Effects of glucagon and insulin on poly(ADP-ribose) polymerase activity and blood ketone body ratio after partial hepatectomy in rats
The effects of glucagon and insulin on liver nuclear poly(ADP-ribose) polymerase activity and blood ketone body ratio after rat partial (68%) hepatectomy were examined. Liver weight regeneration rate was enhanced by glucagon and insulin after 5th posthepatectomy day. The maximal value of poly(ADP-ri...
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| Veröffentlicht in: | Nihon geka hokan. Archiv fur japanische Chirurgie 1989-01, Vol.58 (1), p.119-125 |
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| container_title | Nihon geka hokan. Archiv fur japanische Chirurgie |
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| creator | Kawamura, M Sudo, T Fujii, Y Fukunishi, K Yasuda, C Tsubakimoto, R Miyamoto, M Shobu, R Kuyama, T |
| description | The effects of glucagon and insulin on liver nuclear poly(ADP-ribose) polymerase activity and blood ketone body ratio after rat partial (68%) hepatectomy were examined. Liver weight regeneration rate was enhanced by glucagon and insulin after 5th posthepatectomy day. The maximal value of poly(ADP-ribose) polymerase activity without glucagon and insulin was revealed as 368 +/- 64 pmole/mg/min on 5 days after the hepatectomy. In contrast, the enzyme activity with glucagon and insulin reached to the peak value as 253 +/- 42 pmole/mg/min on 2 days after the hepatectomy. The amounts of DNA per nuclear protein showed similar changes with the changes of poly (ADP-ribose) polymerase activity after the hepatectomy. Blood ketone body ratio showed almost similar changes in both groups, except transitional decrease in the group without glucagon and insulin on 5th postoperative day. It is suggested that, to promote remnant liver regeneration, the combined therapy of glucagon and insulin may act directly to nucleic acid metabolism through the changes of poly(ADP-ribose) polymerase activity and preserve energy charge level by the suppression of NAD consumption by massive poly(ADP-ribose) formation. |
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Liver weight regeneration rate was enhanced by glucagon and insulin after 5th posthepatectomy day. The maximal value of poly(ADP-ribose) polymerase activity without glucagon and insulin was revealed as 368 +/- 64 pmole/mg/min on 5 days after the hepatectomy. In contrast, the enzyme activity with glucagon and insulin reached to the peak value as 253 +/- 42 pmole/mg/min on 2 days after the hepatectomy. The amounts of DNA per nuclear protein showed similar changes with the changes of poly (ADP-ribose) polymerase activity after the hepatectomy. Blood ketone body ratio showed almost similar changes in both groups, except transitional decrease in the group without glucagon and insulin on 5th postoperative day. It is suggested that, to promote remnant liver regeneration, the combined therapy of glucagon and insulin may act directly to nucleic acid metabolism through the changes of poly(ADP-ribose) polymerase activity and preserve energy charge level by the suppression of NAD consumption by massive poly(ADP-ribose) formation.</description><identifier>ISSN: 0003-9152</identifier><identifier>PMID: 2508588</identifier><language>jpn</language><publisher>Japan</publisher><subject>Animals ; Cell Nucleus - drug effects ; Cell Nucleus - enzymology ; Drug Evaluation ; Drug Therapy, Combination ; Glucagon - therapeutic use ; Hepatectomy - methods ; Insulin - therapeutic use ; Ketone Bodies - blood ; Liver - drug effects ; Liver - enzymology ; Liver Regeneration - drug effects ; Male ; Poly(ADP-ribose) Polymerases - metabolism ; Rats ; Rats, Inbred Strains</subject><ispartof>Nihon geka hokan. 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Archiv fur japanische Chirurgie</title><addtitle>Nihon Geka Hokan</addtitle><description>The effects of glucagon and insulin on liver nuclear poly(ADP-ribose) polymerase activity and blood ketone body ratio after rat partial (68%) hepatectomy were examined. Liver weight regeneration rate was enhanced by glucagon and insulin after 5th posthepatectomy day. The maximal value of poly(ADP-ribose) polymerase activity without glucagon and insulin was revealed as 368 +/- 64 pmole/mg/min on 5 days after the hepatectomy. In contrast, the enzyme activity with glucagon and insulin reached to the peak value as 253 +/- 42 pmole/mg/min on 2 days after the hepatectomy. The amounts of DNA per nuclear protein showed similar changes with the changes of poly (ADP-ribose) polymerase activity after the hepatectomy. Blood ketone body ratio showed almost similar changes in both groups, except transitional decrease in the group without glucagon and insulin on 5th postoperative day. It is suggested that, to promote remnant liver regeneration, the combined therapy of glucagon and insulin may act directly to nucleic acid metabolism through the changes of poly(ADP-ribose) polymerase activity and preserve energy charge level by the suppression of NAD consumption by massive poly(ADP-ribose) formation.</description><subject>Animals</subject><subject>Cell Nucleus - drug effects</subject><subject>Cell Nucleus - enzymology</subject><subject>Drug Evaluation</subject><subject>Drug Therapy, Combination</subject><subject>Glucagon - therapeutic use</subject><subject>Hepatectomy - methods</subject><subject>Insulin - therapeutic use</subject><subject>Ketone Bodies - blood</subject><subject>Liver - drug effects</subject><subject>Liver - enzymology</subject><subject>Liver Regeneration - drug effects</subject><subject>Male</subject><subject>Poly(ADP-ribose) Polymerases - metabolism</subject><subject>Rats</subject><subject>Rats, Inbred Strains</subject><issn>0003-9152</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1989</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNotkMFOwzAQRH0Alar0E5B8QnCIZG8a1z5WpVCkSnCAc7RJ7GLhxMF2kPIB_Deh9DTa0ZsZaS_InDGWZ4oXcEWWMdqKAcslMMlmZAYFk4WUc_KzM0bXKVJv6NENNR59R7FrqO3i4GxHp7P3brzbPLxmwVY-6vuT0eqAUVOsk_22aTxlKud9Qz918p2mlW9GGjBZT9EkHWiPIVl09EP3mKZN347Tyh8Sr8mlQRf18qwL8v64e9vus8PL0_N2c8h6Djxl0tSCqwokA4O5YEoIDrUwGqHhUubQ1KBAScWUUusCQKzM5E-BohArbvIFuf3v7YP_GnRMZWtjrZ3DTvshlmsFQjC5msCbMzhUrW7KPtgWw1ie_5b_Aq40ad0</recordid><startdate>19890101</startdate><enddate>19890101</enddate><creator>Kawamura, M</creator><creator>Sudo, T</creator><creator>Fujii, Y</creator><creator>Fukunishi, K</creator><creator>Yasuda, C</creator><creator>Tsubakimoto, R</creator><creator>Miyamoto, M</creator><creator>Shobu, R</creator><creator>Kuyama, T</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>19890101</creationdate><title>Effects of glucagon and insulin on poly(ADP-ribose) polymerase activity and blood ketone body ratio after partial hepatectomy in rats</title><author>Kawamura, M ; Sudo, T ; Fujii, Y ; Fukunishi, K ; Yasuda, C ; Tsubakimoto, R ; Miyamoto, M ; Shobu, R ; Kuyama, T</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p121t-8fc619b2802fa36096612c6fea2d18832dc2929890999752264f188b2855641f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>jpn</language><creationdate>1989</creationdate><topic>Animals</topic><topic>Cell Nucleus - drug effects</topic><topic>Cell Nucleus - enzymology</topic><topic>Drug Evaluation</topic><topic>Drug Therapy, Combination</topic><topic>Glucagon - therapeutic use</topic><topic>Hepatectomy - methods</topic><topic>Insulin - therapeutic use</topic><topic>Ketone Bodies - blood</topic><topic>Liver - drug effects</topic><topic>Liver - enzymology</topic><topic>Liver Regeneration - drug effects</topic><topic>Male</topic><topic>Poly(ADP-ribose) Polymerases - metabolism</topic><topic>Rats</topic><topic>Rats, Inbred Strains</topic><toplevel>online_resources</toplevel><creatorcontrib>Kawamura, M</creatorcontrib><creatorcontrib>Sudo, T</creatorcontrib><creatorcontrib>Fujii, Y</creatorcontrib><creatorcontrib>Fukunishi, K</creatorcontrib><creatorcontrib>Yasuda, C</creatorcontrib><creatorcontrib>Tsubakimoto, R</creatorcontrib><creatorcontrib>Miyamoto, M</creatorcontrib><creatorcontrib>Shobu, R</creatorcontrib><creatorcontrib>Kuyama, T</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>Nihon geka hokan. Archiv fur japanische Chirurgie</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kawamura, M</au><au>Sudo, T</au><au>Fujii, Y</au><au>Fukunishi, K</au><au>Yasuda, C</au><au>Tsubakimoto, R</au><au>Miyamoto, M</au><au>Shobu, R</au><au>Kuyama, T</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effects of glucagon and insulin on poly(ADP-ribose) polymerase activity and blood ketone body ratio after partial hepatectomy in rats</atitle><jtitle>Nihon geka hokan. Archiv fur japanische Chirurgie</jtitle><addtitle>Nihon Geka Hokan</addtitle><date>1989-01-01</date><risdate>1989</risdate><volume>58</volume><issue>1</issue><spage>119</spage><epage>125</epage><pages>119-125</pages><issn>0003-9152</issn><abstract>The effects of glucagon and insulin on liver nuclear poly(ADP-ribose) polymerase activity and blood ketone body ratio after rat partial (68%) hepatectomy were examined. Liver weight regeneration rate was enhanced by glucagon and insulin after 5th posthepatectomy day. The maximal value of poly(ADP-ribose) polymerase activity without glucagon and insulin was revealed as 368 +/- 64 pmole/mg/min on 5 days after the hepatectomy. In contrast, the enzyme activity with glucagon and insulin reached to the peak value as 253 +/- 42 pmole/mg/min on 2 days after the hepatectomy. The amounts of DNA per nuclear protein showed similar changes with the changes of poly (ADP-ribose) polymerase activity after the hepatectomy. Blood ketone body ratio showed almost similar changes in both groups, except transitional decrease in the group without glucagon and insulin on 5th postoperative day. It is suggested that, to promote remnant liver regeneration, the combined therapy of glucagon and insulin may act directly to nucleic acid metabolism through the changes of poly(ADP-ribose) polymerase activity and preserve energy charge level by the suppression of NAD consumption by massive poly(ADP-ribose) formation.</abstract><cop>Japan</cop><pmid>2508588</pmid><tpages>7</tpages></addata></record> |
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| identifier | ISSN: 0003-9152 |
| ispartof | Nihon geka hokan. Archiv fur japanische Chirurgie, 1989-01, Vol.58 (1), p.119-125 |
| issn | 0003-9152 |
| language | jpn |
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| source | MEDLINE; Open Access Titles of Japan |
| subjects | Animals Cell Nucleus - drug effects Cell Nucleus - enzymology Drug Evaluation Drug Therapy, Combination Glucagon - therapeutic use Hepatectomy - methods Insulin - therapeutic use Ketone Bodies - blood Liver - drug effects Liver - enzymology Liver Regeneration - drug effects Male Poly(ADP-ribose) Polymerases - metabolism Rats Rats, Inbred Strains |
| title | Effects of glucagon and insulin on poly(ADP-ribose) polymerase activity and blood ketone body ratio after partial hepatectomy in rats |
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