Mitochondrial protein synthesis may be involved in long-term memory formation

The hypothesis that two qualitatively different stages of cerebral protein synthesis (PS) are required for the formation of long-term memory (LTM) for an active-avoidance task was investigated in rats. Cytoplasmic PS was inhibited with anisomycin (ANI—5.0 mg subcutaneously). When ANI was injected at...

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Veröffentlicht in:	Pharmacology, biochemistry and behavior biochemistry and behavior, 1989-04, Vol.32 (4), p.873-878
Hauptverfasser:	Fride, E., Ben-Or, Sarah, Allweis, C.
Format:	Artikel
Sprache:	eng
Schlagworte:	Amnesia Animal Animals Anisomycin Anisomycin - pharmacology Avoidance Learning - drug effects Biological and medical sciences Brain - drug effects Brain - metabolism Chloramphenicol Chloramphenicol - pharmacology Conditioning Dose-Response Relationship, Drug Fundamental and applied biological sciences. Psychology Learning. Memory Long-term memory Male Memory - drug effects Memory - physiology Mitochondria Mitochondria - drug effects Mitochondria - metabolism Protein Synthesis Inhibitors - pharmacology Protein-synthesis inhibition Psychology. Psychoanalysis. Psychiatry Psychology. Psychophysiology Pyrrolidines - pharmacology Rats Time Factors
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