Factors influencing local recurrence after excision and radiotherapy for primary breast cancer
Between November 1979 and December 1986, 263 patients were treated for primary breast cancer by local excision and radiotherapy at the City Hospital, Nottingham. Local recurrence within the treated breast occurred in 56 patients (21 per cent), in 18 (6·8 per cent) of whom it was gross and uncontroll...
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| Veröffentlicht in: | British journal of surgery 1989-09, Vol.76 (9), p.890-894 |
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| container_title | British journal of surgery |
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| creator | Locker, A. P. Ellis, I. O. Morgan, D. A. L. Elston, C. W. Mitchell, A. Blamey, R. W. |
| description | Between November 1979 and December 1986, 263 patients were treated for primary breast cancer by local excision and radiotherapy at the City Hospital, Nottingham. Local recurrence within the treated breast occurred in 56 patients (21 per cent), in 18 (6·8 per cent) of whom it was gross and uncontrollable. An analysis of clinicopathological features shows patient age, nodal status, tumour size, presence of definitive vascular invasion, adjacent ductal carcinoma in situ and grade to be predictive of local recurrence. A Cox's multivariate analysis of these factors shows the first four to be independently significant. The factors can be combined as a prognostic index which allows identification of patients at high risk of local recurrence. On the basis of these findings we have altered our selection policy for patients suitable for breast conservation. |
| doi_str_mv | 10.1002/bjs.1800760906 |
| format | Article |
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P. ; Ellis, I. O. ; Morgan, D. A. L. ; Elston, C. W. ; Mitchell, A. ; Blamey, R. W.</creator><creatorcontrib>Locker, A. P. ; Ellis, I. O. ; Morgan, D. A. L. ; Elston, C. W. ; Mitchell, A. ; Blamey, R. W.</creatorcontrib><description>Between November 1979 and December 1986, 263 patients were treated for primary breast cancer by local excision and radiotherapy at the City Hospital, Nottingham. Local recurrence within the treated breast occurred in 56 patients (21 per cent), in 18 (6·8 per cent) of whom it was gross and uncontrollable. An analysis of clinicopathological features shows patient age, nodal status, tumour size, presence of definitive vascular invasion, adjacent ductal carcinoma in situ and grade to be predictive of local recurrence. A Cox's multivariate analysis of these factors shows the first four to be independently significant. The factors can be combined as a prognostic index which allows identification of patients at high risk of local recurrence. On the basis of these findings we have altered our selection policy for patients suitable for breast conservation.</description><identifier>ISSN: 0007-1323</identifier><identifier>EISSN: 1365-2168</identifier><identifier>DOI: 10.1002/bjs.1800760906</identifier><identifier>PMID: 2553196</identifier><identifier>CODEN: BJSUAM</identifier><language>eng</language><publisher>Bristol: John Wiley & Sons, Ltd</publisher><subject>Adult ; Age Factors ; Aged ; Biological and medical sciences ; Breast cancer ; breast conservation ; Breast Neoplasms - pathology ; Breast Neoplasms - radiotherapy ; Breast Neoplasms - therapy ; Carcinoma in Situ - pathology ; Carcinoma in Situ - therapy ; Carcinoma, Intraductal, Noninfiltrating - pathology ; Carcinoma, Intraductal, Noninfiltrating - therapy ; Combined Modality Therapy ; Follow-Up Studies ; Gynecology. Andrology. Obstetrics ; Humans ; Lymphatic Metastasis ; Mammary gland diseases ; Mastectomy, Segmental ; Medical sciences ; Middle Aged ; Neoplasm Recurrence, Local ; Probability ; Prognosis ; radiotherapy ; recurrence ; Tumors</subject><ispartof>British journal of surgery, 1989-09, Vol.76 (9), p.890-894</ispartof><rights>Copyright © 1989 British Journal of Surgery Society Ltd.</rights><rights>1990 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4636-f990045672666422cad10bace43a2e98c53fd334e159783522b4c8e11a06d2683</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fbjs.1800760906$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fbjs.1800760906$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27903,27904,45553,45554</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=6785698$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/2553196$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Locker, A. P.</creatorcontrib><creatorcontrib>Ellis, I. O.</creatorcontrib><creatorcontrib>Morgan, D. A. L.</creatorcontrib><creatorcontrib>Elston, C. W.</creatorcontrib><creatorcontrib>Mitchell, A.</creatorcontrib><creatorcontrib>Blamey, R. W.</creatorcontrib><title>Factors influencing local recurrence after excision and radiotherapy for primary breast cancer</title><title>British journal of surgery</title><addtitle>Br J Surg</addtitle><description>Between November 1979 and December 1986, 263 patients were treated for primary breast cancer by local excision and radiotherapy at the City Hospital, Nottingham. Local recurrence within the treated breast occurred in 56 patients (21 per cent), in 18 (6·8 per cent) of whom it was gross and uncontrollable. An analysis of clinicopathological features shows patient age, nodal status, tumour size, presence of definitive vascular invasion, adjacent ductal carcinoma in situ and grade to be predictive of local recurrence. A Cox's multivariate analysis of these factors shows the first four to be independently significant. The factors can be combined as a prognostic index which allows identification of patients at high risk of local recurrence. On the basis of these findings we have altered our selection policy for patients suitable for breast conservation.</description><subject>Adult</subject><subject>Age Factors</subject><subject>Aged</subject><subject>Biological and medical sciences</subject><subject>Breast cancer</subject><subject>breast conservation</subject><subject>Breast Neoplasms - pathology</subject><subject>Breast Neoplasms - radiotherapy</subject><subject>Breast Neoplasms - therapy</subject><subject>Carcinoma in Situ - pathology</subject><subject>Carcinoma in Situ - therapy</subject><subject>Carcinoma, Intraductal, Noninfiltrating - pathology</subject><subject>Carcinoma, Intraductal, Noninfiltrating - therapy</subject><subject>Combined Modality Therapy</subject><subject>Follow-Up Studies</subject><subject>Gynecology. Andrology. Obstetrics</subject><subject>Humans</subject><subject>Lymphatic Metastasis</subject><subject>Mammary gland diseases</subject><subject>Mastectomy, Segmental</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Neoplasm Recurrence, Local</subject><subject>Probability</subject><subject>Prognosis</subject><subject>radiotherapy</subject><subject>recurrence</subject><subject>Tumors</subject><issn>0007-1323</issn><issn>1365-2168</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1989</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFUU1P3DAQtSoqumx77Q3JB9RbqD9iJz7CqgtUqyJUUG-1Js6EGrLJYieC_fc12mj3NJp5783XI-QrZ-ecMfG9eornvGSs0Mww_YHMuNQqE1yXR2TGUj3jUshP5CTGJ8a4ZEock2OhlORGz8jfJbihD5H6rmlH7JzvHmnbO2hpQDeGkEpIoRkwUHxzPvq-o9DVNEDt--EfBthsadMHugl-DWFLq4AQB-ogCcNn8rGBNuKXKc7Jw_LH_eI6W91e3SwuVpnLtdRZYwxjudKF0FrnQjioOavAYS5BoCmdkk0tZY5cmaKUSogqdyVyDkzXQpdyTr7t-m5C_zJiHOzaR4dtCx32Y7SFEUXBNU_E04k4Vmus7bS1nR6S8LMJh5ie0IR0ho97mi5Kpc37PLOjvfoWt3uYM_tuik2m2IMp9vLn70OWtNlO6-OAb3sthOfUXhbK_vl1ZY1YyYW6u7S5_A-Fro7O</recordid><startdate>198909</startdate><enddate>198909</enddate><creator>Locker, A. P.</creator><creator>Ellis, I. O.</creator><creator>Morgan, D. A. L.</creator><creator>Elston, C. W.</creator><creator>Mitchell, A.</creator><creator>Blamey, R. W.</creator><general>John Wiley & Sons, Ltd</general><general>Wiley</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>198909</creationdate><title>Factors influencing local recurrence after excision and radiotherapy for primary breast cancer</title><author>Locker, A. P. ; Ellis, I. O. ; Morgan, D. A. L. ; Elston, C. W. ; Mitchell, A. ; Blamey, R. W.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4636-f990045672666422cad10bace43a2e98c53fd334e159783522b4c8e11a06d2683</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1989</creationdate><topic>Adult</topic><topic>Age Factors</topic><topic>Aged</topic><topic>Biological and medical sciences</topic><topic>Breast cancer</topic><topic>breast conservation</topic><topic>Breast Neoplasms - pathology</topic><topic>Breast Neoplasms - radiotherapy</topic><topic>Breast Neoplasms - therapy</topic><topic>Carcinoma in Situ - pathology</topic><topic>Carcinoma in Situ - therapy</topic><topic>Carcinoma, Intraductal, Noninfiltrating - pathology</topic><topic>Carcinoma, Intraductal, Noninfiltrating - therapy</topic><topic>Combined Modality Therapy</topic><topic>Follow-Up Studies</topic><topic>Gynecology. Andrology. Obstetrics</topic><topic>Humans</topic><topic>Lymphatic Metastasis</topic><topic>Mammary gland diseases</topic><topic>Mastectomy, Segmental</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Neoplasm Recurrence, Local</topic><topic>Probability</topic><topic>Prognosis</topic><topic>radiotherapy</topic><topic>recurrence</topic><topic>Tumors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Locker, A. P.</creatorcontrib><creatorcontrib>Ellis, I. O.</creatorcontrib><creatorcontrib>Morgan, D. A. L.</creatorcontrib><creatorcontrib>Elston, C. W.</creatorcontrib><creatorcontrib>Mitchell, A.</creatorcontrib><creatorcontrib>Blamey, R. 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W.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Factors influencing local recurrence after excision and radiotherapy for primary breast cancer</atitle><jtitle>British journal of surgery</jtitle><addtitle>Br J Surg</addtitle><date>1989-09</date><risdate>1989</risdate><volume>76</volume><issue>9</issue><spage>890</spage><epage>894</epage><pages>890-894</pages><issn>0007-1323</issn><eissn>1365-2168</eissn><coden>BJSUAM</coden><abstract>Between November 1979 and December 1986, 263 patients were treated for primary breast cancer by local excision and radiotherapy at the City Hospital, Nottingham. Local recurrence within the treated breast occurred in 56 patients (21 per cent), in 18 (6·8 per cent) of whom it was gross and uncontrollable. An analysis of clinicopathological features shows patient age, nodal status, tumour size, presence of definitive vascular invasion, adjacent ductal carcinoma in situ and grade to be predictive of local recurrence. A Cox's multivariate analysis of these factors shows the first four to be independently significant. The factors can be combined as a prognostic index which allows identification of patients at high risk of local recurrence. On the basis of these findings we have altered our selection policy for patients suitable for breast conservation.</abstract><cop>Bristol</cop><pub>John Wiley & Sons, Ltd</pub><pmid>2553196</pmid><doi>10.1002/bjs.1800760906</doi><tpages>5</tpages></addata></record> |
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| ispartof | British journal of surgery, 1989-09, Vol.76 (9), p.890-894 |
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| source | MEDLINE; Wiley Online Library Journals Frontfile Complete |
| subjects | Adult Age Factors Aged Biological and medical sciences Breast cancer breast conservation Breast Neoplasms - pathology Breast Neoplasms - radiotherapy Breast Neoplasms - therapy Carcinoma in Situ - pathology Carcinoma in Situ - therapy Carcinoma, Intraductal, Noninfiltrating - pathology Carcinoma, Intraductal, Noninfiltrating - therapy Combined Modality Therapy Follow-Up Studies Gynecology. Andrology. Obstetrics Humans Lymphatic Metastasis Mammary gland diseases Mastectomy, Segmental Medical sciences Middle Aged Neoplasm Recurrence, Local Probability Prognosis radiotherapy recurrence Tumors |
| title | Factors influencing local recurrence after excision and radiotherapy for primary breast cancer |
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