Mechanism of glucose-induced (Na+, K+)-ATPase inhibition in aortic wall of rabbits

Hyperglycaemia decreases (Na+, K+)-ATPase activity in specific tissues by a mechanism whose effects are prevented by aldose reductase inhibitors and by raising plasma myo-inositol. This mechanism was activated and studied in vitro in normal rabbit aortic intima-media. Raising medium glucose to 10 mm...

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Veröffentlicht in:	Diabetologia 1989-07, Vol.32 (7), p.402-408
Hauptverfasser:	SIMMONS, D. A, WINEGRAD, A. I
Format:	Artikel
Sprache:	eng
Schlagworte:	Aldehyde Reductase - antagonists & inhibitors Animals Aorta - enzymology Biological and medical sciences Blood Glucose - metabolism Diabetes Mellitus, Experimental - metabolism Enzymes. Coenzymes. Vitamins. Pigments Fundamental and applied biological sciences. Psychology Imidazoles - pharmacology Imidazolidines In Vitro Techniques Inositol - metabolism Metabolisms and neurohumoral controls Rabbits Sodium-Potassium-Exchanging ATPase - metabolism Vertebrates: anatomy and physiology, studies on body, several organs or systems
Online-Zugang:	Volltext
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