Effect of Rate of Injection on the Neuromuscular Block Produced by Vecuronium
A subparalytic dose (0.015 mg/kg) of vecuronium bromide was administered to matched pairs of patients undergoing routine dental surgery under enflurane-nitrous oxide/oxygen anesthesia either as a rapid bolus injection or as a slow infusion over 5 min. It was demonstrated that bolus injection produce...
Gespeichert in:
| Veröffentlicht in: | Anesthesia and analgesia 1989-11, Vol.69 (5), p.624-626 |
|---|---|
| Hauptverfasser: | , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 626 |
|---|---|
| container_issue | 5 |
| container_start_page | 624 |
| container_title | Anesthesia and analgesia |
| container_volume | 69 |
| creator | Feldman, Stanley A. Soni, Neil Kraayenbrink, Maryke A. |
| description | A subparalytic dose (0.015 mg/kg) of vecuronium bromide was administered to matched pairs of patients undergoing routine dental surgery under enflurane-nitrous oxide/oxygen anesthesia either as a rapid bolus injection or as a slow infusion over 5 min. It was demonstrated that bolus injection produced peak plasma levels of drug considerably greater than those following slow infusion. Time to maximum block was more rapid following bolus (368 ± 84 [SD] sec) than by infusion (615 ± 88 sec), but the maximum block produced, either demonstrated by the reduction in amplitude of T1 from control or the T2:T4 ratio on the integrated electromyogram (Datex IEMG), was similar in each group irrespective of rate of injection, T1 and T4 referring to the first and last twitch in a train of four series. |
| doi_str_mv | 10.1213/00000539-198911000-00014 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_79261994</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>79261994</sourcerecordid><originalsourceid>FETCH-LOGICAL-c4254-57f02cd5206fad481c160b019c6dad1c62dd72a6c0cc803d9a99230c81d2c3543</originalsourceid><addsrcrecordid>eNp1kVFPHCEQgElTo9fTn9CEl_ZtW4bdZZdHa872Equmqb4SbmBzq-xiYYnx38t6p32SQCbMfDMkH4RQYN-AQ_mdzasuZQGylQD5UuQD1QeygJqLoqll-5Escq4suJTyiHyK8W5GWCsOySGvGw5ttSC_V11ncaK-o3_0ZOe4Hu9ypvcjzXvaWnppU_BDipicDvSH83hPr4M3Ca2hmyd6azEDY5-GY3LQaRftyT4uyc356u_Zr-Li6uf67PSiwIrXVVE3HeNoas5Ep03VAoJgGwYShdEGUHBjGq4FMsSWlUZqKXnJsAXDsayrckm-7uY-BP8v2TipoY9ondOj9SmqRnIBUs5guwMx-BiD7dRD6AcdnhQwNZtUrybVm0n1YjK3ft6_kTaDNW-Ne3W5_mVf1xG164IesY__58tKAGeQuWrHPXo32RDvXXq0QW2tdtNWvfeR5TPpHYmg</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>79261994</pqid></control><display><type>article</type><title>Effect of Rate of Injection on the Neuromuscular Block Produced by Vecuronium</title><source>MEDLINE</source><source>Journals@Ovid LWW Legacy Archive</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>Journals@Ovid Complete</source><creator>Feldman, Stanley A. ; Soni, Neil ; Kraayenbrink, Maryke A.</creator><creatorcontrib>Feldman, Stanley A. ; Soni, Neil ; Kraayenbrink, Maryke A.</creatorcontrib><description>A subparalytic dose (0.015 mg/kg) of vecuronium bromide was administered to matched pairs of patients undergoing routine dental surgery under enflurane-nitrous oxide/oxygen anesthesia either as a rapid bolus injection or as a slow infusion over 5 min. It was demonstrated that bolus injection produced peak plasma levels of drug considerably greater than those following slow infusion. Time to maximum block was more rapid following bolus (368 ± 84 [SD] sec) than by infusion (615 ± 88 sec), but the maximum block produced, either demonstrated by the reduction in amplitude of T1 from control or the T2:T4 ratio on the integrated electromyogram (Datex IEMG), was similar in each group irrespective of rate of injection, T1 and T4 referring to the first and last twitch in a train of four series.</description><identifier>ISSN: 0003-2999</identifier><identifier>EISSN: 1526-7598</identifier><identifier>DOI: 10.1213/00000539-198911000-00014</identifier><identifier>PMID: 2572184</identifier><identifier>CODEN: AACRAT</identifier><language>eng</language><publisher>Hagerstown, MD: International Anesthesia Research Society</publisher><subject>Adult ; Anesthetics. Neuromuscular blocking agents ; Biological and medical sciences ; Humans ; Infusions, Intravenous ; Injections, Intravenous ; Medical sciences ; Neuromuscular Junction - drug effects ; Neuropharmacology ; Pharmacology. Drug treatments ; Randomized Controlled Trials as Topic ; Time Factors ; Vecuronium Bromide - administration & dosage ; Vecuronium Bromide - blood</subject><ispartof>Anesthesia and analgesia, 1989-11, Vol.69 (5), p.624-626</ispartof><rights>1989 International Anesthesia Research Society</rights><rights>1991 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttp://ovidsp.ovid.com/ovidweb.cgi?T=JS&NEWS=n&CSC=Y&PAGE=fulltext&D=ovft&AN=00000539-198911000-00014$$EHTML$$P50$$Gwolterskluwer$$H</linktohtml><link.rule.ids>314,776,780,4594,27903,27904,65209</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=19461201$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/2572184$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Feldman, Stanley A.</creatorcontrib><creatorcontrib>Soni, Neil</creatorcontrib><creatorcontrib>Kraayenbrink, Maryke A.</creatorcontrib><title>Effect of Rate of Injection on the Neuromuscular Block Produced by Vecuronium</title><title>Anesthesia and analgesia</title><addtitle>Anesth Analg</addtitle><description>A subparalytic dose (0.015 mg/kg) of vecuronium bromide was administered to matched pairs of patients undergoing routine dental surgery under enflurane-nitrous oxide/oxygen anesthesia either as a rapid bolus injection or as a slow infusion over 5 min. It was demonstrated that bolus injection produced peak plasma levels of drug considerably greater than those following slow infusion. Time to maximum block was more rapid following bolus (368 ± 84 [SD] sec) than by infusion (615 ± 88 sec), but the maximum block produced, either demonstrated by the reduction in amplitude of T1 from control or the T2:T4 ratio on the integrated electromyogram (Datex IEMG), was similar in each group irrespective of rate of injection, T1 and T4 referring to the first and last twitch in a train of four series.</description><subject>Adult</subject><subject>Anesthetics. Neuromuscular blocking agents</subject><subject>Biological and medical sciences</subject><subject>Humans</subject><subject>Infusions, Intravenous</subject><subject>Injections, Intravenous</subject><subject>Medical sciences</subject><subject>Neuromuscular Junction - drug effects</subject><subject>Neuropharmacology</subject><subject>Pharmacology. Drug treatments</subject><subject>Randomized Controlled Trials as Topic</subject><subject>Time Factors</subject><subject>Vecuronium Bromide - administration & dosage</subject><subject>Vecuronium Bromide - blood</subject><issn>0003-2999</issn><issn>1526-7598</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1989</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kVFPHCEQgElTo9fTn9CEl_ZtW4bdZZdHa872Equmqb4SbmBzq-xiYYnx38t6p32SQCbMfDMkH4RQYN-AQ_mdzasuZQGylQD5UuQD1QeygJqLoqll-5Escq4suJTyiHyK8W5GWCsOySGvGw5ttSC_V11ncaK-o3_0ZOe4Hu9ypvcjzXvaWnppU_BDipicDvSH83hPr4M3Ca2hmyd6azEDY5-GY3LQaRftyT4uyc356u_Zr-Li6uf67PSiwIrXVVE3HeNoas5Ep03VAoJgGwYShdEGUHBjGq4FMsSWlUZqKXnJsAXDsayrckm-7uY-BP8v2TipoY9ondOj9SmqRnIBUs5guwMx-BiD7dRD6AcdnhQwNZtUrybVm0n1YjK3ft6_kTaDNW-Ne3W5_mVf1xG164IesY__58tKAGeQuWrHPXo32RDvXXq0QW2tdtNWvfeR5TPpHYmg</recordid><startdate>198911</startdate><enddate>198911</enddate><creator>Feldman, Stanley A.</creator><creator>Soni, Neil</creator><creator>Kraayenbrink, Maryke A.</creator><general>International Anesthesia Research Society</general><general>Lippincott</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>198911</creationdate><title>Effect of Rate of Injection on the Neuromuscular Block Produced by Vecuronium</title><author>Feldman, Stanley A. ; Soni, Neil ; Kraayenbrink, Maryke A.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4254-57f02cd5206fad481c160b019c6dad1c62dd72a6c0cc803d9a99230c81d2c3543</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1989</creationdate><topic>Adult</topic><topic>Anesthetics. Neuromuscular blocking agents</topic><topic>Biological and medical sciences</topic><topic>Humans</topic><topic>Infusions, Intravenous</topic><topic>Injections, Intravenous</topic><topic>Medical sciences</topic><topic>Neuromuscular Junction - drug effects</topic><topic>Neuropharmacology</topic><topic>Pharmacology. Drug treatments</topic><topic>Randomized Controlled Trials as Topic</topic><topic>Time Factors</topic><topic>Vecuronium Bromide - administration & dosage</topic><topic>Vecuronium Bromide - blood</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Feldman, Stanley A.</creatorcontrib><creatorcontrib>Soni, Neil</creatorcontrib><creatorcontrib>Kraayenbrink, Maryke A.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Anesthesia and analgesia</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Feldman, Stanley A.</au><au>Soni, Neil</au><au>Kraayenbrink, Maryke A.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effect of Rate of Injection on the Neuromuscular Block Produced by Vecuronium</atitle><jtitle>Anesthesia and analgesia</jtitle><addtitle>Anesth Analg</addtitle><date>1989-11</date><risdate>1989</risdate><volume>69</volume><issue>5</issue><spage>624</spage><epage>626</epage><pages>624-626</pages><issn>0003-2999</issn><eissn>1526-7598</eissn><coden>AACRAT</coden><abstract>A subparalytic dose (0.015 mg/kg) of vecuronium bromide was administered to matched pairs of patients undergoing routine dental surgery under enflurane-nitrous oxide/oxygen anesthesia either as a rapid bolus injection or as a slow infusion over 5 min. It was demonstrated that bolus injection produced peak plasma levels of drug considerably greater than those following slow infusion. Time to maximum block was more rapid following bolus (368 ± 84 [SD] sec) than by infusion (615 ± 88 sec), but the maximum block produced, either demonstrated by the reduction in amplitude of T1 from control or the T2:T4 ratio on the integrated electromyogram (Datex IEMG), was similar in each group irrespective of rate of injection, T1 and T4 referring to the first and last twitch in a train of four series.</abstract><cop>Hagerstown, MD</cop><pub>International Anesthesia Research Society</pub><pmid>2572184</pmid><doi>10.1213/00000539-198911000-00014</doi><tpages>3</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0003-2999 |
| ispartof | Anesthesia and analgesia, 1989-11, Vol.69 (5), p.624-626 |
| issn | 0003-2999 1526-7598 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_79261994 |
| source | MEDLINE; Journals@Ovid LWW Legacy Archive; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Journals@Ovid Complete |
| subjects | Adult Anesthetics. Neuromuscular blocking agents Biological and medical sciences Humans Infusions, Intravenous Injections, Intravenous Medical sciences Neuromuscular Junction - drug effects Neuropharmacology Pharmacology. Drug treatments Randomized Controlled Trials as Topic Time Factors Vecuronium Bromide - administration & dosage Vecuronium Bromide - blood |
| title | Effect of Rate of Injection on the Neuromuscular Block Produced by Vecuronium |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-27T07%3A07%3A46IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Effect%20of%20Rate%20of%20Injection%20on%20the%20Neuromuscular%20Block%20Produced%20by%20Vecuronium&rft.jtitle=Anesthesia%20and%20analgesia&rft.au=Feldman,%20Stanley%20A.&rft.date=1989-11&rft.volume=69&rft.issue=5&rft.spage=624&rft.epage=626&rft.pages=624-626&rft.issn=0003-2999&rft.eissn=1526-7598&rft.coden=AACRAT&rft_id=info:doi/10.1213/00000539-198911000-00014&rft_dat=%3Cproquest_cross%3E79261994%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=79261994&rft_id=info:pmid/2572184&rfr_iscdi=true |