Regulation of Glucose Transport, and Glucose Transporters Expression and Trafficking in the Heart: Studies in Cardiac Myocytes
Cardiac muscle is characterized by a high rate of glucose consumption. In the absence of insulin, glucose transport into cardiomyocytes limits the rate of glucose utilization and therefore it is important to understand the regulation of glucose transporters. Cardiac muscle cells express 2 distinct g...
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Veröffentlicht in: | The American journal of cardiology 1997-08, Vol.80 (3), p.65A-76A |
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container_title | The American journal of cardiology |
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creator | Zorzano, Antonio Sevilla, Lidia Camps, Marta Becker, Christoph Meyer, Julia Kammermeier, Helmut Muñoz, Purificación Gumà, Anna Testar, Xavier Palacín, Manuel Blasi, Joan Fischer, Yvan |
description | Cardiac muscle is characterized by a high rate of glucose consumption. In the absence of insulin, glucose transport into cardiomyocytes limits the rate of glucose utilization and therefore it is important to understand the regulation of glucose transporters. Cardiac muscle cells express 2 distinct glucose transporters, GLUT4 and GLUT1; although GLUT4 is quantitatively the more important glucose transporter expressed in heart, GLUT1 is also expressed at a substantial level. In isolated rat cardiomyocytes, insulin acutely stimulates glucose transport and translocates both GLUT4 and GLUT1 from an intracellular site to the cell surface. Recent evidence indicates the existence of at least 2 distinct intracellular membrane populations enriched in GLUT4 with a different protein composition. Elucidation of the intracellular location of these 2 GLUT4 vesicle pools in cardiac myocytes, their role in GLUT4 trafficking, and their relation to insulin-induced GLUT4 translocation needs to be addressed. |
doi_str_mv | 10.1016/S0002-9149(97)00459-1 |
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In the absence of insulin, glucose transport into cardiomyocytes limits the rate of glucose utilization and therefore it is important to understand the regulation of glucose transporters. Cardiac muscle cells express 2 distinct glucose transporters, GLUT4 and GLUT1; although GLUT4 is quantitatively the more important glucose transporter expressed in heart, GLUT1 is also expressed at a substantial level. In isolated rat cardiomyocytes, insulin acutely stimulates glucose transport and translocates both GLUT4 and GLUT1 from an intracellular site to the cell surface. Recent evidence indicates the existence of at least 2 distinct intracellular membrane populations enriched in GLUT4 with a different protein composition. Elucidation of the intracellular location of these 2 GLUT4 vesicle pools in cardiac myocytes, their role in GLUT4 trafficking, and their relation to insulin-induced GLUT4 translocation needs to be addressed.</description><identifier>ISSN: 0002-9149</identifier><identifier>EISSN: 1879-1913</identifier><identifier>DOI: 10.1016/S0002-9149(97)00459-1</identifier><identifier>PMID: 9293957</identifier><identifier>CODEN: AJCDAG</identifier><language>eng</language><publisher>New York, NY: Elsevier Inc</publisher><subject>Animals ; Biological and medical sciences ; Biological Transport, Active ; Cardiovascular system ; Circulatory system ; Diabetes ; Diabetes Mellitus, Experimental - metabolism ; Fasting - metabolism ; Gene Expression Regulation ; Glucose ; Glucose - metabolism ; Glucose Transporter Type 1 ; Glucose Transporter Type 4 ; Heart ; Insulin ; Investigative techniques, diagnostic techniques (general aspects) ; Kinases ; Medical sciences ; Monosaccharide Transport Proteins - metabolism ; Muscle Proteins ; Muscular system ; Myocardium - cytology ; Myocardium - metabolism ; Pathology. 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In the absence of insulin, glucose transport into cardiomyocytes limits the rate of glucose utilization and therefore it is important to understand the regulation of glucose transporters. Cardiac muscle cells express 2 distinct glucose transporters, GLUT4 and GLUT1; although GLUT4 is quantitatively the more important glucose transporter expressed in heart, GLUT1 is also expressed at a substantial level. In isolated rat cardiomyocytes, insulin acutely stimulates glucose transport and translocates both GLUT4 and GLUT1 from an intracellular site to the cell surface. Recent evidence indicates the existence of at least 2 distinct intracellular membrane populations enriched in GLUT4 with a different protein composition. Elucidation of the intracellular location of these 2 GLUT4 vesicle pools in cardiac myocytes, their role in GLUT4 trafficking, and their relation to insulin-induced GLUT4 translocation needs to be addressed.</description><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Biological Transport, Active</subject><subject>Cardiovascular system</subject><subject>Circulatory system</subject><subject>Diabetes</subject><subject>Diabetes Mellitus, Experimental - metabolism</subject><subject>Fasting - metabolism</subject><subject>Gene Expression Regulation</subject><subject>Glucose</subject><subject>Glucose - metabolism</subject><subject>Glucose Transporter Type 1</subject><subject>Glucose Transporter Type 4</subject><subject>Heart</subject><subject>Insulin</subject><subject>Investigative techniques, diagnostic techniques (general aspects)</subject><subject>Kinases</subject><subject>Medical sciences</subject><subject>Monosaccharide Transport Proteins - metabolism</subject><subject>Muscle Proteins</subject><subject>Muscular system</subject><subject>Myocardium - cytology</subject><subject>Myocardium - metabolism</subject><subject>Pathology. 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In the absence of insulin, glucose transport into cardiomyocytes limits the rate of glucose utilization and therefore it is important to understand the regulation of glucose transporters. Cardiac muscle cells express 2 distinct glucose transporters, GLUT4 and GLUT1; although GLUT4 is quantitatively the more important glucose transporter expressed in heart, GLUT1 is also expressed at a substantial level. In isolated rat cardiomyocytes, insulin acutely stimulates glucose transport and translocates both GLUT4 and GLUT1 from an intracellular site to the cell surface. Recent evidence indicates the existence of at least 2 distinct intracellular membrane populations enriched in GLUT4 with a different protein composition. Elucidation of the intracellular location of these 2 GLUT4 vesicle pools in cardiac myocytes, their role in GLUT4 trafficking, and their relation to insulin-induced GLUT4 translocation needs to be addressed.</abstract><cop>New York, NY</cop><pub>Elsevier Inc</pub><pmid>9293957</pmid><doi>10.1016/S0002-9149(97)00459-1</doi></addata></record> |
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subjects | Animals Biological and medical sciences Biological Transport, Active Cardiovascular system Circulatory system Diabetes Diabetes Mellitus, Experimental - metabolism Fasting - metabolism Gene Expression Regulation Glucose Glucose - metabolism Glucose Transporter Type 1 Glucose Transporter Type 4 Heart Insulin Investigative techniques, diagnostic techniques (general aspects) Kinases Medical sciences Monosaccharide Transport Proteins - metabolism Muscle Proteins Muscular system Myocardium - cytology Myocardium - metabolism Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques Proteins Rats RNA, Messenger - analysis Rodents Thyroid Hormones - physiology |
title | Regulation of Glucose Transport, and Glucose Transporters Expression and Trafficking in the Heart: Studies in Cardiac Myocytes |
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