Elevated platelet factor 4 and β-thromboglobulin plasma levels in depressed patients with ischemic heart disease
Clinical depression has recently been recognized as an independent risk factor for cardiac mortality in patients after myocardial infarction. The underlying mechanisms of this increased mortality remain unclear. This study investigated the hypothesis that patients suffering from ischemic heart disea...
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| Veröffentlicht in: | Biological psychiatry (1969) 1997-08, Vol.42 (4), p.290-295 |
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| container_title | Biological psychiatry (1969) |
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| creator | Laghrissi-Thode, Fouzia Wagner, William R. Pollock, Bruce G. Johnson, Peter C. Finkel, Mitchell S. |
| description | Clinical depression has recently been recognized as an independent risk factor for cardiac mortality in patients after myocardial infarction. The underlying mechanisms of this increased mortality remain unclear. This study investigated the hypothesis that patients suffering from ischemic heart disease (IHD) and depression concurrently may have abnormal platelet activation resulting in an increased risk of thrombosis. Platelet factor 4 (PF4) and
β-thromboglobulin (
β-TG) were measured in young healthy control subjects, in nondepressed patients with IHD, and in depressed patients with IHD. Mean PF4 and
β-TG plasma levels in the IHD group with depression were found to be significantly higher than those of the control and IHD groups. This increase was not related to age, gender, racial difference, aspirin use, or severity of cardiac disease. This finding suggests that in depressed patients with IHD there is greater platelet activation, and may indicate an increased risk of thrombotic complications. |
| doi_str_mv | 10.1016/S0006-3223(96)00345-9 |
| format | Article |
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β-thromboglobulin (
β-TG) were measured in young healthy control subjects, in nondepressed patients with IHD, and in depressed patients with IHD. Mean PF4 and
β-TG plasma levels in the IHD group with depression were found to be significantly higher than those of the control and IHD groups. This increase was not related to age, gender, racial difference, aspirin use, or severity of cardiac disease. This finding suggests that in depressed patients with IHD there is greater platelet activation, and may indicate an increased risk of thrombotic complications.</description><identifier>ISSN: 0006-3223</identifier><identifier>EISSN: 1873-2402</identifier><identifier>DOI: 10.1016/S0006-3223(96)00345-9</identifier><identifier>PMID: 9270907</identifier><identifier>CODEN: BIPCBF</identifier><language>eng</language><publisher>New York, NY: Elsevier Inc</publisher><subject>Adult ; Adult and adolescent clinical studies ; beta-Thromboglobulin - metabolism ; Biological and medical sciences ; Depression ; Depressive Disorder - blood ; Depressive Disorder - complications ; Female ; Humans ; ischemic heart disease ; Male ; Medical sciences ; Middle Aged ; Mood disorders ; Myocardial Ischemia - blood ; Myocardial Ischemia - complications ; Platelet factor 4 ; Platelet Factor 4 - metabolism ; Psychology. Psychoanalysis. Psychiatry ; Psychopathology. Psychiatry ; Risk Factors ; Thrombosis - blood ; β-thromglobulin</subject><ispartof>Biological psychiatry (1969), 1997-08, Vol.42 (4), p.290-295</ispartof><rights>1997 Society of Biological Psychiatry</rights><rights>1997 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c389t-81767efa5f66de646aa96c8901e22c141fc1afa469d52fd5e29911a9035e6c3a3</citedby><cites>FETCH-LOGICAL-c389t-81767efa5f66de646aa96c8901e22c141fc1afa469d52fd5e29911a9035e6c3a3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/S0006-3223(96)00345-9$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=2786622$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/9270907$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Laghrissi-Thode, Fouzia</creatorcontrib><creatorcontrib>Wagner, William R.</creatorcontrib><creatorcontrib>Pollock, Bruce G.</creatorcontrib><creatorcontrib>Johnson, Peter C.</creatorcontrib><creatorcontrib>Finkel, Mitchell S.</creatorcontrib><title>Elevated platelet factor 4 and β-thromboglobulin plasma levels in depressed patients with ischemic heart disease</title><title>Biological psychiatry (1969)</title><addtitle>Biol Psychiatry</addtitle><description>Clinical depression has recently been recognized as an independent risk factor for cardiac mortality in patients after myocardial infarction. The underlying mechanisms of this increased mortality remain unclear. This study investigated the hypothesis that patients suffering from ischemic heart disease (IHD) and depression concurrently may have abnormal platelet activation resulting in an increased risk of thrombosis. Platelet factor 4 (PF4) and
β-thromboglobulin (
β-TG) were measured in young healthy control subjects, in nondepressed patients with IHD, and in depressed patients with IHD. Mean PF4 and
β-TG plasma levels in the IHD group with depression were found to be significantly higher than those of the control and IHD groups. This increase was not related to age, gender, racial difference, aspirin use, or severity of cardiac disease. This finding suggests that in depressed patients with IHD there is greater platelet activation, and may indicate an increased risk of thrombotic complications.</description><subject>Adult</subject><subject>Adult and adolescent clinical studies</subject><subject>beta-Thromboglobulin - metabolism</subject><subject>Biological and medical sciences</subject><subject>Depression</subject><subject>Depressive Disorder - blood</subject><subject>Depressive Disorder - complications</subject><subject>Female</subject><subject>Humans</subject><subject>ischemic heart disease</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Mood disorders</subject><subject>Myocardial Ischemia - blood</subject><subject>Myocardial Ischemia - complications</subject><subject>Platelet factor 4</subject><subject>Platelet Factor 4 - metabolism</subject><subject>Psychology. Psychoanalysis. Psychiatry</subject><subject>Psychopathology. Psychiatry</subject><subject>Risk Factors</subject><subject>Thrombosis - blood</subject><subject>β-thromglobulin</subject><issn>0006-3223</issn><issn>1873-2402</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1997</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkM-KFDEQh4Mo6zj6CAs5iOihNUl3pzsnWZb1Dyx4UM-hJqk4kXT3bCqz4mv5ID6TmZ1hrp6KpL5fVfExdinFWymkfvdVCKGbVqn2tdFvhGi7vjGP2EqOQ9uoTqjHbHVGnrJnRD_rc1BKXrALowZhxLBidzcJ76Gg57tUS8LCA7iyZN5xmD3_-6cp27xMm-VHWjb7FOcDSBPwmsNEvH543GUkOsyAEnEuxH_FsuWR3Ban6PgWIRfuIyEQPmdPAiTCF6e6Zt8_3Hy7_tTcfvn4-frqtnHtaEozykEPGKAPWnvUnQYw2o1GSFTKyU4GJyFAp43vVfA9KmOkBCPaHrVroV2zV8e5u7zc7ZGKnepBmBLMuOzJDkZ1vRz6CvZH0OWFKGOwuxwnyL-tFPag2j6otgeP1mj7oNqamrs8LdhvJvTn1Mlt7b889YEcpJBhdpHOmBpGrevINXt_xKpNvI-YLbkq0aGPGV2xfon_OeQfAoycvw</recordid><startdate>19970815</startdate><enddate>19970815</enddate><creator>Laghrissi-Thode, Fouzia</creator><creator>Wagner, William R.</creator><creator>Pollock, Bruce G.</creator><creator>Johnson, Peter C.</creator><creator>Finkel, Mitchell S.</creator><general>Elsevier Inc</general><general>Elsevier Science</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19970815</creationdate><title>Elevated platelet factor 4 and β-thromboglobulin plasma levels in depressed patients with ischemic heart disease</title><author>Laghrissi-Thode, Fouzia ; Wagner, William R. ; Pollock, Bruce G. ; Johnson, Peter C. ; Finkel, Mitchell S.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c389t-81767efa5f66de646aa96c8901e22c141fc1afa469d52fd5e29911a9035e6c3a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1997</creationdate><topic>Adult</topic><topic>Adult and adolescent clinical studies</topic><topic>beta-Thromboglobulin - metabolism</topic><topic>Biological and medical sciences</topic><topic>Depression</topic><topic>Depressive Disorder - blood</topic><topic>Depressive Disorder - complications</topic><topic>Female</topic><topic>Humans</topic><topic>ischemic heart disease</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Mood disorders</topic><topic>Myocardial Ischemia - blood</topic><topic>Myocardial Ischemia - complications</topic><topic>Platelet factor 4</topic><topic>Platelet Factor 4 - metabolism</topic><topic>Psychology. Psychoanalysis. Psychiatry</topic><topic>Psychopathology. Psychiatry</topic><topic>Risk Factors</topic><topic>Thrombosis - blood</topic><topic>β-thromglobulin</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Laghrissi-Thode, Fouzia</creatorcontrib><creatorcontrib>Wagner, William R.</creatorcontrib><creatorcontrib>Pollock, Bruce G.</creatorcontrib><creatorcontrib>Johnson, Peter C.</creatorcontrib><creatorcontrib>Finkel, Mitchell S.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Biological psychiatry (1969)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Laghrissi-Thode, Fouzia</au><au>Wagner, William R.</au><au>Pollock, Bruce G.</au><au>Johnson, Peter C.</au><au>Finkel, Mitchell S.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Elevated platelet factor 4 and β-thromboglobulin plasma levels in depressed patients with ischemic heart disease</atitle><jtitle>Biological psychiatry (1969)</jtitle><addtitle>Biol Psychiatry</addtitle><date>1997-08-15</date><risdate>1997</risdate><volume>42</volume><issue>4</issue><spage>290</spage><epage>295</epage><pages>290-295</pages><issn>0006-3223</issn><eissn>1873-2402</eissn><coden>BIPCBF</coden><abstract>Clinical depression has recently been recognized as an independent risk factor for cardiac mortality in patients after myocardial infarction. The underlying mechanisms of this increased mortality remain unclear. This study investigated the hypothesis that patients suffering from ischemic heart disease (IHD) and depression concurrently may have abnormal platelet activation resulting in an increased risk of thrombosis. Platelet factor 4 (PF4) and
β-thromboglobulin (
β-TG) were measured in young healthy control subjects, in nondepressed patients with IHD, and in depressed patients with IHD. Mean PF4 and
β-TG plasma levels in the IHD group with depression were found to be significantly higher than those of the control and IHD groups. This increase was not related to age, gender, racial difference, aspirin use, or severity of cardiac disease. This finding suggests that in depressed patients with IHD there is greater platelet activation, and may indicate an increased risk of thrombotic complications.</abstract><cop>New York, NY</cop><pub>Elsevier Inc</pub><pmid>9270907</pmid><doi>10.1016/S0006-3223(96)00345-9</doi><tpages>6</tpages></addata></record> |
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| subjects | Adult Adult and adolescent clinical studies beta-Thromboglobulin - metabolism Biological and medical sciences Depression Depressive Disorder - blood Depressive Disorder - complications Female Humans ischemic heart disease Male Medical sciences Middle Aged Mood disorders Myocardial Ischemia - blood Myocardial Ischemia - complications Platelet factor 4 Platelet Factor 4 - metabolism Psychology. Psychoanalysis. Psychiatry Psychopathology. Psychiatry Risk Factors Thrombosis - blood β-thromglobulin |
| title | Elevated platelet factor 4 and β-thromboglobulin plasma levels in depressed patients with ischemic heart disease |
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