Radioiodinated antibody targeting of the HER-2/ neu oncoprotein

The HER-2/ neu oncogene encodes a 185 kDa phosphoglycoprotein that is overexpressed in breast, ovarian and other cancers. Seven monoclonal antibodies reactive with this oncoprotein were labeled with 131I. In vitro experiments with SKOv3 9002-18 cells determined binding affinity, internalization and...

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Veröffentlicht in:	Nuclear medicine and biology 1997-07, Vol.24 (5), p.451-459
Hauptverfasser:	Xu, F.J., Yu, Y.H., Bae, D.S., Zhao, X.-G., Slade, S.K., Boyer, C.M., Bast, R.C., Zalutsky, M.R.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antibodies, Monoclonal - pharmacokinetics Antibodies, Monoclonal - therapeutic use Biological and medical sciences c- erbB-2 (HER-2/ neu) Contrast media. Radiopharmaceuticals Epitopes Female Humans Iodine Radioisotopes - therapeutic use Medical sciences Mice Mice, Inbred BALB C Mice, Nude Monoclonal antibody Ovarian cancer Pharmacology. Drug treatments Radioimmunotherapy Radioiodination Receptor, ErbB-2 - immunology Tissue Distribution Tumor Tumor Cells, Cultured
Online-Zugang:	Volltext
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