Influence of Cannabinoids on Electrically Evoked Dopamine Release and Cyclic AMP Generation in the Rat Striatum
: Using the endogenous cannabinoid receptor agonist anandamide, the synthetic agonist CP 55940 {[1α,2β(R)5α]‐(−)‐5‐(1,1‐dimethylheptyl)‐2‐[5‐hydroxy‐2‐(3‐hydroxypropyl)cyclohexyl]phenol}, and the specific antagonist SR 141716 [N‐(piperidin‐1‐yl)‐5‐(4‐chlorophenyl)‐1‐(2,4‐dichlorophenyl)‐4‐methyl‐1H‐...
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| Veröffentlicht in: | Journal of neurochemistry 1997-09, Vol.69 (3), p.1131-1137 |
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| creator | Cadogan, Anna‐Karina Alexander, Stephen P. H. Boyd, E. Andrew Kendall, David A. |
| description | : Using the endogenous cannabinoid receptor agonist anandamide, the synthetic agonist CP 55940 {[1α,2β(R)5α]‐(−)‐5‐(1,1‐dimethylheptyl)‐2‐[5‐hydroxy‐2‐(3‐hydroxypropyl)cyclohexyl]phenol}, and the specific antagonist SR 141716 [N‐(piperidin‐1‐yl)‐5‐(4‐chlorophenyl)‐1‐(2,4‐dichlorophenyl)‐4‐methyl‐1H‐pyrazole‐3‐carboxamide hydrochloride], second messenger activation of the central cannabinoid receptor (CB1) was examined in rat striatal and cortical slices. The effects of these cannabinoid ligands on electrically evoked dopamine (DA) release from [3H]dopamine‐prelabelled striatal slices were also investigated. CP 55940 (1 µM) and anandamide (10 µM) caused significant reductions in forskolin‐stimulated cyclic AMP accumulation in rat striatal slices, which were reversed in the presence of SR 141716 (1 µM). CP 55940 (1 µM) had no effect on either KCl‐ or neurotransmitter‐stimulated 3H‐inositol phosphate accumulation in rat cortical slices. CP 55940 and anandamide caused significant reductions in the release of dopamine after electrical stimulation of [3H]dopamine‐prelabelled striatal slices, which were antagonised by SR 141716. SR 141716 alone had no effect on electrically evoked dopamine release from rat striatal slices. These data indicate that the CB1 receptors in rat striatum are negatively linked to adenylyl cyclase and dopamine release. That the CB1 receptor may influence dopamine release in the striatum suggests that cannabinoids play a modulatory role in dopaminergic neuronal pathways. |
| doi_str_mv | 10.1046/j.1471-4159.1997.69031131.x |
| format | Article |
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H. ; Boyd, E. Andrew ; Kendall, David A.</creator><creatorcontrib>Cadogan, Anna‐Karina ; Alexander, Stephen P. H. ; Boyd, E. Andrew ; Kendall, David A.</creatorcontrib><description>: Using the endogenous cannabinoid receptor agonist anandamide, the synthetic agonist CP 55940 {[1α,2β(R)5α]‐(−)‐5‐(1,1‐dimethylheptyl)‐2‐[5‐hydroxy‐2‐(3‐hydroxypropyl)cyclohexyl]phenol}, and the specific antagonist SR 141716 [N‐(piperidin‐1‐yl)‐5‐(4‐chlorophenyl)‐1‐(2,4‐dichlorophenyl)‐4‐methyl‐1H‐pyrazole‐3‐carboxamide hydrochloride], second messenger activation of the central cannabinoid receptor (CB1) was examined in rat striatal and cortical slices. The effects of these cannabinoid ligands on electrically evoked dopamine (DA) release from [3H]dopamine‐prelabelled striatal slices were also investigated. CP 55940 (1 µM) and anandamide (10 µM) caused significant reductions in forskolin‐stimulated cyclic AMP accumulation in rat striatal slices, which were reversed in the presence of SR 141716 (1 µM). CP 55940 (1 µM) had no effect on either KCl‐ or neurotransmitter‐stimulated 3H‐inositol phosphate accumulation in rat cortical slices. CP 55940 and anandamide caused significant reductions in the release of dopamine after electrical stimulation of [3H]dopamine‐prelabelled striatal slices, which were antagonised by SR 141716. SR 141716 alone had no effect on electrically evoked dopamine release from rat striatal slices. These data indicate that the CB1 receptors in rat striatum are negatively linked to adenylyl cyclase and dopamine release. That the CB1 receptor may influence dopamine release in the striatum suggests that cannabinoids play a modulatory role in dopaminergic neuronal pathways.</description><identifier>ISSN: 0022-3042</identifier><identifier>EISSN: 1471-4159</identifier><identifier>DOI: 10.1046/j.1471-4159.1997.69031131.x</identifier><identifier>PMID: 9282935</identifier><identifier>CODEN: JONRA9</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Science Ltd</publisher><subject>Acetylcholine - metabolism ; Adenylyl Cyclases - metabolism ; Animals ; Arachidonic Acids - pharmacology ; Biological and medical sciences ; Cannabinoid receptor ; Cannabinoids - antagonists & inhibitors ; Cannabinoids - pharmacology ; Cerebral Cortex - drug effects ; Cerebral Cortex - physiology ; Corpus Striatum - drug effects ; Corpus Striatum - physiology ; Cyclic AMP ; Cyclic AMP - metabolism ; Cyclohexanols - pharmacology ; Dopamine ; Dopamine - metabolism ; Drug addictions ; Electric Stimulation ; Endocannabinoids ; In Vitro Techniques ; Kinetics ; Male ; Medical sciences ; Phosphatidylinositols - metabolism ; Piperidines - pharmacology ; Polyunsaturated Alkamides ; Potassium Chloride - pharmacology ; Pyrazoles - pharmacology ; Rat ; Rats ; Rats, Wistar ; Receptors, Cannabinoid ; Receptors, Drug - agonists ; Receptors, Drug - physiology ; Rimonabant ; Second Messenger Systems - drug effects ; Second Messenger Systems - physiology ; Striatum ; Toxicology</subject><ispartof>Journal of neurochemistry, 1997-09, Vol.69 (3), p.1131-1137</ispartof><rights>1997 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4721-23224102e5db588e2d3c95a38634c86b7d604115372e78844e99335cfb2a33ad3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1046%2Fj.1471-4159.1997.69031131.x$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1046%2Fj.1471-4159.1997.69031131.x$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,1427,27903,27904,45553,45554,46387,46811</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=2778888$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/9282935$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Cadogan, Anna‐Karina</creatorcontrib><creatorcontrib>Alexander, Stephen P. H.</creatorcontrib><creatorcontrib>Boyd, E. Andrew</creatorcontrib><creatorcontrib>Kendall, David A.</creatorcontrib><title>Influence of Cannabinoids on Electrically Evoked Dopamine Release and Cyclic AMP Generation in the Rat Striatum</title><title>Journal of neurochemistry</title><addtitle>J Neurochem</addtitle><description>: Using the endogenous cannabinoid receptor agonist anandamide, the synthetic agonist CP 55940 {[1α,2β(R)5α]‐(−)‐5‐(1,1‐dimethylheptyl)‐2‐[5‐hydroxy‐2‐(3‐hydroxypropyl)cyclohexyl]phenol}, and the specific antagonist SR 141716 [N‐(piperidin‐1‐yl)‐5‐(4‐chlorophenyl)‐1‐(2,4‐dichlorophenyl)‐4‐methyl‐1H‐pyrazole‐3‐carboxamide hydrochloride], second messenger activation of the central cannabinoid receptor (CB1) was examined in rat striatal and cortical slices. The effects of these cannabinoid ligands on electrically evoked dopamine (DA) release from [3H]dopamine‐prelabelled striatal slices were also investigated. CP 55940 (1 µM) and anandamide (10 µM) caused significant reductions in forskolin‐stimulated cyclic AMP accumulation in rat striatal slices, which were reversed in the presence of SR 141716 (1 µM). CP 55940 (1 µM) had no effect on either KCl‐ or neurotransmitter‐stimulated 3H‐inositol phosphate accumulation in rat cortical slices. CP 55940 and anandamide caused significant reductions in the release of dopamine after electrical stimulation of [3H]dopamine‐prelabelled striatal slices, which were antagonised by SR 141716. SR 141716 alone had no effect on electrically evoked dopamine release from rat striatal slices. These data indicate that the CB1 receptors in rat striatum are negatively linked to adenylyl cyclase and dopamine release. That the CB1 receptor may influence dopamine release in the striatum suggests that cannabinoids play a modulatory role in dopaminergic neuronal pathways.</description><subject>Acetylcholine - metabolism</subject><subject>Adenylyl Cyclases - metabolism</subject><subject>Animals</subject><subject>Arachidonic Acids - pharmacology</subject><subject>Biological and medical sciences</subject><subject>Cannabinoid receptor</subject><subject>Cannabinoids - antagonists & inhibitors</subject><subject>Cannabinoids - pharmacology</subject><subject>Cerebral Cortex - drug effects</subject><subject>Cerebral Cortex - physiology</subject><subject>Corpus Striatum - drug effects</subject><subject>Corpus Striatum - physiology</subject><subject>Cyclic AMP</subject><subject>Cyclic AMP - metabolism</subject><subject>Cyclohexanols - pharmacology</subject><subject>Dopamine</subject><subject>Dopamine - metabolism</subject><subject>Drug addictions</subject><subject>Electric Stimulation</subject><subject>Endocannabinoids</subject><subject>In Vitro Techniques</subject><subject>Kinetics</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Phosphatidylinositols - metabolism</subject><subject>Piperidines - pharmacology</subject><subject>Polyunsaturated Alkamides</subject><subject>Potassium Chloride - pharmacology</subject><subject>Pyrazoles - pharmacology</subject><subject>Rat</subject><subject>Rats</subject><subject>Rats, Wistar</subject><subject>Receptors, Cannabinoid</subject><subject>Receptors, Drug - agonists</subject><subject>Receptors, Drug - physiology</subject><subject>Rimonabant</subject><subject>Second Messenger Systems - drug effects</subject><subject>Second Messenger Systems - physiology</subject><subject>Striatum</subject><subject>Toxicology</subject><issn>0022-3042</issn><issn>1471-4159</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1997</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqVkE9v1DAQxS0EKkvLR0CyBOKW4H-JY3Gq0qUtKlC1cLYcZyK8OPY2TqD77Ztot3vnNBq992aefgi9pySnRJSfNjkVkmaCFiqnSsm8VIRTymn--AKtjtpLtCKEsYwTwV6jNyltCKGlKOkJOlGsYooXKxSvQ-cnCBZw7HBtQjCNC9G1CceA1x7sODhrvN_h9d_4B1p8EbemdwHwHXgwCbAJLa531juLz7_d4ksIMJjRzXEX8Ph7NpoR389nzDj1Z-hVZ3yCt4d5in59Wf-sr7KbH5fX9flNZoVkNGOcMUEJg6JtiqoC1nKrCsOrkgtblY1sSyIoLbhkIKtKCFCK88J2DTOcm5afoo_7u9shPkyQRt27ZMF7EyBOSUvFClbIajZ-3hvtEFMaoNPbwfVm2GlK9IJbb_SCVC9I9YJbP-PWj3P63eHN1PTQHrMHvrP-4aCbNFPsBhOsS0cbk3P5ailxsbf9cx52_9NAf_1eP2_8CZZ3m3k</recordid><startdate>199709</startdate><enddate>199709</enddate><creator>Cadogan, Anna‐Karina</creator><creator>Alexander, Stephen P. H.</creator><creator>Boyd, E. Andrew</creator><creator>Kendall, David A.</creator><general>Blackwell Science Ltd</general><general>Blackwell</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>199709</creationdate><title>Influence of Cannabinoids on Electrically Evoked Dopamine Release and Cyclic AMP Generation in the Rat Striatum</title><author>Cadogan, Anna‐Karina ; Alexander, Stephen P. H. ; Boyd, E. Andrew ; Kendall, David A.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4721-23224102e5db588e2d3c95a38634c86b7d604115372e78844e99335cfb2a33ad3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1997</creationdate><topic>Acetylcholine - metabolism</topic><topic>Adenylyl Cyclases - metabolism</topic><topic>Animals</topic><topic>Arachidonic Acids - pharmacology</topic><topic>Biological and medical sciences</topic><topic>Cannabinoid receptor</topic><topic>Cannabinoids - antagonists & inhibitors</topic><topic>Cannabinoids - pharmacology</topic><topic>Cerebral Cortex - drug effects</topic><topic>Cerebral Cortex - physiology</topic><topic>Corpus Striatum - drug effects</topic><topic>Corpus Striatum - physiology</topic><topic>Cyclic AMP</topic><topic>Cyclic AMP - metabolism</topic><topic>Cyclohexanols - pharmacology</topic><topic>Dopamine</topic><topic>Dopamine - metabolism</topic><topic>Drug addictions</topic><topic>Electric Stimulation</topic><topic>Endocannabinoids</topic><topic>In Vitro Techniques</topic><topic>Kinetics</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Phosphatidylinositols - metabolism</topic><topic>Piperidines - pharmacology</topic><topic>Polyunsaturated Alkamides</topic><topic>Potassium Chloride - pharmacology</topic><topic>Pyrazoles - pharmacology</topic><topic>Rat</topic><topic>Rats</topic><topic>Rats, Wistar</topic><topic>Receptors, Cannabinoid</topic><topic>Receptors, Drug - agonists</topic><topic>Receptors, Drug - physiology</topic><topic>Rimonabant</topic><topic>Second Messenger Systems - drug effects</topic><topic>Second Messenger Systems - physiology</topic><topic>Striatum</topic><topic>Toxicology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Cadogan, Anna‐Karina</creatorcontrib><creatorcontrib>Alexander, Stephen P. H.</creatorcontrib><creatorcontrib>Boyd, E. Andrew</creatorcontrib><creatorcontrib>Kendall, David A.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of neurochemistry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Cadogan, Anna‐Karina</au><au>Alexander, Stephen P. H.</au><au>Boyd, E. Andrew</au><au>Kendall, David A.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Influence of Cannabinoids on Electrically Evoked Dopamine Release and Cyclic AMP Generation in the Rat Striatum</atitle><jtitle>Journal of neurochemistry</jtitle><addtitle>J Neurochem</addtitle><date>1997-09</date><risdate>1997</risdate><volume>69</volume><issue>3</issue><spage>1131</spage><epage>1137</epage><pages>1131-1137</pages><issn>0022-3042</issn><eissn>1471-4159</eissn><coden>JONRA9</coden><abstract>: Using the endogenous cannabinoid receptor agonist anandamide, the synthetic agonist CP 55940 {[1α,2β(R)5α]‐(−)‐5‐(1,1‐dimethylheptyl)‐2‐[5‐hydroxy‐2‐(3‐hydroxypropyl)cyclohexyl]phenol}, and the specific antagonist SR 141716 [N‐(piperidin‐1‐yl)‐5‐(4‐chlorophenyl)‐1‐(2,4‐dichlorophenyl)‐4‐methyl‐1H‐pyrazole‐3‐carboxamide hydrochloride], second messenger activation of the central cannabinoid receptor (CB1) was examined in rat striatal and cortical slices. The effects of these cannabinoid ligands on electrically evoked dopamine (DA) release from [3H]dopamine‐prelabelled striatal slices were also investigated. CP 55940 (1 µM) and anandamide (10 µM) caused significant reductions in forskolin‐stimulated cyclic AMP accumulation in rat striatal slices, which were reversed in the presence of SR 141716 (1 µM). CP 55940 (1 µM) had no effect on either KCl‐ or neurotransmitter‐stimulated 3H‐inositol phosphate accumulation in rat cortical slices. CP 55940 and anandamide caused significant reductions in the release of dopamine after electrical stimulation of [3H]dopamine‐prelabelled striatal slices, which were antagonised by SR 141716. SR 141716 alone had no effect on electrically evoked dopamine release from rat striatal slices. These data indicate that the CB1 receptors in rat striatum are negatively linked to adenylyl cyclase and dopamine release. That the CB1 receptor may influence dopamine release in the striatum suggests that cannabinoids play a modulatory role in dopaminergic neuronal pathways.</abstract><cop>Oxford, UK</cop><pub>Blackwell Science Ltd</pub><pmid>9282935</pmid><doi>10.1046/j.1471-4159.1997.69031131.x</doi><tpages>7</tpages></addata></record> |
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| subjects | Acetylcholine - metabolism Adenylyl Cyclases - metabolism Animals Arachidonic Acids - pharmacology Biological and medical sciences Cannabinoid receptor Cannabinoids - antagonists & inhibitors Cannabinoids - pharmacology Cerebral Cortex - drug effects Cerebral Cortex - physiology Corpus Striatum - drug effects Corpus Striatum - physiology Cyclic AMP Cyclic AMP - metabolism Cyclohexanols - pharmacology Dopamine Dopamine - metabolism Drug addictions Electric Stimulation Endocannabinoids In Vitro Techniques Kinetics Male Medical sciences Phosphatidylinositols - metabolism Piperidines - pharmacology Polyunsaturated Alkamides Potassium Chloride - pharmacology Pyrazoles - pharmacology Rat Rats Rats, Wistar Receptors, Cannabinoid Receptors, Drug - agonists Receptors, Drug - physiology Rimonabant Second Messenger Systems - drug effects Second Messenger Systems - physiology Striatum Toxicology |
| title | Influence of Cannabinoids on Electrically Evoked Dopamine Release and Cyclic AMP Generation in the Rat Striatum |
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