p107 and p130 Associated Cyclin A Has Altered Substrate Specificity

We demonstrate that p107 and p130 immune complexes exhibit kinase activity. We have tested such immune complexes with four substrates commonly utilized to assay Cdk activity, including all three known members of the retinoblastoma family. Immunodepletion revealed this kinase activity could be abolis...

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Veröffentlicht in:	The Journal of biological chemistry 1997-09, Vol.272 (36), p.22954-22959
Hauptverfasser:	Hauser, Paul J., Agrawal, Deepak, Chu, Baoky, Pledger, W.J.
Format:	Artikel
Sprache:	eng
Schlagworte:	3T3 Cells Animals Cyclins - metabolism Mice Mice, Inbred BALB C Nuclear Proteins - metabolism Phosphoproteins - metabolism Phosphorylation Protein Kinases - metabolism Proteins Retinoblastoma Protein - metabolism Retinoblastoma-Like Protein p107 Retinoblastoma-Like Protein p130 Substrate Specificity
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