Disruption of the MMAC1/PTEN gene by deletion or mutation is a frequent event in malignant melanoma

The MMAC1/PTEN gene, located at 10q23.3, is a candidate tumor suppressor commonly mutated in glioma. We have studied the pattern of deletion, mutation, and expression of MMAC1/PTEN in 35 unrelated melanoma cell lines. Nine (26%) of the cell lines showed partial or complete homozygous deletion of the...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Cancer research (Chicago, Ill.) Ill.), 1997-09, Vol.57 (17), p.3660-3663
Hauptverfasser:	GULDBERG, P, THOR STRATEN, P, BIRCK, A, AHRENKIEL, V, KIRKIN, A. F, ZEUTHEN, J
Format:	Artikel
Sprache:	eng
Schlagworte:	Base Sequence Biological and medical sciences Chromosomes, Human, Pair 10 - genetics Dermatology Exons - genetics Gene Deletion Genes, Tumor Suppressor - genetics Humans Medical sciences Melanoma - genetics Molecular Sequence Data Mutation Phosphoric Monoester Hydrolases Polymerase Chain Reaction Protein Tyrosine Phosphatases - genetics PTEN Phosphohydrolase Skin Neoplasms - genetics Tumor Cells, Cultured Tumor Suppressor Proteins Tumors of the skin and soft tissue. Premalignant lesions
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!