Differential distribution of BDNF and TRKB in regenerating dorsal column axons
DORSAL column axons can regenerate into peripheral nerve grafts. The neurotrophin BDNF and its receptor TrkB are synthesized in dorsal root ganglion neurons, and have been implicated in regeneration. The aim of this study was to examine the distribution of BDNF and TrkB in dorsal column axons which...
Gespeichert in:
| Veröffentlicht in: | Neuroreport 1997-08, Vol.8 (12), p.2655-2659 |
|---|---|
| 1. Verfasser: | |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 2659 |
|---|---|
| container_issue | 12 |
| container_start_page | 2655 |
| container_title | Neuroreport |
| container_volume | 8 |
| creator | Cameron, Adrian A |
| description | DORSAL column axons can regenerate into peripheral nerve grafts. The neurotrophin BDNF and its receptor TrkB are synthesized in dorsal root ganglion neurons, and have been implicated in regeneration. The aim of this study was to examine the distribution of BDNF and TrkB in dorsal column axons which regenerated into a peripheral nerve graft. BDNF-stained axons were found in all regions of the graft. BDNF was also expressed in small neurons in the superficial dorsal horn adjacent to the graft. TrkB was not found in any regenerating axons. Thus BDNF and TrkB are differentially expressed in regenerating dorsal column axons. In these axons BDNF may play a role that is independent of TrkB. |
| doi_str_mv | 10.1097/00001756-199708180-00004 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_79276765</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>79276765</sourcerecordid><originalsourceid>FETCH-LOGICAL-c4154-6834027d864800d42f22b75acaf9cc443d43010898829e6d6375b969fd9a50683</originalsourceid><addsrcrecordid>eNqFkUtPGzEUha0KRAPlJ1TyomI31J7xc0mggQoUpAokdpbjB7g4NrVnlPbfMyEhuwpvLJ3zHV_dYwAgRqcYSf4djQdzyhosJUcCC9SsJfIJTDDhXUOpeNgDEySpbIhk9DM4rPX3SEiExQE4kK2kozkB84vgvSsu9UFHaEPtS1gMfcgJZg-nF_MZ1MnCu1_XUxgSLO7RJVd0H9IjtLnUMWRyHJYJ6r851S9g3-tY3fH2PgL3sx9351fNze3lz_Ozm8YQTEnDREdQy61gRCBkSevbdsGpNtpLYwjpLOkQRkIK0UrHLOs4XUgmvZWaojF9BE42776U_GdwtVfLUI2LUSeXh6q4bDnjjH4IYkY6SsgaFBvQlFxrcV69lLDU5Z_CSK07V--dq13nbxIZo1-3M4bF0tldcFvy6H_b-roaHX3RyYS6w1qBOKfrncgGW-XYu1Kf47ByRT05Hfsn9b8f714BkKiWiw</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>16435445</pqid></control><display><type>article</type><title>Differential distribution of BDNF and TRKB in regenerating dorsal column axons</title><source>MEDLINE</source><source>Journals@Ovid Complete</source><creator>Cameron, Adrian A</creator><creatorcontrib>Cameron, Adrian A</creatorcontrib><description>DORSAL column axons can regenerate into peripheral nerve grafts. The neurotrophin BDNF and its receptor TrkB are synthesized in dorsal root ganglion neurons, and have been implicated in regeneration. The aim of this study was to examine the distribution of BDNF and TrkB in dorsal column axons which regenerated into a peripheral nerve graft. BDNF-stained axons were found in all regions of the graft. BDNF was also expressed in small neurons in the superficial dorsal horn adjacent to the graft. TrkB was not found in any regenerating axons. Thus BDNF and TrkB are differentially expressed in regenerating dorsal column axons. In these axons BDNF may play a role that is independent of TrkB.</description><identifier>ISSN: 0959-4965</identifier><identifier>EISSN: 1473-558X</identifier><identifier>DOI: 10.1097/00001756-199708180-00004</identifier><identifier>PMID: 9295095</identifier><language>eng</language><publisher>Hagerstown, MD: Lippincott-Raven Publishers</publisher><subject>Animals ; Axons - chemistry ; Axons - physiology ; Biochemistry and metabolism ; Biological and medical sciences ; Brain-Derived Neurotrophic Factor - analysis ; Central nervous system ; Female ; Fundamental and applied biological sciences. Psychology ; Immunohistochemistry ; Nerve Regeneration - physiology ; Nerve Tissue Proteins - analysis ; Peripheral Nerves - transplantation ; Rats ; Rats, Sprague-Dawley ; Receptor Protein-Tyrosine Kinases - analysis ; Receptor, Ciliary Neurotrophic Factor ; Receptors, Nerve Growth Factor - analysis ; Vertebrates: nervous system and sense organs</subject><ispartof>Neuroreport, 1997-08, Vol.8 (12), p.2655-2659</ispartof><rights>Lippincott-Raven Publishers.</rights><rights>1997 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4154-6834027d864800d42f22b75acaf9cc443d43010898829e6d6375b969fd9a50683</citedby><cites>FETCH-LOGICAL-c4154-6834027d864800d42f22b75acaf9cc443d43010898829e6d6375b969fd9a50683</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=2807758$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/9295095$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Cameron, Adrian A</creatorcontrib><title>Differential distribution of BDNF and TRKB in regenerating dorsal column axons</title><title>Neuroreport</title><addtitle>Neuroreport</addtitle><description>DORSAL column axons can regenerate into peripheral nerve grafts. The neurotrophin BDNF and its receptor TrkB are synthesized in dorsal root ganglion neurons, and have been implicated in regeneration. The aim of this study was to examine the distribution of BDNF and TrkB in dorsal column axons which regenerated into a peripheral nerve graft. BDNF-stained axons were found in all regions of the graft. BDNF was also expressed in small neurons in the superficial dorsal horn adjacent to the graft. TrkB was not found in any regenerating axons. Thus BDNF and TrkB are differentially expressed in regenerating dorsal column axons. In these axons BDNF may play a role that is independent of TrkB.</description><subject>Animals</subject><subject>Axons - chemistry</subject><subject>Axons - physiology</subject><subject>Biochemistry and metabolism</subject><subject>Biological and medical sciences</subject><subject>Brain-Derived Neurotrophic Factor - analysis</subject><subject>Central nervous system</subject><subject>Female</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Immunohistochemistry</subject><subject>Nerve Regeneration - physiology</subject><subject>Nerve Tissue Proteins - analysis</subject><subject>Peripheral Nerves - transplantation</subject><subject>Rats</subject><subject>Rats, Sprague-Dawley</subject><subject>Receptor Protein-Tyrosine Kinases - analysis</subject><subject>Receptor, Ciliary Neurotrophic Factor</subject><subject>Receptors, Nerve Growth Factor - analysis</subject><subject>Vertebrates: nervous system and sense organs</subject><issn>0959-4965</issn><issn>1473-558X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1997</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkUtPGzEUha0KRAPlJ1TyomI31J7xc0mggQoUpAokdpbjB7g4NrVnlPbfMyEhuwpvLJ3zHV_dYwAgRqcYSf4djQdzyhosJUcCC9SsJfIJTDDhXUOpeNgDEySpbIhk9DM4rPX3SEiExQE4kK2kozkB84vgvSsu9UFHaEPtS1gMfcgJZg-nF_MZ1MnCu1_XUxgSLO7RJVd0H9IjtLnUMWRyHJYJ6r851S9g3-tY3fH2PgL3sx9351fNze3lz_Ozm8YQTEnDREdQy61gRCBkSevbdsGpNtpLYwjpLOkQRkIK0UrHLOs4XUgmvZWaojF9BE42776U_GdwtVfLUI2LUSeXh6q4bDnjjH4IYkY6SsgaFBvQlFxrcV69lLDU5Z_CSK07V--dq13nbxIZo1-3M4bF0tldcFvy6H_b-roaHX3RyYS6w1qBOKfrncgGW-XYu1Kf47ByRT05Hfsn9b8f714BkKiWiw</recordid><startdate>19970818</startdate><enddate>19970818</enddate><creator>Cameron, Adrian A</creator><general>Lippincott-Raven Publishers</general><general>Lippincott Williams and Wilkins</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>7X8</scope></search><sort><creationdate>19970818</creationdate><title>Differential distribution of BDNF and TRKB in regenerating dorsal column axons</title><author>Cameron, Adrian A</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4154-6834027d864800d42f22b75acaf9cc443d43010898829e6d6375b969fd9a50683</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1997</creationdate><topic>Animals</topic><topic>Axons - chemistry</topic><topic>Axons - physiology</topic><topic>Biochemistry and metabolism</topic><topic>Biological and medical sciences</topic><topic>Brain-Derived Neurotrophic Factor - analysis</topic><topic>Central nervous system</topic><topic>Female</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Immunohistochemistry</topic><topic>Nerve Regeneration - physiology</topic><topic>Nerve Tissue Proteins - analysis</topic><topic>Peripheral Nerves - transplantation</topic><topic>Rats</topic><topic>Rats, Sprague-Dawley</topic><topic>Receptor Protein-Tyrosine Kinases - analysis</topic><topic>Receptor, Ciliary Neurotrophic Factor</topic><topic>Receptors, Nerve Growth Factor - analysis</topic><topic>Vertebrates: nervous system and sense organs</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Cameron, Adrian A</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Neuroreport</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Cameron, Adrian A</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Differential distribution of BDNF and TRKB in regenerating dorsal column axons</atitle><jtitle>Neuroreport</jtitle><addtitle>Neuroreport</addtitle><date>1997-08-18</date><risdate>1997</risdate><volume>8</volume><issue>12</issue><spage>2655</spage><epage>2659</epage><pages>2655-2659</pages><issn>0959-4965</issn><eissn>1473-558X</eissn><abstract>DORSAL column axons can regenerate into peripheral nerve grafts. The neurotrophin BDNF and its receptor TrkB are synthesized in dorsal root ganglion neurons, and have been implicated in regeneration. The aim of this study was to examine the distribution of BDNF and TrkB in dorsal column axons which regenerated into a peripheral nerve graft. BDNF-stained axons were found in all regions of the graft. BDNF was also expressed in small neurons in the superficial dorsal horn adjacent to the graft. TrkB was not found in any regenerating axons. Thus BDNF and TrkB are differentially expressed in regenerating dorsal column axons. In these axons BDNF may play a role that is independent of TrkB.</abstract><cop>Hagerstown, MD</cop><pub>Lippincott-Raven Publishers</pub><pmid>9295095</pmid><doi>10.1097/00001756-199708180-00004</doi><tpages>5</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0959-4965 |
| ispartof | Neuroreport, 1997-08, Vol.8 (12), p.2655-2659 |
| issn | 0959-4965 1473-558X |
| language | eng |
| recordid | cdi_proquest_miscellaneous_79276765 |
| source | MEDLINE; Journals@Ovid Complete |
| subjects | Animals Axons - chemistry Axons - physiology Biochemistry and metabolism Biological and medical sciences Brain-Derived Neurotrophic Factor - analysis Central nervous system Female Fundamental and applied biological sciences. Psychology Immunohistochemistry Nerve Regeneration - physiology Nerve Tissue Proteins - analysis Peripheral Nerves - transplantation Rats Rats, Sprague-Dawley Receptor Protein-Tyrosine Kinases - analysis Receptor, Ciliary Neurotrophic Factor Receptors, Nerve Growth Factor - analysis Vertebrates: nervous system and sense organs |
| title | Differential distribution of BDNF and TRKB in regenerating dorsal column axons |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-21T08%3A56%3A04IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Differential%20distribution%20of%20BDNF%20and%20TRKB%20in%20regenerating%20dorsal%20column%20axons&rft.jtitle=Neuroreport&rft.au=Cameron,%20Adrian%20A&rft.date=1997-08-18&rft.volume=8&rft.issue=12&rft.spage=2655&rft.epage=2659&rft.pages=2655-2659&rft.issn=0959-4965&rft.eissn=1473-558X&rft_id=info:doi/10.1097/00001756-199708180-00004&rft_dat=%3Cproquest_cross%3E79276765%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=16435445&rft_id=info:pmid/9295095&rfr_iscdi=true |