Allergen Source Materials and Quality Control of Allergenic Extracts
Allergen extracts are prepared from a wide variety of source materials including pollens, fungi, arthropods, animal danders, foods, and dusts. The composition of allergen extracts can vary depending on the allergen source, manufacturing process, and storage conditions. Allergen-specific immunoglobul...
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| Veröffentlicht in: | Methods (San Diego, Calif.) Calif.), 1997-09, Vol.13 (1), p.2-13 |
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| creator | Esch, Robert E |
| description | Allergen extracts are prepared from a wide variety of source materials including pollens, fungi, arthropods, animal danders, foods, and dusts. The composition of allergen extracts can vary depending on the allergen source, manufacturing process, and storage conditions. Allergen-specific immunoglobulin E (IgE) assays and skin tests employ a variety of allergen-containing reagents that confer specificity on the test. Given that the allergen source materials are heterogenous mixtures of proteins, glycoproteins, carbohydrates, and other substances that are not allergenic, it is not unexpected that variability exists between test results obtained with different allergen-containing reagents. Variability within a single manufacturer's allergen product can be controlled by using reproducible extraction and processing procedures, single large lots of allergen source materials, and solid-phase supports. These controls do not, however, ensure the consistency of products between manufacturers or laboratories because allergen source materials, manufacturing procedures, and acceptance criteria for allergen reagents may vary. |
| doi_str_mv | 10.1006/meth.1997.0491 |
| format | Article |
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The composition of allergen extracts can vary depending on the allergen source, manufacturing process, and storage conditions. Allergen-specific immunoglobulin E (IgE) assays and skin tests employ a variety of allergen-containing reagents that confer specificity on the test. Given that the allergen source materials are heterogenous mixtures of proteins, glycoproteins, carbohydrates, and other substances that are not allergenic, it is not unexpected that variability exists between test results obtained with different allergen-containing reagents. Variability within a single manufacturer's allergen product can be controlled by using reproducible extraction and processing procedures, single large lots of allergen source materials, and solid-phase supports. 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The composition of allergen extracts can vary depending on the allergen source, manufacturing process, and storage conditions. Allergen-specific immunoglobulin E (IgE) assays and skin tests employ a variety of allergen-containing reagents that confer specificity on the test. Given that the allergen source materials are heterogenous mixtures of proteins, glycoproteins, carbohydrates, and other substances that are not allergenic, it is not unexpected that variability exists between test results obtained with different allergen-containing reagents. Variability within a single manufacturer's allergen product can be controlled by using reproducible extraction and processing procedures, single large lots of allergen source materials, and solid-phase supports. These controls do not, however, ensure the consistency of products between manufacturers or laboratories because allergen source materials, manufacturing procedures, and acceptance criteria for allergen reagents may vary.</description><subject>Allergens - immunology</subject><subject>Allergens - isolation & purification</subject><subject>Animals</subject><subject>Antigens, Dermatophagoides</subject><subject>Antigens, Plant</subject><subject>Cats</subject><subject>Drug Approval</subject><subject>Enzyme-Linked Immunosorbent Assay</subject><subject>Glycoproteins - immunology</subject><subject>Glycoproteins - standards</subject><subject>Humans</subject><subject>Immune Sera</subject><subject>Immunoglobulin E - blood</subject><subject>Plant Extracts - immunology</subject><subject>Plant Extracts - standards</subject><subject>Plant Proteins - immunology</subject><subject>Plant Proteins - standards</subject><subject>Pollen - immunology</subject><subject>Quality Control</subject><subject>Reference Standards</subject><subject>Saliva - immunology</subject><subject>Skin - immunology</subject><subject>United States</subject><subject>United States Food and Drug Administration</subject><issn>1046-2023</issn><issn>1095-9130</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1997</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kDtPwzAQxy0EKqWwsiFlYks4x24Sj1UpD6kIIWC2HOcMRnkU20H025OohY3pTvo_dPcj5JxCQgGyqwbDe0KFyBPggh6QKQUxjwVlcDjuPItTSNkxOfH-AwBomhcTMhFpQXnGpuR6Udfo3rCNnrveaYweVEBnVe0j1VbRU69qG7bRsmuD6-qoM9FvwOpo9R2c0sGfkiMzJPBsP2fk9Wb1sryL14-398vFOtaMiRBroUqeozLFXFEmdIasFFlRMlMIXgrkajwPiqowYFIOCqEC4JynJRVGp2xGLne9G9d99uiDbKzXWNeqxa73MhdpBvOcDcZkZ9Su896hkRtnG-W2koIcsckRmxyxyRHbELjYN_dlg9Wffc9p0IudjsN7Xxad9Npiq7GyDnWQVWf_q_4B2_J7sQ</recordid><startdate>19970901</startdate><enddate>19970901</enddate><creator>Esch, Robert E</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19970901</creationdate><title>Allergen Source Materials and Quality Control of Allergenic Extracts</title><author>Esch, Robert E</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c339t-c9ab47eaf85a139c6e3b968b3f894b9e4a012708d8f0f240ae0d004442b19fc23</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1997</creationdate><topic>Allergens - immunology</topic><topic>Allergens - isolation & purification</topic><topic>Animals</topic><topic>Antigens, Dermatophagoides</topic><topic>Antigens, Plant</topic><topic>Cats</topic><topic>Drug Approval</topic><topic>Enzyme-Linked Immunosorbent Assay</topic><topic>Glycoproteins - immunology</topic><topic>Glycoproteins - standards</topic><topic>Humans</topic><topic>Immune Sera</topic><topic>Immunoglobulin E - blood</topic><topic>Plant Extracts - immunology</topic><topic>Plant Extracts - standards</topic><topic>Plant Proteins - immunology</topic><topic>Plant Proteins - standards</topic><topic>Pollen - immunology</topic><topic>Quality Control</topic><topic>Reference Standards</topic><topic>Saliva - immunology</topic><topic>Skin - immunology</topic><topic>United States</topic><topic>United States Food and Drug Administration</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Esch, Robert E</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Methods (San Diego, Calif.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Esch, Robert E</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Allergen Source Materials and Quality Control of Allergenic Extracts</atitle><jtitle>Methods (San Diego, Calif.)</jtitle><addtitle>Methods</addtitle><date>1997-09-01</date><risdate>1997</risdate><volume>13</volume><issue>1</issue><spage>2</spage><epage>13</epage><pages>2-13</pages><issn>1046-2023</issn><eissn>1095-9130</eissn><abstract>Allergen extracts are prepared from a wide variety of source materials including pollens, fungi, arthropods, animal danders, foods, and dusts. The composition of allergen extracts can vary depending on the allergen source, manufacturing process, and storage conditions. Allergen-specific immunoglobulin E (IgE) assays and skin tests employ a variety of allergen-containing reagents that confer specificity on the test. Given that the allergen source materials are heterogenous mixtures of proteins, glycoproteins, carbohydrates, and other substances that are not allergenic, it is not unexpected that variability exists between test results obtained with different allergen-containing reagents. Variability within a single manufacturer's allergen product can be controlled by using reproducible extraction and processing procedures, single large lots of allergen source materials, and solid-phase supports. These controls do not, however, ensure the consistency of products between manufacturers or laboratories because allergen source materials, manufacturing procedures, and acceptance criteria for allergen reagents may vary.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>9281463</pmid><doi>10.1006/meth.1997.0491</doi><tpages>12</tpages></addata></record> |
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| ispartof | Methods (San Diego, Calif.), 1997-09, Vol.13 (1), p.2-13 |
| issn | 1046-2023 1095-9130 |
| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Allergens - immunology Allergens - isolation & purification Animals Antigens, Dermatophagoides Antigens, Plant Cats Drug Approval Enzyme-Linked Immunosorbent Assay Glycoproteins - immunology Glycoproteins - standards Humans Immune Sera Immunoglobulin E - blood Plant Extracts - immunology Plant Extracts - standards Plant Proteins - immunology Plant Proteins - standards Pollen - immunology Quality Control Reference Standards Saliva - immunology Skin - immunology United States United States Food and Drug Administration |
| title | Allergen Source Materials and Quality Control of Allergenic Extracts |
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