A Generalised Increase in Protein Carbonyls in the Brain in Parkinson's but Not Incidental Lewy Body Disease

: The degeneration of neurones in Parkinson's disease (PD) may involve oxidative stress. Previously, increased lipid peroxidation and oxidative DNA damage have been reported in parkinsonian substantia nigra. In the present study the protein carbonyl assay was used to assess oxidative protein da...

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Veröffentlicht in:	Journal of neurochemistry 1997-09, Vol.69 (3), p.1326-1329
Hauptverfasser:	Alam, Zafar I., Daniel, Susan E., Lees, Andrew J., Marsden, David C., Jenner, Peter, Halliwell, Barry
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Aged, 80 and over Autopsy Biological and medical sciences Brain - metabolism Brain - pathology Brain Chemistry Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases Humans Incidental Lewy body disease Ketones - analysis Ketones - metabolism Medical sciences Middle Aged Nerve Degeneration Neurology Neurons - chemistry Neurons - metabolism Neurons - pathology Organ Specificity Oxidative damage Parkinson Disease - classification Parkinson Disease - metabolism Parkinson Disease - pathology Parkinson's disease Protein carbonyls Proteins - analysis Proteins - metabolism Reference Values Regression Analysis
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