Combined-modality therapy for squamous carcinoma of the buccal mucosa: Treatment results and prognostic factors
Background Reports on locoregional control and survival of squamous cell carcinoma of buccal mucosa are scarce in literature. In this study, a single institution's experience of combined surgery and postoperative radiotherapy (RT) for buccal mucosal malignancy with favorable results was analyze...
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| Veröffentlicht in: | Head & neck 1997-09, Vol.19 (6), p.506-512 |
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| creator | Fang, Fu-Min Wan Leung, Stephen Huang, Chao-Cheng Liu, Yi-Tien Wang, Chong-Jong Chen, Hui-Chun Sun, Li-Min Huang, David T. |
| description | Background
Reports on locoregional control and survival of squamous cell carcinoma of buccal mucosa are scarce in literature. In this study, a single institution's experience of combined surgery and postoperative radiotherapy (RT) for buccal mucosal malignancy with favorable results was analyzed and presented. The prognostic factors on locoregional control were also discussed.
Methods
From January 1988 to July 1994, 57 patients with squamous cell carcinoma of buccal mucosa treated by surgery and RT were reviewed. The distributions according to American Joint Committee on Cancer (AJCC) staging were: stage II, 6; stage III, 21; and stage IV, 30 patients. Total dose of RT at the buccal area ranged from 45 Gy to 68.4 Gy, median 61.2 Gy. Tumor‐related factors (AJCC stage, T stage, histologic grading, pathologic tumor invasion to skin of cheek, adjacent bony structures, and regional lymph nodes) and treatment‐related factors (surgical margin, radiation dose, and the time interval between operation and RT) were analyzed to determine their influence on locoregional control.
Results
Three‐year actuarial locoregional control rate, overall survival rate, and disease‐specific survival rates were 64%, 55%, and 62%, respectively. Ten of these 22 patients (45%) with recurrent tumors were reoperated, but only 2 patients were successfully salvaged. Positive surgical margin and tumor invasion to skin of cheek were significantly poor prognostic factors on locoregional control by univariate analysis. In multivariate analysis, tumor invasion to skin of cheek was the only prognostic factor (p = .0014).
Conclusions
Locoregional failure was the major cause of death for squamous buccal mucosa cancers managed with surgery and RT. Few recurrences could be detected early and successfully salvaged. Skin of cheek involvement is an important prognostic factor for buccal mucosa cancers. © 1997 John Wiley & Sons, Inc. Head Neck 19:506–512, 1997. |
| doi_str_mv | 10.1002/(SICI)1097-0347(199709)19:6<506::AID-HED8>3.0.CO;2-2 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_79256258</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>79256258</sourcerecordid><originalsourceid>FETCH-LOGICAL-c4938-9eba6c57cbb5f642c3d69eace121de5e7fa3d3310122e836f517e44f39b7aa0e3</originalsourceid><addsrcrecordid>eNqFkV9v0zAUxSMEGmPwEZD8gND2kOI_SRyXCWlkYytMdBKFPV45zg1kJHFnJ4J-exxalQeQeLKte3z88zlRdMrojFHKXx1_WhSLE0aVjKlI5DFTSlJ1wtQ8O01pNp-fLc7jq4vz_I2Y0VmxfM1j_iA63F94OO0TEQsqk8fRE-_vKKUiS_hBdKC4zGWqDiNb2K5seqzizla6bYYNGb6h0-sNqa0j_n7UnR09MdqZpredJraeFKQcjdEt6UZjvZ6TlUM9dNgPxKEf28ET3Vdk7ezX3vqhMaTWZrDOP40e1br1-Gy3HkWf312siqv4enm5KM6uY5MokccKS52ZVJqyTOuAbESVKdQGGWcVpihrLSohGGWcYy6yOmUSk6QWqpRaUxRH0cutb0C4H9EP0DXeYNvqHsN_QCqeZjzNg3C1FRpnvXdYw9o1nXYbYBSmHgCmHmCKFaZYYdtDWCCD0ANA6AGmHkAAhWIJHHiwfb57fyw7rPamu-DD_MVurn3IsXa6N43fy7iUkiv6h-5H0-LmL7T_kP0D7Pc52MZb28YP-HNvq913yKSQKdx-vIT32dsPX25vbqAQvwBUX8Cf</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>79256258</pqid></control><display><type>article</type><title>Combined-modality therapy for squamous carcinoma of the buccal mucosa: Treatment results and prognostic factors</title><source>MEDLINE</source><source>Access via Wiley Online Library</source><creator>Fang, Fu-Min ; Wan Leung, Stephen ; Huang, Chao-Cheng ; Liu, Yi-Tien ; Wang, Chong-Jong ; Chen, Hui-Chun ; Sun, Li-Min ; Huang, David T.</creator><creatorcontrib>Fang, Fu-Min ; Wan Leung, Stephen ; Huang, Chao-Cheng ; Liu, Yi-Tien ; Wang, Chong-Jong ; Chen, Hui-Chun ; Sun, Li-Min ; Huang, David T.</creatorcontrib><description>Background
Reports on locoregional control and survival of squamous cell carcinoma of buccal mucosa are scarce in literature. In this study, a single institution's experience of combined surgery and postoperative radiotherapy (RT) for buccal mucosal malignancy with favorable results was analyzed and presented. The prognostic factors on locoregional control were also discussed.
Methods
From January 1988 to July 1994, 57 patients with squamous cell carcinoma of buccal mucosa treated by surgery and RT were reviewed. The distributions according to American Joint Committee on Cancer (AJCC) staging were: stage II, 6; stage III, 21; and stage IV, 30 patients. Total dose of RT at the buccal area ranged from 45 Gy to 68.4 Gy, median 61.2 Gy. Tumor‐related factors (AJCC stage, T stage, histologic grading, pathologic tumor invasion to skin of cheek, adjacent bony structures, and regional lymph nodes) and treatment‐related factors (surgical margin, radiation dose, and the time interval between operation and RT) were analyzed to determine their influence on locoregional control.
Results
Three‐year actuarial locoregional control rate, overall survival rate, and disease‐specific survival rates were 64%, 55%, and 62%, respectively. Ten of these 22 patients (45%) with recurrent tumors were reoperated, but only 2 patients were successfully salvaged. Positive surgical margin and tumor invasion to skin of cheek were significantly poor prognostic factors on locoregional control by univariate analysis. In multivariate analysis, tumor invasion to skin of cheek was the only prognostic factor (p = .0014).
Conclusions
Locoregional failure was the major cause of death for squamous buccal mucosa cancers managed with surgery and RT. Few recurrences could be detected early and successfully salvaged. Skin of cheek involvement is an important prognostic factor for buccal mucosa cancers. © 1997 John Wiley & Sons, Inc. Head Neck 19:506–512, 1997.</description><identifier>ISSN: 1043-3074</identifier><identifier>EISSN: 1097-0347</identifier><identifier>DOI: 10.1002/(SICI)1097-0347(199709)19:6<506::AID-HED8>3.0.CO;2-2</identifier><identifier>PMID: 9278759</identifier><language>eng</language><publisher>New York: Wiley Subscription Services, Inc., A Wiley Company</publisher><subject>Actuarial Analysis ; Adult ; Aged ; Analysis of Variance ; Biological and medical sciences ; buccal mucosa cancers ; Carcinoma, Squamous Cell - pathology ; Carcinoma, Squamous Cell - radiotherapy ; Carcinoma, Squamous Cell - surgery ; Cause of Death ; Cheek - pathology ; Combined Modality Therapy ; Disease-Free Survival ; Female ; Humans ; Lymph Nodes - pathology ; Male ; Medical sciences ; Middle Aged ; Mouth Mucosa - pathology ; Mouth Mucosa - radiation effects ; Mouth Mucosa - surgery ; Mouth Neoplasms - pathology ; Mouth Neoplasms - radiotherapy ; Mouth Neoplasms - surgery ; Multivariate Analysis ; Neoplasm Invasiveness ; Neoplasm Recurrence, Local - pathology ; Neoplasm Recurrence, Local - prevention & control ; Neoplasm Recurrence, Local - surgery ; Neoplasm Staging ; operation ; Otorhinolaryngology. Stomatology ; Prognosis ; prognostic factors ; radiotherapy ; Radiotherapy Dosage ; Radiotherapy, High-Energy ; Reoperation ; Salvage Therapy ; Skin - pathology ; skin involvement ; Survival Rate ; Time Factors ; Treatment Outcome ; Tumors ; Upper respiratory tract, upper alimentary tract, paranasal sinuses, salivary glands: diseases, semeiology</subject><ispartof>Head & neck, 1997-09, Vol.19 (6), p.506-512</ispartof><rights>Copyright © 1997 John Wiley & Sons, Inc.</rights><rights>1997 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c4938-9eba6c57cbb5f642c3d69eace121de5e7fa3d3310122e836f517e44f39b7aa0e3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2F%28SICI%291097-0347%28199709%2919%3A6%3C506%3A%3AAID-HED8%3E3.0.CO%3B2-2$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2F%28SICI%291097-0347%28199709%2919%3A6%3C506%3A%3AAID-HED8%3E3.0.CO%3B2-2$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>315,781,785,1418,27929,27930,45579,45580</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=2777290$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/9278759$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Fang, Fu-Min</creatorcontrib><creatorcontrib>Wan Leung, Stephen</creatorcontrib><creatorcontrib>Huang, Chao-Cheng</creatorcontrib><creatorcontrib>Liu, Yi-Tien</creatorcontrib><creatorcontrib>Wang, Chong-Jong</creatorcontrib><creatorcontrib>Chen, Hui-Chun</creatorcontrib><creatorcontrib>Sun, Li-Min</creatorcontrib><creatorcontrib>Huang, David T.</creatorcontrib><title>Combined-modality therapy for squamous carcinoma of the buccal mucosa: Treatment results and prognostic factors</title><title>Head & neck</title><addtitle>Head Neck</addtitle><description>Background
Reports on locoregional control and survival of squamous cell carcinoma of buccal mucosa are scarce in literature. In this study, a single institution's experience of combined surgery and postoperative radiotherapy (RT) for buccal mucosal malignancy with favorable results was analyzed and presented. The prognostic factors on locoregional control were also discussed.
Methods
From January 1988 to July 1994, 57 patients with squamous cell carcinoma of buccal mucosa treated by surgery and RT were reviewed. The distributions according to American Joint Committee on Cancer (AJCC) staging were: stage II, 6; stage III, 21; and stage IV, 30 patients. Total dose of RT at the buccal area ranged from 45 Gy to 68.4 Gy, median 61.2 Gy. Tumor‐related factors (AJCC stage, T stage, histologic grading, pathologic tumor invasion to skin of cheek, adjacent bony structures, and regional lymph nodes) and treatment‐related factors (surgical margin, radiation dose, and the time interval between operation and RT) were analyzed to determine their influence on locoregional control.
Results
Three‐year actuarial locoregional control rate, overall survival rate, and disease‐specific survival rates were 64%, 55%, and 62%, respectively. Ten of these 22 patients (45%) with recurrent tumors were reoperated, but only 2 patients were successfully salvaged. Positive surgical margin and tumor invasion to skin of cheek were significantly poor prognostic factors on locoregional control by univariate analysis. In multivariate analysis, tumor invasion to skin of cheek was the only prognostic factor (p = .0014).
Conclusions
Locoregional failure was the major cause of death for squamous buccal mucosa cancers managed with surgery and RT. Few recurrences could be detected early and successfully salvaged. Skin of cheek involvement is an important prognostic factor for buccal mucosa cancers. © 1997 John Wiley & Sons, Inc. Head Neck 19:506–512, 1997.</description><subject>Actuarial Analysis</subject><subject>Adult</subject><subject>Aged</subject><subject>Analysis of Variance</subject><subject>Biological and medical sciences</subject><subject>buccal mucosa cancers</subject><subject>Carcinoma, Squamous Cell - pathology</subject><subject>Carcinoma, Squamous Cell - radiotherapy</subject><subject>Carcinoma, Squamous Cell - surgery</subject><subject>Cause of Death</subject><subject>Cheek - pathology</subject><subject>Combined Modality Therapy</subject><subject>Disease-Free Survival</subject><subject>Female</subject><subject>Humans</subject><subject>Lymph Nodes - pathology</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Mouth Mucosa - pathology</subject><subject>Mouth Mucosa - radiation effects</subject><subject>Mouth Mucosa - surgery</subject><subject>Mouth Neoplasms - pathology</subject><subject>Mouth Neoplasms - radiotherapy</subject><subject>Mouth Neoplasms - surgery</subject><subject>Multivariate Analysis</subject><subject>Neoplasm Invasiveness</subject><subject>Neoplasm Recurrence, Local - pathology</subject><subject>Neoplasm Recurrence, Local - prevention & control</subject><subject>Neoplasm Recurrence, Local - surgery</subject><subject>Neoplasm Staging</subject><subject>operation</subject><subject>Otorhinolaryngology. Stomatology</subject><subject>Prognosis</subject><subject>prognostic factors</subject><subject>radiotherapy</subject><subject>Radiotherapy Dosage</subject><subject>Radiotherapy, High-Energy</subject><subject>Reoperation</subject><subject>Salvage Therapy</subject><subject>Skin - pathology</subject><subject>skin involvement</subject><subject>Survival Rate</subject><subject>Time Factors</subject><subject>Treatment Outcome</subject><subject>Tumors</subject><subject>Upper respiratory tract, upper alimentary tract, paranasal sinuses, salivary glands: diseases, semeiology</subject><issn>1043-3074</issn><issn>1097-0347</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1997</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkV9v0zAUxSMEGmPwEZD8gND2kOI_SRyXCWlkYytMdBKFPV45zg1kJHFnJ4J-exxalQeQeLKte3z88zlRdMrojFHKXx1_WhSLE0aVjKlI5DFTSlJ1wtQ8O01pNp-fLc7jq4vz_I2Y0VmxfM1j_iA63F94OO0TEQsqk8fRE-_vKKUiS_hBdKC4zGWqDiNb2K5seqzizla6bYYNGb6h0-sNqa0j_n7UnR09MdqZpredJraeFKQcjdEt6UZjvZ6TlUM9dNgPxKEf28ET3Vdk7ezX3vqhMaTWZrDOP40e1br1-Gy3HkWf312siqv4enm5KM6uY5MokccKS52ZVJqyTOuAbESVKdQGGWcVpihrLSohGGWcYy6yOmUSk6QWqpRaUxRH0cutb0C4H9EP0DXeYNvqHsN_QCqeZjzNg3C1FRpnvXdYw9o1nXYbYBSmHgCmHmCKFaZYYdtDWCCD0ANA6AGmHkAAhWIJHHiwfb57fyw7rPamu-DD_MVurn3IsXa6N43fy7iUkiv6h-5H0-LmL7T_kP0D7Pc52MZb28YP-HNvq913yKSQKdx-vIT32dsPX25vbqAQvwBUX8Cf</recordid><startdate>199709</startdate><enddate>199709</enddate><creator>Fang, Fu-Min</creator><creator>Wan Leung, Stephen</creator><creator>Huang, Chao-Cheng</creator><creator>Liu, Yi-Tien</creator><creator>Wang, Chong-Jong</creator><creator>Chen, Hui-Chun</creator><creator>Sun, Li-Min</creator><creator>Huang, David T.</creator><general>Wiley Subscription Services, Inc., A Wiley Company</general><general>John Wiley & Sons</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>199709</creationdate><title>Combined-modality therapy for squamous carcinoma of the buccal mucosa: Treatment results and prognostic factors</title><author>Fang, Fu-Min ; Wan Leung, Stephen ; Huang, Chao-Cheng ; Liu, Yi-Tien ; Wang, Chong-Jong ; Chen, Hui-Chun ; Sun, Li-Min ; Huang, David T.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4938-9eba6c57cbb5f642c3d69eace121de5e7fa3d3310122e836f517e44f39b7aa0e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1997</creationdate><topic>Actuarial Analysis</topic><topic>Adult</topic><topic>Aged</topic><topic>Analysis of Variance</topic><topic>Biological and medical sciences</topic><topic>buccal mucosa cancers</topic><topic>Carcinoma, Squamous Cell - pathology</topic><topic>Carcinoma, Squamous Cell - radiotherapy</topic><topic>Carcinoma, Squamous Cell - surgery</topic><topic>Cause of Death</topic><topic>Cheek - pathology</topic><topic>Combined Modality Therapy</topic><topic>Disease-Free Survival</topic><topic>Female</topic><topic>Humans</topic><topic>Lymph Nodes - pathology</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Mouth Mucosa - pathology</topic><topic>Mouth Mucosa - radiation effects</topic><topic>Mouth Mucosa - surgery</topic><topic>Mouth Neoplasms - pathology</topic><topic>Mouth Neoplasms - radiotherapy</topic><topic>Mouth Neoplasms - surgery</topic><topic>Multivariate Analysis</topic><topic>Neoplasm Invasiveness</topic><topic>Neoplasm Recurrence, Local - pathology</topic><topic>Neoplasm Recurrence, Local - prevention & control</topic><topic>Neoplasm Recurrence, Local - surgery</topic><topic>Neoplasm Staging</topic><topic>operation</topic><topic>Otorhinolaryngology. Stomatology</topic><topic>Prognosis</topic><topic>prognostic factors</topic><topic>radiotherapy</topic><topic>Radiotherapy Dosage</topic><topic>Radiotherapy, High-Energy</topic><topic>Reoperation</topic><topic>Salvage Therapy</topic><topic>Skin - pathology</topic><topic>skin involvement</topic><topic>Survival Rate</topic><topic>Time Factors</topic><topic>Treatment Outcome</topic><topic>Tumors</topic><topic>Upper respiratory tract, upper alimentary tract, paranasal sinuses, salivary glands: diseases, semeiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Fang, Fu-Min</creatorcontrib><creatorcontrib>Wan Leung, Stephen</creatorcontrib><creatorcontrib>Huang, Chao-Cheng</creatorcontrib><creatorcontrib>Liu, Yi-Tien</creatorcontrib><creatorcontrib>Wang, Chong-Jong</creatorcontrib><creatorcontrib>Chen, Hui-Chun</creatorcontrib><creatorcontrib>Sun, Li-Min</creatorcontrib><creatorcontrib>Huang, David T.</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Head & neck</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Fang, Fu-Min</au><au>Wan Leung, Stephen</au><au>Huang, Chao-Cheng</au><au>Liu, Yi-Tien</au><au>Wang, Chong-Jong</au><au>Chen, Hui-Chun</au><au>Sun, Li-Min</au><au>Huang, David T.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Combined-modality therapy for squamous carcinoma of the buccal mucosa: Treatment results and prognostic factors</atitle><jtitle>Head & neck</jtitle><addtitle>Head Neck</addtitle><date>1997-09</date><risdate>1997</risdate><volume>19</volume><issue>6</issue><spage>506</spage><epage>512</epage><pages>506-512</pages><issn>1043-3074</issn><eissn>1097-0347</eissn><abstract>Background
Reports on locoregional control and survival of squamous cell carcinoma of buccal mucosa are scarce in literature. In this study, a single institution's experience of combined surgery and postoperative radiotherapy (RT) for buccal mucosal malignancy with favorable results was analyzed and presented. The prognostic factors on locoregional control were also discussed.
Methods
From January 1988 to July 1994, 57 patients with squamous cell carcinoma of buccal mucosa treated by surgery and RT were reviewed. The distributions according to American Joint Committee on Cancer (AJCC) staging were: stage II, 6; stage III, 21; and stage IV, 30 patients. Total dose of RT at the buccal area ranged from 45 Gy to 68.4 Gy, median 61.2 Gy. Tumor‐related factors (AJCC stage, T stage, histologic grading, pathologic tumor invasion to skin of cheek, adjacent bony structures, and regional lymph nodes) and treatment‐related factors (surgical margin, radiation dose, and the time interval between operation and RT) were analyzed to determine their influence on locoregional control.
Results
Three‐year actuarial locoregional control rate, overall survival rate, and disease‐specific survival rates were 64%, 55%, and 62%, respectively. Ten of these 22 patients (45%) with recurrent tumors were reoperated, but only 2 patients were successfully salvaged. Positive surgical margin and tumor invasion to skin of cheek were significantly poor prognostic factors on locoregional control by univariate analysis. In multivariate analysis, tumor invasion to skin of cheek was the only prognostic factor (p = .0014).
Conclusions
Locoregional failure was the major cause of death for squamous buccal mucosa cancers managed with surgery and RT. Few recurrences could be detected early and successfully salvaged. Skin of cheek involvement is an important prognostic factor for buccal mucosa cancers. © 1997 John Wiley & Sons, Inc. Head Neck 19:506–512, 1997.</abstract><cop>New York</cop><pub>Wiley Subscription Services, Inc., A Wiley Company</pub><pmid>9278759</pmid><doi>10.1002/(SICI)1097-0347(199709)19:6<506::AID-HED8>3.0.CO;2-2</doi><tpages>7</tpages></addata></record> |
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| ispartof | Head & neck, 1997-09, Vol.19 (6), p.506-512 |
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| subjects | Actuarial Analysis Adult Aged Analysis of Variance Biological and medical sciences buccal mucosa cancers Carcinoma, Squamous Cell - pathology Carcinoma, Squamous Cell - radiotherapy Carcinoma, Squamous Cell - surgery Cause of Death Cheek - pathology Combined Modality Therapy Disease-Free Survival Female Humans Lymph Nodes - pathology Male Medical sciences Middle Aged Mouth Mucosa - pathology Mouth Mucosa - radiation effects Mouth Mucosa - surgery Mouth Neoplasms - pathology Mouth Neoplasms - radiotherapy Mouth Neoplasms - surgery Multivariate Analysis Neoplasm Invasiveness Neoplasm Recurrence, Local - pathology Neoplasm Recurrence, Local - prevention & control Neoplasm Recurrence, Local - surgery Neoplasm Staging operation Otorhinolaryngology. Stomatology Prognosis prognostic factors radiotherapy Radiotherapy Dosage Radiotherapy, High-Energy Reoperation Salvage Therapy Skin - pathology skin involvement Survival Rate Time Factors Treatment Outcome Tumors Upper respiratory tract, upper alimentary tract, paranasal sinuses, salivary glands: diseases, semeiology |
| title | Combined-modality therapy for squamous carcinoma of the buccal mucosa: Treatment results and prognostic factors |
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