Mapping the Peripheral Benzodiazepine Receptor Binding Site by Conformationally Restrained Derivatives of 1-(2-Chlorophenyl)-N-methyl-N-(1-methylpropyl)-3-isoquinolinecarboxamide (PK11195)

A synthetic−computational approach to the study of the binding site of peripheral benzodiazepine receptor (PBR) ligands related to 1-(2-chlorophenyl)-N-methyl-N-(1-methylpropyl)-3-isoquinolinecarboxamide (PK11195, 1) within their receptor has been developed. A wide series of conformationally restrai...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Journal of medicinal chemistry 1997-08, Vol.40 (18), p.2910-2921
Hauptverfasser:	Cappelli, Andrea, Anzini, Maurizio, Vomero, Salvatore, De Benedetti, Pier G, Menziani, Maria Cristina, Giorgi, Gianluca, Manzoni, Cristina
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Binding Sites Biological and medical sciences Brain - metabolism Calorimetry Gabaergic and benzodiazepinic system Indicators and Reagents Isoquinolines - chemical synthesis Isoquinolines - chemistry Isoquinolines - metabolism Kinetics Magnetic Resonance Spectroscopy Male Mass Spectrometry Medical sciences Molecular Conformation Molecular Structure Neuropharmacology Neurotransmitters. Neurotransmission. Receptors Organ Specificity Pharmacology. Drug treatments Radioligand Assay Rats Rats, Inbred Strains Receptors, GABA-A - chemistry Receptors, GABA-A - metabolism Structure-Activity Relationship Tritium
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!