DEPRESSION AND COGNITIVE IMPAIRMENT IN PARKINSON'S DISEASE
Neuropsychological deficits including cognitive impairment as well as depression are among the most frequent and important mental disorders found in patients with Parkinson's disease (PD) It has never been determined, however, whether there is a specific relationship between cognitive impairmen...
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| Veröffentlicht in: | Brain (London, England : 1878) England : 1878), 1989-10, Vol.112 (5), p.1141-1153 |
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| container_title | Brain (London, England : 1878) |
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| creator | STARKSTEIN, SERGIO E. PREZIOSI, THOMAS J. BERTHIER, MARCELO L. BOLDUC, PAULA L. MAYBERG, HELEN S. ROBINSON, ROBERT G. |
| description | Neuropsychological deficits including cognitive impairment as well as depression are among the most frequent and important mental disorders found in patients with Parkinson's disease (PD) It has never been determined, however, whether there is a specific relationship between cognitive impairment and depression. A consecutive series of patients with PD was therefore examined for the presence of depression and neuropsychological deficits. Severity of depression was found to be the single most important factor associated with the severity of cognitive impairment. When PD patients with major depression were compared with an age and stage-matched group of nondepressed patients with PD using a neuropsychological battery, major depressed patients performed significantly worse than the nondepressed patients on all aspects of neuropsychological function tested These impairments were most pronounced on frontal lobe tasks. |
| doi_str_mv | 10.1093/brain/112.5.1141 |
| format | Article |
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A consecutive series of patients with PD was therefore examined for the presence of depression and neuropsychological deficits. Severity of depression was found to be the single most important factor associated with the severity of cognitive impairment. When PD patients with major depression were compared with an age and stage-matched group of nondepressed patients with PD using a neuropsychological battery, major depressed patients performed significantly worse than the nondepressed patients on all aspects of neuropsychological function tested These impairments were most pronounced on frontal lobe tasks.</description><identifier>ISSN: 0006-8950</identifier><identifier>EISSN: 1460-2156</identifier><identifier>DOI: 10.1093/brain/112.5.1141</identifier><identifier>PMID: 2804609</identifier><language>eng</language><publisher>Oxford: Oxford University Press</publisher><subject>Biological and medical sciences ; Cognition ; Cognition Disorders - etiology ; Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases ; Depression - classification ; Depression - etiology ; Depression - psychology ; Humans ; Language Tests ; Levodopa - therapeutic use ; Medical sciences ; Neurology ; Neuropsychological Tests ; Parkinson Disease - complications ; Parkinson Disease - drug therapy ; Regression Analysis</subject><ispartof>Brain (London, England : 1878), 1989-10, Vol.112 (5), p.1141-1153</ispartof><rights>1990 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c361t-7b9c153a23a2a61664ade84b9928cbbe4cb8e0883d21916273dffe28b89235493</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=6639283$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/2804609$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>STARKSTEIN, SERGIO E.</creatorcontrib><creatorcontrib>PREZIOSI, THOMAS J.</creatorcontrib><creatorcontrib>BERTHIER, MARCELO L.</creatorcontrib><creatorcontrib>BOLDUC, PAULA L.</creatorcontrib><creatorcontrib>MAYBERG, HELEN S.</creatorcontrib><creatorcontrib>ROBINSON, ROBERT G.</creatorcontrib><title>DEPRESSION AND COGNITIVE IMPAIRMENT IN PARKINSON'S DISEASE</title><title>Brain (London, England : 1878)</title><addtitle>Brain</addtitle><description>Neuropsychological deficits including cognitive impairment as well as depression are among the most frequent and important mental disorders found in patients with Parkinson's disease (PD) It has never been determined, however, whether there is a specific relationship between cognitive impairment and depression. A consecutive series of patients with PD was therefore examined for the presence of depression and neuropsychological deficits. Severity of depression was found to be the single most important factor associated with the severity of cognitive impairment. When PD patients with major depression were compared with an age and stage-matched group of nondepressed patients with PD using a neuropsychological battery, major depressed patients performed significantly worse than the nondepressed patients on all aspects of neuropsychological function tested These impairments were most pronounced on frontal lobe tasks.</description><subject>Biological and medical sciences</subject><subject>Cognition</subject><subject>Cognition Disorders - etiology</subject><subject>Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases</subject><subject>Depression - classification</subject><subject>Depression - etiology</subject><subject>Depression - psychology</subject><subject>Humans</subject><subject>Language Tests</subject><subject>Levodopa - therapeutic use</subject><subject>Medical sciences</subject><subject>Neurology</subject><subject>Neuropsychological Tests</subject><subject>Parkinson Disease - complications</subject><subject>Parkinson Disease - drug therapy</subject><subject>Regression Analysis</subject><issn>0006-8950</issn><issn>1460-2156</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1989</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo9kEtLw0AURgdRaq3u3QhZiK7SziMzmXEX2tgOtkltqkg3wySZQDR9mGlB_72pLYULd_Gd78I9ANwi2EVQkF5a63LVQwh3aRchD52BNvIYdDGi7By0IYTM5YLCS3Bl7SeEyCOYtUALc9hgog2eBuF0FiaJjCMniAZOPx5Gci7fQ0dOpoGcTcJo7sjImQazFxklcfSYOAOZhEESXoOLQlfW3Bx3B7w9h_P-yB3HQ9kPxm5GGNq6fioyRInGzWiGGPN0briXCoF5lqbGy1JuIOckx0gghn2SF4XBPOUCE-oJ0gEPh7ubev29M3arlqXNTFXplVnvrPIF9qFPWAPCA5jVa2trU6hNXS51_asQVHtd6l-XanQpqva6msrd8fYuXZr8VDj6afL7Y65tpqui1qustCeMMdJ8QRrMPWCl3ZqfU6zrL8V84lM1-liooVjg6JVT5ZM_sut7lA</recordid><startdate>19891001</startdate><enddate>19891001</enddate><creator>STARKSTEIN, SERGIO E.</creator><creator>PREZIOSI, THOMAS J.</creator><creator>BERTHIER, MARCELO L.</creator><creator>BOLDUC, PAULA L.</creator><creator>MAYBERG, HELEN S.</creator><creator>ROBINSON, ROBERT G.</creator><general>Oxford University Press</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19891001</creationdate><title>DEPRESSION AND COGNITIVE IMPAIRMENT IN PARKINSON'S DISEASE</title><author>STARKSTEIN, SERGIO E. ; PREZIOSI, THOMAS J. ; BERTHIER, MARCELO L. ; BOLDUC, PAULA L. ; MAYBERG, HELEN S. ; ROBINSON, ROBERT G.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c361t-7b9c153a23a2a61664ade84b9928cbbe4cb8e0883d21916273dffe28b89235493</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1989</creationdate><topic>Biological and medical sciences</topic><topic>Cognition</topic><topic>Cognition Disorders - etiology</topic><topic>Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases</topic><topic>Depression - classification</topic><topic>Depression - etiology</topic><topic>Depression - psychology</topic><topic>Humans</topic><topic>Language Tests</topic><topic>Levodopa - therapeutic use</topic><topic>Medical sciences</topic><topic>Neurology</topic><topic>Neuropsychological Tests</topic><topic>Parkinson Disease - complications</topic><topic>Parkinson Disease - drug therapy</topic><topic>Regression Analysis</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>STARKSTEIN, SERGIO E.</creatorcontrib><creatorcontrib>PREZIOSI, THOMAS J.</creatorcontrib><creatorcontrib>BERTHIER, MARCELO L.</creatorcontrib><creatorcontrib>BOLDUC, PAULA L.</creatorcontrib><creatorcontrib>MAYBERG, HELEN S.</creatorcontrib><creatorcontrib>ROBINSON, ROBERT G.</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Brain (London, England : 1878)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>STARKSTEIN, SERGIO E.</au><au>PREZIOSI, THOMAS J.</au><au>BERTHIER, MARCELO L.</au><au>BOLDUC, PAULA L.</au><au>MAYBERG, HELEN S.</au><au>ROBINSON, ROBERT G.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>DEPRESSION AND COGNITIVE IMPAIRMENT IN PARKINSON'S DISEASE</atitle><jtitle>Brain (London, England : 1878)</jtitle><addtitle>Brain</addtitle><date>1989-10-01</date><risdate>1989</risdate><volume>112</volume><issue>5</issue><spage>1141</spage><epage>1153</epage><pages>1141-1153</pages><issn>0006-8950</issn><eissn>1460-2156</eissn><abstract>Neuropsychological deficits including cognitive impairment as well as depression are among the most frequent and important mental disorders found in patients with Parkinson's disease (PD) It has never been determined, however, whether there is a specific relationship between cognitive impairment and depression. A consecutive series of patients with PD was therefore examined for the presence of depression and neuropsychological deficits. Severity of depression was found to be the single most important factor associated with the severity of cognitive impairment. When PD patients with major depression were compared with an age and stage-matched group of nondepressed patients with PD using a neuropsychological battery, major depressed patients performed significantly worse than the nondepressed patients on all aspects of neuropsychological function tested These impairments were most pronounced on frontal lobe tasks.</abstract><cop>Oxford</cop><pub>Oxford University Press</pub><pmid>2804609</pmid><doi>10.1093/brain/112.5.1141</doi><tpages>13</tpages></addata></record> |
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| ispartof | Brain (London, England : 1878), 1989-10, Vol.112 (5), p.1141-1153 |
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| source | Oxford University Press Journals Digital Archive legacy; MEDLINE |
| subjects | Biological and medical sciences Cognition Cognition Disorders - etiology Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases Depression - classification Depression - etiology Depression - psychology Humans Language Tests Levodopa - therapeutic use Medical sciences Neurology Neuropsychological Tests Parkinson Disease - complications Parkinson Disease - drug therapy Regression Analysis |
| title | DEPRESSION AND COGNITIVE IMPAIRMENT IN PARKINSON'S DISEASE |
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