject>Humans</subject><subject>Hydrolases</subject><subject>Hyperthyroidism</subject><subject>Hyperthyroidism - drug therapy</subject><subject>Hyperthyroidism - enzymology</subject><subject>Male</subject><subject>Methimazole - pharmacology</subject><subject>Methimazole - therapeutic use</subject><subject>Middle Aged</subject><subject>Phosphoric Monoester Hydrolases - blood</subject><subject>Thyrotropin - blood</subject><subject>Thyroxine - blood</subject><subject>Triiodothyronine - blood</subject><issn>0009-8981</issn><issn>1873-3492</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1989</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kE2L1EAQQBtR1nH1HyjkIKKHaH-lk74Isrjr4oIXPTeV6gppySSxu2ch_94eZ5ijlyqq6lVRPMZeC_5RcGE-cc5t3dlOvO_sB8tVy-v2CduJrlW10lY-ZbsL8py9SOl3KTU34opdyaZRijc79v1-xkiQyFeA27SOS1pHyKVRTfRIU6rCXFHc8hgX3DKlaojLvhq3lWIet7gEX62QA805vWTPBpgSvTrna_br9uvPm2_1w4-7-5svDzWqzuQaOtQGpekUQt_wQYM3JL00oH2nASX3gnPqe-gtoGjAD2C86rUeEGUj1DV7d7q7xuXPgVJ2-5CQpglmWg7JtVa2rTCqgPoEYlxSijS4NYY9xM0J7o4O3VGQOwoqwf1z6Nqy9uZ8_9DvyV-WztLK_O15DglhGiLMGNIFM7axjZQF-3zCikV6DBRdwuIJyYdImJ1fwv__-AtY5Y-n</recordid><startdate>19890831</startdate><enddate>19890831</enddate><creator>Nassi, Paolo</creator><creator>Liguri, Gianfranco</creator><creator>Nediani, Chiara</creator><creator>Taddei, Niccoló</creator><creator>Piccinni, Patrizia</creator><creator>Degl'Innocenti, Donatella</creator><creator>Gheri, Riccardo G.</creator><creator>Ramponi, Giampietro</creator><general>Elsevier B.V</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19890831</creationdate><title>Increased acylphosphatase levels in erythrocytes from hyperthyroid patients</title><author>Nassi, Paolo ; Liguri, Gianfranco ; Nediani, Chiara ; Taddei, Niccoló ; Piccinni, Patrizia ; Degl'Innocenti, Donatella ; Gheri, Riccardo G. ; Ramponi, Giampietro</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c386t-a8c46c2683cab50f4ad6e2d26a4d84ac20d100ebbab9ac15adfa6d3b44fcc2513</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1989</creationdate><topic>Acid Anhydride Hydrolases</topic><topic>Acylphosphatase</topic><topic>Acylphosphatase level</topic><topic>Adenosine Triphosphatases - blood</topic><topic>Adult</topic><topic>Analytical, structural and metabolic biochemistry</topic><topic>Biological and medical sciences</topic><topic>Enzymes and enzyme inhibitors</topic><topic>Erythrocyte Membrane - enzymology</topic><topic>Erythrocytes - drug effects</topic><topic>Erythrocytes - enzymology</topic><topic>Female</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Glucosephosphate Dehydrogenase - metabolism</topic><topic>Hexokinase - metabolism</topic><topic>Human erythrocytes</topic><topic>Humans</topic><topic>Hydrolases</topic><topic>Hyperthyroidism</topic><topic>Hyperthyroidism - drug therapy</topic><topic>Hyperthyroidism - enzymology</topic><topic>Male</topic><topic>Methimazole - pharmacology</topic><topic>Methimazole - therapeutic use</topic><topic>Middle Aged</topic><topic>Phosphoric Monoester Hydrolases - blood</topic><topic>Thyrotropin - blood</topic><topic>Thyroxine - blood</topic><topic>Triiodothyronine - blood</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Nassi, Paolo</creatorcontrib><creatorcontrib>Liguri, Gianfranco</creatorcontrib><creatorcontrib>Nediani, Chiara</creatorcontrib><creatorcontrib>Taddei, Niccoló</creatorcontrib><creatorcontrib>Piccinni, Patrizia</creatorcontrib><creatorcontrib>Degl'Innocenti, Donatella</creatorcontrib><creatorcontrib>Gheri, Riccardo G.</creatorcontrib><creatorcontrib>Ramponi, Giampietro</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Clinica chimica acta</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Nassi, Paolo</au><au>Liguri, Gianfranco</au><au>Nediani, Chiara</au><au>Taddei, Niccoló</au><au>Piccinni, Patrizia</au><au>Degl'Innocenti, Donatella</au><au>Gheri, Riccardo G.</au><au>Ramponi, Giampietro</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Increased acylphosphatase levels in erythrocytes from hyperthyroid patients</atitle><jtitle>Clinica chimica acta</jtitle><addtitle>Clin Chim Acta</addtitle><date>1989-08-31</date><risdate>1989</risdate><volume>183</volume><issue>3</issue><spage>351</spage><epage>358</epage><pages>351-358</pages><issn>0009-8981</issn><eissn>1873-3492</eissn><coden>CCATAR</coden><abstract>Acylphosphatase activity and content were measured in erythrocytes from hyperthyroid patients and healthy controls. In addition, the soluble enzymes glucose-6-phosphate dehydrogenase, hexokinase, and the membrane bound (Na
+ + K
+)-ATPase and Ca
2+-ATPase were assayed. Our results confirmed previous studies indicating a decrease of (Na
++ K
+)-ATPase and an increase of Ca
2+-ATPase activity in hyperthyroid erythrocytes. While glucose-6-phosphate dehydrogenase was not significantly changed, hexokinase and acylphosphatase activities were significantly higher in the hyperthyroid group. Both activities and content of acylphosphatase returned to normal levels in erythrocytes from treated patients, when they were euthyroid. These findings suggest that an excess of thyroid hormones may stimulate acylphosphatase biosynthesis in erythroid cells and indicate a potential clinical usefulness of this enzyme in hyperthyroidism.</abstract><cop>Shannon</cop><pub>Elsevier B.V</pub><pmid>2553305</pmid><doi>10.1016/0009-8981(89)90370-7</doi><tpages>8</tpages></addata></record> |
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| ispartof | Clinica chimica acta, 1989-08, Vol.183 (3), p.351-358 |
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| subjects | Acid Anhydride Hydrolases Acylphosphatase Acylphosphatase level Adenosine Triphosphatases - blood Adult Analytical, structural and metabolic biochemistry Biological and medical sciences Enzymes and enzyme inhibitors Erythrocyte Membrane - enzymology Erythrocytes - drug effects Erythrocytes - enzymology Female Fundamental and applied biological sciences. Psychology Glucosephosphate Dehydrogenase - metabolism Hexokinase - metabolism Human erythrocytes Humans Hydrolases Hyperthyroidism Hyperthyroidism - drug therapy Hyperthyroidism - enzymology Male Methimazole - pharmacology Methimazole - therapeutic use Middle Aged Phosphoric Monoester Hydrolases - blood Thyrotropin - blood Thyroxine - blood Triiodothyronine - blood |
| title | Increased acylphosphatase levels in erythrocytes from hyperthyroid patients |
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