A Maternal Screening Program for Congenital Toxoplasmosis in Quindio, Colombia and Application of Mathematical Models to Estimate Incidences Using Age-Stratified Data
We studied 937 pregnant women from Quindio, Colombia for the presence of specific anti-Toxoplasma gondii IgG antibodies using the indirect immunofluorescence antibody technique (IFAT-IgG). Specific anti-T. gondii IgM antibodies detected using the immunosorbent agglutination assay (ISAgA-IgM) were in...
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| Veröffentlicht in: | The American journal of tropical medicine and hygiene 1997-08, Vol.57 (2), p.180-186 |
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| creator | Gomez-Marin, Jorge Enrique Montoya-de-Londono, Maria Teresa Castano-Osorio, John Carlos |
| description | We studied 937 pregnant women from Quindio, Colombia for the presence of specific anti-Toxoplasma gondii IgG antibodies using the indirect immunofluorescence antibody technique (IFAT-IgG). Specific anti-T. gondii IgM antibodies detected using the immunosorbent agglutination assay (ISAgA-IgM) were investigated in patients with high titers in the IFAT-IgG (dilutions > or = 1:1,024). We used mathematical models based on the age prevalence results of the IFAT-IgG to estimate the number of seroconversions and these were compared with the results predicted by the IgM based-incidence results. We found 15 positive cases by ISAgA-IgM and we were able to follow the children of six mothers from this group in which we found one case of congenital toxoplasmosis with the development of a retinal scar despite prenatal and postnatal treatment. The estimation of new cases for the annual total of pregnancies (approximately 8,000) in the Quindio region was 30-120 according to the ISAgA-IgM results and 57-85 using mathematical models. Thus, mathematical models based on age prevalence can give useful estimations of the magnitude of the problem. |
| doi_str_mv | 10.4269/ajtmh.1997.57.180 |
| format | Article |
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Specific anti-T. gondii IgM antibodies detected using the immunosorbent agglutination assay (ISAgA-IgM) were investigated in patients with high titers in the IFAT-IgG (dilutions > or = 1:1,024). We used mathematical models based on the age prevalence results of the IFAT-IgG to estimate the number of seroconversions and these were compared with the results predicted by the IgM based-incidence results. We found 15 positive cases by ISAgA-IgM and we were able to follow the children of six mothers from this group in which we found one case of congenital toxoplasmosis with the development of a retinal scar despite prenatal and postnatal treatment. The estimation of new cases for the annual total of pregnancies (approximately 8,000) in the Quindio region was 30-120 according to the ISAgA-IgM results and 57-85 using mathematical models. 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Specific anti-T. gondii IgM antibodies detected using the immunosorbent agglutination assay (ISAgA-IgM) were investigated in patients with high titers in the IFAT-IgG (dilutions > or = 1:1,024). We used mathematical models based on the age prevalence results of the IFAT-IgG to estimate the number of seroconversions and these were compared with the results predicted by the IgM based-incidence results. We found 15 positive cases by ISAgA-IgM and we were able to follow the children of six mothers from this group in which we found one case of congenital toxoplasmosis with the development of a retinal scar despite prenatal and postnatal treatment. The estimation of new cases for the annual total of pregnancies (approximately 8,000) in the Quindio region was 30-120 according to the ISAgA-IgM results and 57-85 using mathematical models. Thus, mathematical models based on age prevalence can give useful estimations of the magnitude of the problem.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Age Factors</subject><subject>Agglutination Tests</subject><subject>Animals</subject><subject>Antibodies, Protozoan - analysis</subject><subject>Biological and medical sciences</subject><subject>Child</subject><subject>Colombia - epidemiology</subject><subject>Female</subject><subject>Fluorescent Antibody Technique, Indirect</subject><subject>Follow-Up Studies</subject><subject>Human protozoal diseases</subject><subject>Humans</subject><subject>Immunoglobulin G - analysis</subject><subject>Immunoglobulin M - analysis</subject><subject>Incidence</subject><subject>Infant, Newborn</subject><subject>Infectious diseases</subject><subject>Linear Models</subject><subject>Medical sciences</subject><subject>Parasitic diseases</subject><subject>Pregnancy</subject><subject>Pregnancy Complications, Parasitic - parasitology</subject><subject>Prevalence</subject><subject>Protozoal diseases</subject><subject>Seroepidemiologic Studies</subject><subject>Toxoplasma - immunology</subject><subject>Toxoplasmosis</subject><subject>Toxoplasmosis, Congenital - diagnosis</subject><subject>Toxoplasmosis, Congenital - epidemiology</subject><subject>Toxoplasmosis, Congenital - immunology</subject><subject>Tropical medicine</subject><issn>0002-9637</issn><issn>1476-1645</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1997</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkc-O0zAQxiMEWsrCA3BA8gE4keJ_teNjVRZYaVeAupytSTJJvUrsYqcqvBDPibOt9srJ8sxvvk8zX1G8ZnQpuTIf4X4ad0tmjF6u9JJV9EmxYFKrkim5elosKKW8NEro58WLlO4pZRVn7KK4MLyqKiYWxd81uYUJo4eBbJuI6J3vyfcY-ggj6UIkm-D7XJ0ycBd-h_0AaQzJJeI8-XFwvnXhQ4aGMNYOCPiWrPf7wTUwueBJ6Gb9HY7522SJ29DikMgUyFWaXK4iufaNa9E3mMjPNLuveyy3U8wTncOWfIIJXhbPOhgSvjq_l8X289Xd5mt58-3L9WZ9UzaiUlPZMSGkUaZBQASoG-io1FxgK3kru1pQ4LVmvFshZczIikohWyNbIUAKcVm8P6nuY_h1wDTZ0aUGhwE8hkOy2nCleCX_CzIlqDGVyiA7gU0MKUXs7D7mreMfy6idI7QPEdo5QrvSNkeYZ96cxQ_1iO3jxDmz3H977kPKJ-0i5AOmR4xrQ5WeZd6dsJ3rd0cX0aYRhiGLMns8HrMZf7D7B0gbtM0</recordid><startdate>19970801</startdate><enddate>19970801</enddate><creator>Gomez-Marin, Jorge Enrique</creator><creator>Montoya-de-Londono, Maria Teresa</creator><creator>Castano-Osorio, John Carlos</creator><general>ASTMH</general><general>Allen Press</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>M7N</scope><scope>7X8</scope></search><sort><creationdate>19970801</creationdate><title>A Maternal Screening Program for Congenital Toxoplasmosis in Quindio, Colombia and Application of Mathematical Models to Estimate Incidences Using Age-Stratified Data</title><author>Gomez-Marin, Jorge Enrique ; Montoya-de-Londono, Maria Teresa ; Castano-Osorio, John Carlos</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c386t-f1334969ceaeeaabcaf04723ed42d4fb30a2b712f5e0119480434d94d33a433</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1997</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Age Factors</topic><topic>Agglutination Tests</topic><topic>Animals</topic><topic>Antibodies, Protozoan - analysis</topic><topic>Biological and medical sciences</topic><topic>Child</topic><topic>Colombia - epidemiology</topic><topic>Female</topic><topic>Fluorescent Antibody Technique, Indirect</topic><topic>Follow-Up Studies</topic><topic>Human protozoal diseases</topic><topic>Humans</topic><topic>Immunoglobulin G - analysis</topic><topic>Immunoglobulin M - analysis</topic><topic>Incidence</topic><topic>Infant, Newborn</topic><topic>Infectious diseases</topic><topic>Linear Models</topic><topic>Medical sciences</topic><topic>Parasitic diseases</topic><topic>Pregnancy</topic><topic>Pregnancy Complications, Parasitic - parasitology</topic><topic>Prevalence</topic><topic>Protozoal diseases</topic><topic>Seroepidemiologic Studies</topic><topic>Toxoplasma - immunology</topic><topic>Toxoplasmosis</topic><topic>Toxoplasmosis, Congenital - diagnosis</topic><topic>Toxoplasmosis, Congenital - epidemiology</topic><topic>Toxoplasmosis, Congenital - immunology</topic><topic>Tropical medicine</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Gomez-Marin, Jorge Enrique</creatorcontrib><creatorcontrib>Montoya-de-Londono, Maria Teresa</creatorcontrib><creatorcontrib>Castano-Osorio, John Carlos</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>MEDLINE - Academic</collection><jtitle>The American journal of tropical medicine and hygiene</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Gomez-Marin, Jorge Enrique</au><au>Montoya-de-Londono, Maria Teresa</au><au>Castano-Osorio, John Carlos</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>A Maternal Screening Program for Congenital Toxoplasmosis in Quindio, Colombia and Application of Mathematical Models to Estimate Incidences Using Age-Stratified Data</atitle><jtitle>The American journal of tropical medicine and hygiene</jtitle><addtitle>Am J Trop Med Hyg</addtitle><date>1997-08-01</date><risdate>1997</risdate><volume>57</volume><issue>2</issue><spage>180</spage><epage>186</epage><pages>180-186</pages><issn>0002-9637</issn><eissn>1476-1645</eissn><coden>AJTHAB</coden><abstract>We studied 937 pregnant women from Quindio, Colombia for the presence of specific anti-Toxoplasma gondii IgG antibodies using the indirect immunofluorescence antibody technique (IFAT-IgG). Specific anti-T. gondii IgM antibodies detected using the immunosorbent agglutination assay (ISAgA-IgM) were investigated in patients with high titers in the IFAT-IgG (dilutions > or = 1:1,024). We used mathematical models based on the age prevalence results of the IFAT-IgG to estimate the number of seroconversions and these were compared with the results predicted by the IgM based-incidence results. We found 15 positive cases by ISAgA-IgM and we were able to follow the children of six mothers from this group in which we found one case of congenital toxoplasmosis with the development of a retinal scar despite prenatal and postnatal treatment. The estimation of new cases for the annual total of pregnancies (approximately 8,000) in the Quindio region was 30-120 according to the ISAgA-IgM results and 57-85 using mathematical models. Thus, mathematical models based on age prevalence can give useful estimations of the magnitude of the problem.</abstract><cop>Lawrence, KS</cop><pub>ASTMH</pub><pmid>9288813</pmid><doi>10.4269/ajtmh.1997.57.180</doi><tpages>7</tpages></addata></record> |
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| subjects | Adolescent Adult Age Factors Agglutination Tests Animals Antibodies, Protozoan - analysis Biological and medical sciences Child Colombia - epidemiology Female Fluorescent Antibody Technique, Indirect Follow-Up Studies Human protozoal diseases Humans Immunoglobulin G - analysis Immunoglobulin M - analysis Incidence Infant, Newborn Infectious diseases Linear Models Medical sciences Parasitic diseases Pregnancy Pregnancy Complications, Parasitic - parasitology Prevalence Protozoal diseases Seroepidemiologic Studies Toxoplasma - immunology Toxoplasmosis Toxoplasmosis, Congenital - diagnosis Toxoplasmosis, Congenital - epidemiology Toxoplasmosis, Congenital - immunology Tropical medicine |
| title | A Maternal Screening Program for Congenital Toxoplasmosis in Quindio, Colombia and Application of Mathematical Models to Estimate Incidences Using Age-Stratified Data |
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