Effects of AMPA receptor positive modulators on amphetamine- and dizocilpine-induced locomotion
Two allosteric α-amino-3-hydroxy-5-methylisoxazole-4-propionic acid (AMPA) receptor positive modulators, 1-(1,3-benzodioxol-5-ylcarbonyl)piperidine (1-BCP) and 1-(quinoxalin-6-ylcarbonyl)piperidine (CX516), and the antipsychotic drug, haloperidol, were tested for their ability to inhibit hyperactivi...
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| Veröffentlicht in: | European journal of pharmacology 1997-08, Vol.332 (2), p.115-119 |
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| container_title | European journal of pharmacology |
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| creator | Vanover, Kimberly E |
| description | Two allosteric
α-amino-3-hydroxy-5-methylisoxazole-4-propionic acid (AMPA) receptor positive modulators, 1-(1,3-benzodioxol-5-ylcarbonyl)piperidine (1-BCP) and 1-(quinoxalin-6-ylcarbonyl)piperidine (CX516), and the antipsychotic drug, haloperidol, were tested for their ability to inhibit hyperactivity induced by amphetamine and dizocilpine in mice. Haloperidol (0.03–1.0 mg/kg) and 1-BCP (20.0–120.0 mg/kg) attenuated hyperactivity induced by both amphetamine and dizocilpine, with higher potency against amphetamine. CX516 (30.0–170.0 mg/kg), however, failed to attenuate amphetamine- and dizocilpine-induced hyperactivity up to a dose which decreased spontaneous locomotor activity. These results indicate that AMPA receptor positive modulators may not be uniform with regard to their effects on dopamine-mediated behaviors and their antipsychotic potential. |
| doi_str_mv | 10.1016/S0014-2999(97)01103-5 |
| format | Article |
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α-amino-3-hydroxy-5-methylisoxazole-4-propionic acid (AMPA) receptor positive modulators, 1-(1,3-benzodioxol-5-ylcarbonyl)piperidine (1-BCP) and 1-(quinoxalin-6-ylcarbonyl)piperidine (CX516), and the antipsychotic drug, haloperidol, were tested for their ability to inhibit hyperactivity induced by amphetamine and dizocilpine in mice. Haloperidol (0.03–1.0 mg/kg) and 1-BCP (20.0–120.0 mg/kg) attenuated hyperactivity induced by both amphetamine and dizocilpine, with higher potency against amphetamine. CX516 (30.0–170.0 mg/kg), however, failed to attenuate amphetamine- and dizocilpine-induced hyperactivity up to a dose which decreased spontaneous locomotor activity. These results indicate that AMPA receptor positive modulators may not be uniform with regard to their effects on dopamine-mediated behaviors and their antipsychotic potential.</description><subject>AMPA ( α-amino-3-hydroxy-5-methylisoxazole-4-propionic acid)</subject><subject>Amphetamine - pharmacology</subject><subject>Animals</subject><subject>Antipsychotic</subject><subject>Antipsychotic Agents - pharmacology</subject><subject>Behavior</subject><subject>Biological and medical sciences</subject><subject>Central Nervous System Stimulants - pharmacology</subject><subject>Dioxoles - pharmacology</subject><subject>Dizocilpine Maleate - pharmacology</subject><subject>Dopamine</subject><subject>Dopamine Antagonists - pharmacology</subject><subject>Excitatory Amino Acid Agonists - pharmacology</subject><subject>Excitatory Amino Acid Antagonists - pharmacology</subject><subject>Haloperidol - pharmacology</subject><subject>Locomotion - drug effects</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Mice</subject><subject>Mouse</subject><subject>Neuropharmacology</subject><subject>Pharmacology. Drug treatments</subject><subject>Piperidines - pharmacology</subject><subject>Psycholeptics: tranquillizer, neuroleptic</subject><subject>Psychology. Psychoanalysis. Psychiatry</subject><subject>Psychopharmacology</subject><subject>Receptors, AMPA - metabolism</subject><subject>Schizophrenia</subject><issn>0014-2999</issn><issn>1879-0712</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1997</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkU9r3DAQxUVoSbZpPkJAh1DagxtJtvXnVJaQtIWUBNqehXY8Igq25Up2oPn00WaXveY0MPN7M8N7hJxz9pUzLi9_M8abShhjPhv1hXHO6qo9IiuulamY4uIdWR2QE_Ih50fGWGtEe0yOjdBScrEi9tp7hDnT6On61_2aJgSc5pjoFHOYwxPSIXZL70qrQCN1w_SAsxvCiBV1Y0e78Bwh9NO2EcZuAexoHyEOcQ5x_Ejee9dnPNvXU_L35vrP1Y_q9u77z6v1bQWNlnMFGwS24Z5J8C1IrI1WNXiQRnilhVLgEaXWNXd1Kz3UniHoDSDXzAgm6lPyabd3SvHfgnm2Q8iAfe9GjEu2yogiZ_xNkMumqVvdFLDdgZBizgm9nVIYXPpvObPbBOxrAnZrrzXKviZg26I73x9YNgN2B9Xe8jK_2M9dBtf75EYI-YAJpaUw2zXfdhgW154CJpsh4FjcDSWi2XYxvPHIC-eQo28</recordid><startdate>19970806</startdate><enddate>19970806</enddate><creator>Vanover, Kimberly E</creator><general>Elsevier B.V</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QG</scope><scope>7TK</scope><scope>7U7</scope><scope>C1K</scope><scope>7X8</scope></search><sort><creationdate>19970806</creationdate><title>Effects of AMPA receptor positive modulators on amphetamine- and dizocilpine-induced locomotion</title><author>Vanover, Kimberly E</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c486t-cbec0b1f06cf5c6e39873cfc692f78277cfee68831a356fc3f0ec8bce18092023</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1997</creationdate><topic>AMPA ( α-amino-3-hydroxy-5-methylisoxazole-4-propionic acid)</topic><topic>Amphetamine - pharmacology</topic><topic>Animals</topic><topic>Antipsychotic</topic><topic>Antipsychotic Agents - pharmacology</topic><topic>Behavior</topic><topic>Biological and medical sciences</topic><topic>Central Nervous System Stimulants - pharmacology</topic><topic>Dioxoles - pharmacology</topic><topic>Dizocilpine Maleate - pharmacology</topic><topic>Dopamine</topic><topic>Dopamine Antagonists - pharmacology</topic><topic>Excitatory Amino Acid Agonists - pharmacology</topic><topic>Excitatory Amino Acid Antagonists - pharmacology</topic><topic>Haloperidol - pharmacology</topic><topic>Locomotion - drug effects</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Mice</topic><topic>Mouse</topic><topic>Neuropharmacology</topic><topic>Pharmacology. Drug treatments</topic><topic>Piperidines - pharmacology</topic><topic>Psycholeptics: tranquillizer, neuroleptic</topic><topic>Psychology. Psychoanalysis. Psychiatry</topic><topic>Psychopharmacology</topic><topic>Receptors, AMPA - metabolism</topic><topic>Schizophrenia</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Vanover, Kimberly E</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Animal Behavior Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><collection>MEDLINE - Academic</collection><jtitle>European journal of pharmacology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Vanover, Kimberly E</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effects of AMPA receptor positive modulators on amphetamine- and dizocilpine-induced locomotion</atitle><jtitle>European journal of pharmacology</jtitle><addtitle>Eur J Pharmacol</addtitle><date>1997-08-06</date><risdate>1997</risdate><volume>332</volume><issue>2</issue><spage>115</spage><epage>119</epage><pages>115-119</pages><issn>0014-2999</issn><eissn>1879-0712</eissn><coden>EJPHAZ</coden><abstract>Two allosteric
α-amino-3-hydroxy-5-methylisoxazole-4-propionic acid (AMPA) receptor positive modulators, 1-(1,3-benzodioxol-5-ylcarbonyl)piperidine (1-BCP) and 1-(quinoxalin-6-ylcarbonyl)piperidine (CX516), and the antipsychotic drug, haloperidol, were tested for their ability to inhibit hyperactivity induced by amphetamine and dizocilpine in mice. Haloperidol (0.03–1.0 mg/kg) and 1-BCP (20.0–120.0 mg/kg) attenuated hyperactivity induced by both amphetamine and dizocilpine, with higher potency against amphetamine. CX516 (30.0–170.0 mg/kg), however, failed to attenuate amphetamine- and dizocilpine-induced hyperactivity up to a dose which decreased spontaneous locomotor activity. These results indicate that AMPA receptor positive modulators may not be uniform with regard to their effects on dopamine-mediated behaviors and their antipsychotic potential.</abstract><cop>Amsterdam</cop><pub>Elsevier B.V</pub><pmid>9286612</pmid><doi>10.1016/S0014-2999(97)01103-5</doi><tpages>5</tpages></addata></record> |
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| subjects | AMPA ( α-amino-3-hydroxy-5-methylisoxazole-4-propionic acid) Amphetamine - pharmacology Animals Antipsychotic Antipsychotic Agents - pharmacology Behavior Biological and medical sciences Central Nervous System Stimulants - pharmacology Dioxoles - pharmacology Dizocilpine Maleate - pharmacology Dopamine Dopamine Antagonists - pharmacology Excitatory Amino Acid Agonists - pharmacology Excitatory Amino Acid Antagonists - pharmacology Haloperidol - pharmacology Locomotion - drug effects Male Medical sciences Mice Mouse Neuropharmacology Pharmacology. Drug treatments Piperidines - pharmacology Psycholeptics: tranquillizer, neuroleptic Psychology. Psychoanalysis. Psychiatry Psychopharmacology Receptors, AMPA - metabolism Schizophrenia |
| title | Effects of AMPA receptor positive modulators on amphetamine- and dizocilpine-induced locomotion |
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