NVL: A New Member of the AAA Family of ATPases Localized to the Nucleus
We report the cloning of NVL, a newly recognized human gene that encodes an approximately 110-kDa nuclear protein designated NVLp (nuclear VCP-like protein), which is a member of a rapidly growing family of ATP-binding proteins recently denoted the AAA family (ATPases associated with diverse cellula...
Gespeichert in:
| Veröffentlicht in: | Genomics (San Diego, Calif.) Calif.), 1997-08, Vol.44 (1), p.22-34 |
|---|---|
| Hauptverfasser: | , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 34 |
|---|---|
| container_issue | 1 |
| container_start_page | 22 |
| container_title | Genomics (San Diego, Calif.) |
| container_volume | 44 |
| creator | Germain-Lee, Emily L. Obie, Cassandra Valle, David |
| description | We report the cloning of NVL, a newly recognized human gene that encodes an approximately 110-kDa nuclear protein designated NVLp (nuclear VCP-like protein), which is a member of a rapidly growing family of ATP-binding proteins recently denoted the AAA family (ATPases associated with diverse cellular activities) (W. H. Kunauet al.,1993,Biochimie75: 209–224). NVL was isolated by degenerate PCR using oligonucleotides corresponding to the yeastPEX1gene, which is necessary for peroxisomal biogenesis. Two cDNAs, designated NVL.1 and NVL.2, may represent alternatively spliced forms of a single gene that maps to chromosome 1q41–q42.2. NVL has greatest similarity to the VCP subfamily of AAA proteins, is widely expressed, and encodes a nuclear protein with two highly similar ATP-binding domains. We speculate that NVLp is involved in an ATP-dependent nuclear process. |
| doi_str_mv | 10.1006/geno.1997.4856 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_79266256</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S0888754397948564</els_id><sourcerecordid>16258339</sourcerecordid><originalsourceid>FETCH-LOGICAL-c505t-d60958e7aa55410321a886f64be3847efce9b8c9d02b5e5635a2b368e9b43c333</originalsourceid><addsrcrecordid>eNqFkE1LxDAQhoMoun5cvQk5iLeuadOkE29l8QvW1YN6DWk61Ui71aRV9Nfbuos38TQw87wvw0PIYcymMWPy9AmX7TRWKpumIOQGmcQMVAQylZtkwgAgykTKd8huCC-MMcUh2SbbKgEpVTYhl4vH-RnN6QI_6A02BXraVrR7RprnOb0wjas_x01-f2cCBjpvrandF5a0a3-wRW9r7MM-2apMHfBgPffIw8X5_ewqmt9eXs_yeWQFE11USqYEYGaMEGnMeBIbAFnJtEAOaYaVRVWAVSVLCoFCcmGSgksYtim3nPM9crLqffXtW4-h040LFuvaLLHtg85UImUyBP8D44ECztUATleg9W0IHiv96l1j_KeOmR4V61GxHhXrUfEQOFo390WD5S--djrcj9d3EwZZlTdL68IvlmQKIB1rYIXhoOvdodfBOlxaLJ1H2-mydX998A2lpZQW</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>16258339</pqid></control><display><type>article</type><title>NVL: A New Member of the AAA Family of ATPases Localized to the Nucleus</title><source>MEDLINE</source><source>Elsevier ScienceDirect Journals</source><creator>Germain-Lee, Emily L. ; Obie, Cassandra ; Valle, David</creator><creatorcontrib>Germain-Lee, Emily L. ; Obie, Cassandra ; Valle, David</creatorcontrib><description>We report the cloning of NVL, a newly recognized human gene that encodes an approximately 110-kDa nuclear protein designated NVLp (nuclear VCP-like protein), which is a member of a rapidly growing family of ATP-binding proteins recently denoted the AAA family (ATPases associated with diverse cellular activities) (W. H. Kunauet al.,1993,Biochimie75: 209–224). NVL was isolated by degenerate PCR using oligonucleotides corresponding to the yeastPEX1gene, which is necessary for peroxisomal biogenesis. Two cDNAs, designated NVL.1 and NVL.2, may represent alternatively spliced forms of a single gene that maps to chromosome 1q41–q42.2. NVL has greatest similarity to the VCP subfamily of AAA proteins, is widely expressed, and encodes a nuclear protein with two highly similar ATP-binding domains. We speculate that NVLp is involved in an ATP-dependent nuclear process.</description><identifier>ISSN: 0888-7543</identifier><identifier>EISSN: 1089-8646</identifier><identifier>DOI: 10.1006/geno.1997.4856</identifier><identifier>PMID: 9286697</identifier><language>eng</language><publisher>San Diego, CA: Elsevier Inc</publisher><subject>Adenosine Triphosphatases - chemistry ; Adenosine Triphosphatases - genetics ; Adenosine Triphosphatases - metabolism ; Adenosine Triphosphate - metabolism ; Alternative Splicing - genetics ; Amino Acid Sequence ; Base Sequence ; Biological and medical sciences ; Cell Line ; Chromosome Mapping ; Chromosomes, Human, Pair 1 - genetics ; Cloning, Molecular ; Fundamental and applied biological sciences. Psychology ; Gene Expression Regulation - genetics ; Genes. Genome ; Humans ; In Situ Hybridization, Fluorescence ; Molecular and cellular biology ; Molecular genetics ; Molecular Sequence Data ; Nuclear Proteins - chemistry ; Nuclear Proteins - genetics ; Nuclear Proteins - metabolism ; Phylogeny ; Polymorphism, Genetic ; Sequence Homology, Amino Acid</subject><ispartof>Genomics (San Diego, Calif.), 1997-08, Vol.44 (1), p.22-34</ispartof><rights>1997 Academic Press</rights><rights>1997 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c505t-d60958e7aa55410321a886f64be3847efce9b8c9d02b5e5635a2b368e9b43c333</citedby><cites>FETCH-LOGICAL-c505t-d60958e7aa55410321a886f64be3847efce9b8c9d02b5e5635a2b368e9b43c333</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0888754397948564$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3536,27903,27904,65309</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=2798846$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/9286697$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Germain-Lee, Emily L.</creatorcontrib><creatorcontrib>Obie, Cassandra</creatorcontrib><creatorcontrib>Valle, David</creatorcontrib><title>NVL: A New Member of the AAA Family of ATPases Localized to the Nucleus</title><title>Genomics (San Diego, Calif.)</title><addtitle>Genomics</addtitle><description>We report the cloning of NVL, a newly recognized human gene that encodes an approximately 110-kDa nuclear protein designated NVLp (nuclear VCP-like protein), which is a member of a rapidly growing family of ATP-binding proteins recently denoted the AAA family (ATPases associated with diverse cellular activities) (W. H. Kunauet al.,1993,Biochimie75: 209–224). NVL was isolated by degenerate PCR using oligonucleotides corresponding to the yeastPEX1gene, which is necessary for peroxisomal biogenesis. Two cDNAs, designated NVL.1 and NVL.2, may represent alternatively spliced forms of a single gene that maps to chromosome 1q41–q42.2. NVL has greatest similarity to the VCP subfamily of AAA proteins, is widely expressed, and encodes a nuclear protein with two highly similar ATP-binding domains. We speculate that NVLp is involved in an ATP-dependent nuclear process.</description><subject>Adenosine Triphosphatases - chemistry</subject><subject>Adenosine Triphosphatases - genetics</subject><subject>Adenosine Triphosphatases - metabolism</subject><subject>Adenosine Triphosphate - metabolism</subject><subject>Alternative Splicing - genetics</subject><subject>Amino Acid Sequence</subject><subject>Base Sequence</subject><subject>Biological and medical sciences</subject><subject>Cell Line</subject><subject>Chromosome Mapping</subject><subject>Chromosomes, Human, Pair 1 - genetics</subject><subject>Cloning, Molecular</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Gene Expression Regulation - genetics</subject><subject>Genes. Genome</subject><subject>Humans</subject><subject>In Situ Hybridization, Fluorescence</subject><subject>Molecular and cellular biology</subject><subject>Molecular genetics</subject><subject>Molecular Sequence Data</subject><subject>Nuclear Proteins - chemistry</subject><subject>Nuclear Proteins - genetics</subject><subject>Nuclear Proteins - metabolism</subject><subject>Phylogeny</subject><subject>Polymorphism, Genetic</subject><subject>Sequence Homology, Amino Acid</subject><issn>0888-7543</issn><issn>1089-8646</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1997</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkE1LxDAQhoMoun5cvQk5iLeuadOkE29l8QvW1YN6DWk61Ui71aRV9Nfbuos38TQw87wvw0PIYcymMWPy9AmX7TRWKpumIOQGmcQMVAQylZtkwgAgykTKd8huCC-MMcUh2SbbKgEpVTYhl4vH-RnN6QI_6A02BXraVrR7RprnOb0wjas_x01-f2cCBjpvrandF5a0a3-wRW9r7MM-2apMHfBgPffIw8X5_ewqmt9eXs_yeWQFE11USqYEYGaMEGnMeBIbAFnJtEAOaYaVRVWAVSVLCoFCcmGSgksYtim3nPM9crLqffXtW4-h040LFuvaLLHtg85UImUyBP8D44ECztUATleg9W0IHiv96l1j_KeOmR4V61GxHhXrUfEQOFo390WD5S--djrcj9d3EwZZlTdL68IvlmQKIB1rYIXhoOvdodfBOlxaLJ1H2-mydX998A2lpZQW</recordid><startdate>19970815</startdate><enddate>19970815</enddate><creator>Germain-Lee, Emily L.</creator><creator>Obie, Cassandra</creator><creator>Valle, David</creator><general>Elsevier Inc</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope></search><sort><creationdate>19970815</creationdate><title>NVL: A New Member of the AAA Family of ATPases Localized to the Nucleus</title><author>Germain-Lee, Emily L. ; Obie, Cassandra ; Valle, David</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c505t-d60958e7aa55410321a886f64be3847efce9b8c9d02b5e5635a2b368e9b43c333</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1997</creationdate><topic>Adenosine Triphosphatases - chemistry</topic><topic>Adenosine Triphosphatases - genetics</topic><topic>Adenosine Triphosphatases - metabolism</topic><topic>Adenosine Triphosphate - metabolism</topic><topic>Alternative Splicing - genetics</topic><topic>Amino Acid Sequence</topic><topic>Base Sequence</topic><topic>Biological and medical sciences</topic><topic>Cell Line</topic><topic>Chromosome Mapping</topic><topic>Chromosomes, Human, Pair 1 - genetics</topic><topic>Cloning, Molecular</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Gene Expression Regulation - genetics</topic><topic>Genes. Genome</topic><topic>Humans</topic><topic>In Situ Hybridization, Fluorescence</topic><topic>Molecular and cellular biology</topic><topic>Molecular genetics</topic><topic>Molecular Sequence Data</topic><topic>Nuclear Proteins - chemistry</topic><topic>Nuclear Proteins - genetics</topic><topic>Nuclear Proteins - metabolism</topic><topic>Phylogeny</topic><topic>Polymorphism, Genetic</topic><topic>Sequence Homology, Amino Acid</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Germain-Lee, Emily L.</creatorcontrib><creatorcontrib>Obie, Cassandra</creatorcontrib><creatorcontrib>Valle, David</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Genomics (San Diego, Calif.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Germain-Lee, Emily L.</au><au>Obie, Cassandra</au><au>Valle, David</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>NVL: A New Member of the AAA Family of ATPases Localized to the Nucleus</atitle><jtitle>Genomics (San Diego, Calif.)</jtitle><addtitle>Genomics</addtitle><date>1997-08-15</date><risdate>1997</risdate><volume>44</volume><issue>1</issue><spage>22</spage><epage>34</epage><pages>22-34</pages><issn>0888-7543</issn><eissn>1089-8646</eissn><abstract>We report the cloning of NVL, a newly recognized human gene that encodes an approximately 110-kDa nuclear protein designated NVLp (nuclear VCP-like protein), which is a member of a rapidly growing family of ATP-binding proteins recently denoted the AAA family (ATPases associated with diverse cellular activities) (W. H. Kunauet al.,1993,Biochimie75: 209–224). NVL was isolated by degenerate PCR using oligonucleotides corresponding to the yeastPEX1gene, which is necessary for peroxisomal biogenesis. Two cDNAs, designated NVL.1 and NVL.2, may represent alternatively spliced forms of a single gene that maps to chromosome 1q41–q42.2. NVL has greatest similarity to the VCP subfamily of AAA proteins, is widely expressed, and encodes a nuclear protein with two highly similar ATP-binding domains. We speculate that NVLp is involved in an ATP-dependent nuclear process.</abstract><cop>San Diego, CA</cop><pub>Elsevier Inc</pub><pmid>9286697</pmid><doi>10.1006/geno.1997.4856</doi><tpages>13</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0888-7543 |
| ispartof | Genomics (San Diego, Calif.), 1997-08, Vol.44 (1), p.22-34 |
| issn | 0888-7543 1089-8646 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_79266256 |
| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Adenosine Triphosphatases - chemistry Adenosine Triphosphatases - genetics Adenosine Triphosphatases - metabolism Adenosine Triphosphate - metabolism Alternative Splicing - genetics Amino Acid Sequence Base Sequence Biological and medical sciences Cell Line Chromosome Mapping Chromosomes, Human, Pair 1 - genetics Cloning, Molecular Fundamental and applied biological sciences. Psychology Gene Expression Regulation - genetics Genes. Genome Humans In Situ Hybridization, Fluorescence Molecular and cellular biology Molecular genetics Molecular Sequence Data Nuclear Proteins - chemistry Nuclear Proteins - genetics Nuclear Proteins - metabolism Phylogeny Polymorphism, Genetic Sequence Homology, Amino Acid |
| title | NVL: A New Member of the AAA Family of ATPases Localized to the Nucleus |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-27T06%3A32%3A37IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=NVL:%20A%20New%20Member%20of%20the%20AAA%20Family%20of%20ATPases%20Localized%20to%20the%20Nucleus&rft.jtitle=Genomics%20(San%20Diego,%20Calif.)&rft.au=Germain-Lee,%20Emily%20L.&rft.date=1997-08-15&rft.volume=44&rft.issue=1&rft.spage=22&rft.epage=34&rft.pages=22-34&rft.issn=0888-7543&rft.eissn=1089-8646&rft_id=info:doi/10.1006/geno.1997.4856&rft_dat=%3Cproquest_cross%3E16258339%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=16258339&rft_id=info:pmid/9286697&rft_els_id=S0888754397948564&rfr_iscdi=true |