Expression of CD44 variants in gastric carcinoma with or without Epstein‐Barr virus
The significance of CD44 variants in gastric carcinoma has not been fully investigated in terms of the pathological features of the carcinoma, including its association with Epstein‐Barr virus (EBV). In this study, a total of 104 primary gastric carcinoma tissues (EBV‐associated gastric carcinomas,...
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| Veröffentlicht in: | International journal of cancer 1997-08, Vol.74 (4), p.450-454 |
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| container_title | International journal of cancer |
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| creator | Chong, Ja‐Mun Fukayama, Masashi Hayashi, Yukiko Funata, Nobuaki Takizawa, Toichirou Koike, Morio Muraoka, Masatoshi Kikuchi‐Yanoshita, Rei Miyaki, Michiko Mizuno, Shoichi |
| description | The significance of CD44 variants in gastric carcinoma has not been fully investigated in terms of the pathological features of the carcinoma, including its association with Epstein‐Barr virus (EBV). In this study, a total of 104 primary gastric carcinoma tissues (EBV‐associated gastric carcinomas, EBVaGC, and EBV‐negative carcinomas) were evaluated by immunohistochemistry. When the immunoreactivity of formalin‐fixed, paraffin‐embedded sections was graded on a scale of 0–3, the frequencies of grades 0–1, 2 and 3 were, respectively, 77%, 16% and 7% using monoclonal antibody (MAb) 3G5, which recognizes V3–5, and 70%, 14% and 15% with MAb 2F10, which recognizes V6. The expression of CD44 variants is independently correlated with lymph node metastasis and EBV‐association in gastric carcinoma. Significant correlations were observed between V3–5 expression and lymph vessel invasion or lymph node metastasis, and between V6 expression and lymph node metastasis. The expression of both variants was significantly correlated with EBV‐association. EBV‐association and lymph node metastasis contributed independently to CD44 variant expression by multivariate analysis. Thus, the mechanism and significance of CD44 variant‐expression are different in gastric carcinomas with or without EBV. EBVaGC is a distinct type of gastric carcinoma which should be considered separately from EBV‐negative carcinoma. Int. J. Cancer 74:450–454, 1997. © 1997 Wiley‐Liss, Inc. |
| doi_str_mv | 10.1002/(SICI)1097-0215(19970822)74:4<450::AID-IJC16>3.0.CO;2-D |
| format | Article |
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In this study, a total of 104 primary gastric carcinoma tissues (EBV‐associated gastric carcinomas, EBVaGC, and EBV‐negative carcinomas) were evaluated by immunohistochemistry. When the immunoreactivity of formalin‐fixed, paraffin‐embedded sections was graded on a scale of 0–3, the frequencies of grades 0–1, 2 and 3 were, respectively, 77%, 16% and 7% using monoclonal antibody (MAb) 3G5, which recognizes V3–5, and 70%, 14% and 15% with MAb 2F10, which recognizes V6. The expression of CD44 variants is independently correlated with lymph node metastasis and EBV‐association in gastric carcinoma. Significant correlations were observed between V3–5 expression and lymph vessel invasion or lymph node metastasis, and between V6 expression and lymph node metastasis. The expression of both variants was significantly correlated with EBV‐association. EBV‐association and lymph node metastasis contributed independently to CD44 variant expression by multivariate analysis. Thus, the mechanism and significance of CD44 variant‐expression are different in gastric carcinomas with or without EBV. EBVaGC is a distinct type of gastric carcinoma which should be considered separately from EBV‐negative carcinoma. Int. J. Cancer 74:450–454, 1997. © 1997 Wiley‐Liss, Inc.</description><identifier>ISSN: 0020-7136</identifier><identifier>EISSN: 1097-0215</identifier><identifier>DOI: 10.1002/(SICI)1097-0215(19970822)74:4<450::AID-IJC16>3.0.CO;2-D</identifier><identifier>PMID: 9291438</identifier><identifier>CODEN: IJCNAW</identifier><language>eng</language><publisher>New York: Wiley Subscription Services, Inc., A Wiley Company</publisher><subject>Adolescent ; Adult ; Aged ; Aged, 80 and over ; Antigens, CD - analysis ; Antigens, CD - biosynthesis ; Antigens, CD - genetics ; Biological and medical sciences ; Female ; Gastroenterology. Liver. Pancreas. Abdomen ; Genetic Variation ; Herpesvirus 4, Human - isolation & purification ; Humans ; Hyaluronan Receptors - analysis ; Hyaluronan Receptors - biosynthesis ; Hyaluronan Receptors - genetics ; Immunohistochemistry ; Intestinal Neoplasms - immunology ; Intestinal Neoplasms - pathology ; Intestinal Neoplasms - virology ; Lymphatic Metastasis ; Male ; Medical sciences ; Middle Aged ; Neoplasm Invasiveness ; RNA, Viral - analysis ; Sex Characteristics ; Stomach Neoplasms - immunology ; Stomach Neoplasms - pathology ; Stomach Neoplasms - surgery ; Stomach Neoplasms - virology ; Stomach. Duodenum. Small intestine. Colon. Rectum. Anus ; Tumors</subject><ispartof>International journal of cancer, 1997-08, Vol.74 (4), p.450-454</ispartof><rights>Copyright © 1997 Wiley‐Liss, Inc.</rights><rights>1997 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c5066-a3abbaaae88d9e823bf973dafd0939945e632e6c8042050bf691aa4c4cba45cf3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2F%28SICI%291097-0215%2819970822%2974%3A4%3C450%3A%3AAID-IJC16%3E3.0.CO%3B2-D$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2F%28SICI%291097-0215%2819970822%2974%3A4%3C450%3A%3AAID-IJC16%3E3.0.CO%3B2-D$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1416,27922,27923,45572,45573</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=2800311$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/9291438$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Chong, Ja‐Mun</creatorcontrib><creatorcontrib>Fukayama, Masashi</creatorcontrib><creatorcontrib>Hayashi, Yukiko</creatorcontrib><creatorcontrib>Funata, Nobuaki</creatorcontrib><creatorcontrib>Takizawa, Toichirou</creatorcontrib><creatorcontrib>Koike, Morio</creatorcontrib><creatorcontrib>Muraoka, Masatoshi</creatorcontrib><creatorcontrib>Kikuchi‐Yanoshita, Rei</creatorcontrib><creatorcontrib>Miyaki, Michiko</creatorcontrib><creatorcontrib>Mizuno, Shoichi</creatorcontrib><title>Expression of CD44 variants in gastric carcinoma with or without Epstein‐Barr virus</title><title>International journal of cancer</title><addtitle>Int J Cancer</addtitle><description>The significance of CD44 variants in gastric carcinoma has not been fully investigated in terms of the pathological features of the carcinoma, including its association with Epstein‐Barr virus (EBV). In this study, a total of 104 primary gastric carcinoma tissues (EBV‐associated gastric carcinomas, EBVaGC, and EBV‐negative carcinomas) were evaluated by immunohistochemistry. When the immunoreactivity of formalin‐fixed, paraffin‐embedded sections was graded on a scale of 0–3, the frequencies of grades 0–1, 2 and 3 were, respectively, 77%, 16% and 7% using monoclonal antibody (MAb) 3G5, which recognizes V3–5, and 70%, 14% and 15% with MAb 2F10, which recognizes V6. The expression of CD44 variants is independently correlated with lymph node metastasis and EBV‐association in gastric carcinoma. Significant correlations were observed between V3–5 expression and lymph vessel invasion or lymph node metastasis, and between V6 expression and lymph node metastasis. The expression of both variants was significantly correlated with EBV‐association. EBV‐association and lymph node metastasis contributed independently to CD44 variant expression by multivariate analysis. Thus, the mechanism and significance of CD44 variant‐expression are different in gastric carcinomas with or without EBV. EBVaGC is a distinct type of gastric carcinoma which should be considered separately from EBV‐negative carcinoma. Int. J. Cancer 74:450–454, 1997. © 1997 Wiley‐Liss, Inc.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Antigens, CD - analysis</subject><subject>Antigens, CD - biosynthesis</subject><subject>Antigens, CD - genetics</subject><subject>Biological and medical sciences</subject><subject>Female</subject><subject>Gastroenterology. Liver. Pancreas. Abdomen</subject><subject>Genetic Variation</subject><subject>Herpesvirus 4, Human - isolation & purification</subject><subject>Humans</subject><subject>Hyaluronan Receptors - analysis</subject><subject>Hyaluronan Receptors - biosynthesis</subject><subject>Hyaluronan Receptors - genetics</subject><subject>Immunohistochemistry</subject><subject>Intestinal Neoplasms - immunology</subject><subject>Intestinal Neoplasms - pathology</subject><subject>Intestinal Neoplasms - virology</subject><subject>Lymphatic Metastasis</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Neoplasm Invasiveness</subject><subject>RNA, Viral - analysis</subject><subject>Sex Characteristics</subject><subject>Stomach Neoplasms - immunology</subject><subject>Stomach Neoplasms - pathology</subject><subject>Stomach Neoplasms - surgery</subject><subject>Stomach Neoplasms - virology</subject><subject>Stomach. Duodenum. Small intestine. Colon. Rectum. Anus</subject><subject>Tumors</subject><issn>0020-7136</issn><issn>1097-0215</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1997</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkc9u00AQxlcIVELhEZB8QKg9OMz-8Z8NCFScAEaVcoAKbqPxZg2LHDvs2i298Qg8I0-C04RcQKr2MNLObz59Mx9jrzhMOYB4dvKhLMpTDjqLQfDkhGudQS7EaaZm6oVKYDY7K-dx-b7g6Us5hWmxfC7i-R02OczcZZNRCeKMy_Q-exDCNwDOE1BH7EgLzZXMJ-xi8WPjbQiua6Oujoq5UtEleUdtHyLXRl8o9N6ZyJA3ru3WFF25_mvU-ZvaDX202ITeuvb3z1-vyfvo0vkhPGT3amqCfbSvx-zizeJj8S4-X74ti7Pz2CSQpjFJqioisnm-0jYXsqp1JldUr0BLrVViUylsanJQAhKo6lRzImWUqUglppbH7OlOd-O774MNPa5dMLZpqLXdEDDTIh3Xl7eCPBU8kwpG8NMONL4LwdsaN96tyV8jB9wmg7hNBrdXxu2V8W8ymCkcXwKIYzJ4kwxKBCyWKHA-Kj_eWxiqtV0ddPdRjP0n-z4FQ03tqTUuHDCRA0jOR-zzDrtyjb3-x92t5v7nbfch_wC5YbbP</recordid><startdate>19970822</startdate><enddate>19970822</enddate><creator>Chong, Ja‐Mun</creator><creator>Fukayama, Masashi</creator><creator>Hayashi, Yukiko</creator><creator>Funata, Nobuaki</creator><creator>Takizawa, Toichirou</creator><creator>Koike, Morio</creator><creator>Muraoka, Masatoshi</creator><creator>Kikuchi‐Yanoshita, Rei</creator><creator>Miyaki, Michiko</creator><creator>Mizuno, Shoichi</creator><general>Wiley Subscription Services, Inc., A Wiley Company</general><general>Wiley-Liss</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TO</scope><scope>7U9</scope><scope>H94</scope><scope>7X8</scope></search><sort><creationdate>19970822</creationdate><title>Expression of CD44 variants in gastric carcinoma with or without Epstein‐Barr virus</title><author>Chong, Ja‐Mun ; Fukayama, Masashi ; Hayashi, Yukiko ; Funata, Nobuaki ; Takizawa, Toichirou ; Koike, Morio ; Muraoka, Masatoshi ; Kikuchi‐Yanoshita, Rei ; Miyaki, Michiko ; Mizuno, Shoichi</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5066-a3abbaaae88d9e823bf973dafd0939945e632e6c8042050bf691aa4c4cba45cf3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1997</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Antigens, CD - analysis</topic><topic>Antigens, CD - biosynthesis</topic><topic>Antigens, CD - genetics</topic><topic>Biological and medical sciences</topic><topic>Female</topic><topic>Gastroenterology. Liver. Pancreas. Abdomen</topic><topic>Genetic Variation</topic><topic>Herpesvirus 4, Human - isolation & purification</topic><topic>Humans</topic><topic>Hyaluronan Receptors - analysis</topic><topic>Hyaluronan Receptors - biosynthesis</topic><topic>Hyaluronan Receptors - genetics</topic><topic>Immunohistochemistry</topic><topic>Intestinal Neoplasms - immunology</topic><topic>Intestinal Neoplasms - pathology</topic><topic>Intestinal Neoplasms - virology</topic><topic>Lymphatic Metastasis</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Neoplasm Invasiveness</topic><topic>RNA, Viral - analysis</topic><topic>Sex Characteristics</topic><topic>Stomach Neoplasms - immunology</topic><topic>Stomach Neoplasms - pathology</topic><topic>Stomach Neoplasms - surgery</topic><topic>Stomach Neoplasms - virology</topic><topic>Stomach. Duodenum. Small intestine. Colon. Rectum. Anus</topic><topic>Tumors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Chong, Ja‐Mun</creatorcontrib><creatorcontrib>Fukayama, Masashi</creatorcontrib><creatorcontrib>Hayashi, Yukiko</creatorcontrib><creatorcontrib>Funata, Nobuaki</creatorcontrib><creatorcontrib>Takizawa, Toichirou</creatorcontrib><creatorcontrib>Koike, Morio</creatorcontrib><creatorcontrib>Muraoka, Masatoshi</creatorcontrib><creatorcontrib>Kikuchi‐Yanoshita, Rei</creatorcontrib><creatorcontrib>Miyaki, Michiko</creatorcontrib><creatorcontrib>Mizuno, Shoichi</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>International journal of cancer</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Chong, Ja‐Mun</au><au>Fukayama, Masashi</au><au>Hayashi, Yukiko</au><au>Funata, Nobuaki</au><au>Takizawa, Toichirou</au><au>Koike, Morio</au><au>Muraoka, Masatoshi</au><au>Kikuchi‐Yanoshita, Rei</au><au>Miyaki, Michiko</au><au>Mizuno, Shoichi</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Expression of CD44 variants in gastric carcinoma with or without Epstein‐Barr virus</atitle><jtitle>International journal of cancer</jtitle><addtitle>Int J Cancer</addtitle><date>1997-08-22</date><risdate>1997</risdate><volume>74</volume><issue>4</issue><spage>450</spage><epage>454</epage><pages>450-454</pages><issn>0020-7136</issn><eissn>1097-0215</eissn><coden>IJCNAW</coden><abstract>The significance of CD44 variants in gastric carcinoma has not been fully investigated in terms of the pathological features of the carcinoma, including its association with Epstein‐Barr virus (EBV). In this study, a total of 104 primary gastric carcinoma tissues (EBV‐associated gastric carcinomas, EBVaGC, and EBV‐negative carcinomas) were evaluated by immunohistochemistry. When the immunoreactivity of formalin‐fixed, paraffin‐embedded sections was graded on a scale of 0–3, the frequencies of grades 0–1, 2 and 3 were, respectively, 77%, 16% and 7% using monoclonal antibody (MAb) 3G5, which recognizes V3–5, and 70%, 14% and 15% with MAb 2F10, which recognizes V6. The expression of CD44 variants is independently correlated with lymph node metastasis and EBV‐association in gastric carcinoma. Significant correlations were observed between V3–5 expression and lymph vessel invasion or lymph node metastasis, and between V6 expression and lymph node metastasis. The expression of both variants was significantly correlated with EBV‐association. EBV‐association and lymph node metastasis contributed independently to CD44 variant expression by multivariate analysis. Thus, the mechanism and significance of CD44 variant‐expression are different in gastric carcinomas with or without EBV. EBVaGC is a distinct type of gastric carcinoma which should be considered separately from EBV‐negative carcinoma. Int. J. Cancer 74:450–454, 1997. © 1997 Wiley‐Liss, Inc.</abstract><cop>New York</cop><pub>Wiley Subscription Services, Inc., A Wiley Company</pub><pmid>9291438</pmid><doi>10.1002/(SICI)1097-0215(19970822)74:4<450::AID-IJC16>3.0.CO;2-D</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | International journal of cancer, 1997-08, Vol.74 (4), p.450-454 |
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| subjects | Adolescent Adult Aged Aged, 80 and over Antigens, CD - analysis Antigens, CD - biosynthesis Antigens, CD - genetics Biological and medical sciences Female Gastroenterology. Liver. Pancreas. Abdomen Genetic Variation Herpesvirus 4, Human - isolation & purification Humans Hyaluronan Receptors - analysis Hyaluronan Receptors - biosynthesis Hyaluronan Receptors - genetics Immunohistochemistry Intestinal Neoplasms - immunology Intestinal Neoplasms - pathology Intestinal Neoplasms - virology Lymphatic Metastasis Male Medical sciences Middle Aged Neoplasm Invasiveness RNA, Viral - analysis Sex Characteristics Stomach Neoplasms - immunology Stomach Neoplasms - pathology Stomach Neoplasms - surgery Stomach Neoplasms - virology Stomach. Duodenum. Small intestine. Colon. Rectum. Anus Tumors |
| title | Expression of CD44 variants in gastric carcinoma with or without Epstein‐Barr virus |
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