The mechanism and site of action of lidocaine hydrochloride in guinea pig inner ear

Lidocaine was applied to the round window (RW) in order to localize its site of action in the cochlea. Cochlear microphonic (CM), summating potential (SP), and compound action potential (CAP) input/output functions were measured to a 16 kHz tone burst to assess the functional changes of the cochlea....

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Veröffentlicht in:	Acta oto-laryngologica 1997-07, Vol.117 (4), p.523-528
Hauptverfasser:	LAURIKAINEN, E, LIN, X, NUTTALL, A. L, DOLAN, D. F
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Cochlea - metabolism Dose-Response Relationship, Drug Ent. Stomatology Female Guinea Pigs Hair Cells, Auditory, Inner - metabolism Hair Cells, Auditory, Outer - metabolism Lidocaine - administration & dosage Lidocaine - pharmacokinetics Male Medical sciences Organ of Corti - metabolism Pharmacology. Drug treatments
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