Determination of Functional Domains of the Human Transcription Factor PAX8 Responsible for its Nuclear Localization and Transactivating Potential

The conserved structure of the transcription factors of the Pax gene family may reflect functional conservation. We have demonstrated that the human Pax8 transcription factor is organized in several functional domains and contains two regions responsible for its nuclear localization, in addition to...

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Veröffentlicht in:	European journal of biochemistry 1997-08, Vol.247 (3), p.860-869
Hauptverfasser:	Poleev, Andrej, Okladnova, Olga, Musti, Anna‐Maria, Schneider, Susanne, Royer‐Pokora, Brigitta, Plachov, Dimitrij
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals cAMP‐dependent‐protein kinase Cell Line Cell Nucleus - metabolism Cyclic AMP - metabolism DNA-Binding Proteins - chemistry DNA-Binding Proteins - genetics DNA-Binding Proteins - metabolism Gene Expression Regulation, Developmental Genes, Wilms Tumor Humans nuclear localization site Nuclear Proteins Paired Box Transcription Factors Pax gene PAX8 PAX8 Transcription Factor Phosphorylation Promoter Regions, Genetic Rats Recombinant Fusion Proteins - genetics Recombinant Fusion Proteins - metabolism Saccharomyces cerevisiae Proteins Thyroid Gland - cytology Thyroid Gland - metabolism Trans-Activators - chemistry Trans-Activators - genetics Trans-Activators - metabolism transcription activation and repression domains Transcription Factors - genetics Transcriptional Activation Tumor Cells, Cultured Wilms Tumor - genetics
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