Ascorbate in healthy subjects, amyotrophic lateral sclerosis and Alzheimer's disease
The aim of the present study was to report the levels of ascorbic acid in amyotrophic lateral sclerosis (ALS) and Alzheimer's disease (AD) and the effectiveness of ascorbic acid homeostasis in the central nervous system. Plasma and CSF ascorbic acid levels were measured by high performance liqu...
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| Veröffentlicht in: | Acta neurologica Scandinavica 1997-08, Vol.96 (2), p.88-90 |
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| container_title | Acta neurologica Scandinavica |
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| creator | Paraskevas, G. P. Kapaki, E. Libitaki, G. Zournas, C. Segditsa, I. Papageorgiou, C. |
| description | The aim of the present study was to report the levels of ascorbic acid in amyotrophic lateral sclerosis (ALS) and Alzheimer's disease (AD) and the effectiveness of ascorbic acid homeostasis in the central nervous system. Plasma and CSF ascorbic acid levels were measured by high performance liquid chromatography in 19 ALS patients, 17 AD patients and 15 controls. No statistically significant difference was found between patients and controls. However, wide fluctuations of plasma concentrations were found to result in relatively stable CSF levels, by appropriate adjustments of CSF/ plasma ratio. It appears that in normal subjects and in the diseases under study, this ratio reflects the activity of the choroid plexus ascorbate transporter. |
| doi_str_mv | 10.1111/j.1600-0404.1997.tb00245.x |
| format | Article |
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P. ; Kapaki, E. ; Libitaki, G. ; Zournas, C. ; Segditsa, I. ; Papageorgiou, C.</creator><creatorcontrib>Paraskevas, G. P. ; Kapaki, E. ; Libitaki, G. ; Zournas, C. ; Segditsa, I. ; Papageorgiou, C.</creatorcontrib><description>The aim of the present study was to report the levels of ascorbic acid in amyotrophic lateral sclerosis (ALS) and Alzheimer's disease (AD) and the effectiveness of ascorbic acid homeostasis in the central nervous system. Plasma and CSF ascorbic acid levels were measured by high performance liquid chromatography in 19 ALS patients, 17 AD patients and 15 controls. No statistically significant difference was found between patients and controls. However, wide fluctuations of plasma concentrations were found to result in relatively stable CSF levels, by appropriate adjustments of CSF/ plasma ratio. It appears that in normal subjects and in the diseases under study, this ratio reflects the activity of the choroid plexus ascorbate transporter.</description><identifier>ISSN: 0001-6314</identifier><identifier>EISSN: 1600-0404</identifier><identifier>DOI: 10.1111/j.1600-0404.1997.tb00245.x</identifier><identifier>PMID: 9272183</identifier><identifier>CODEN: ANRSAS</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Publishing Ltd</publisher><subject>Alzheimer Disease - blood ; Alzheimer Disease - cerebrospinal fluid ; Alzheimer's disease ; amyotrophic lateral sclerosis ; Amyotrophic Lateral Sclerosis - blood ; Amyotrophic Lateral Sclerosis - cerebrospinal fluid ; Analysis of Variance ; antioxidants ; ascorbic acid ; Ascorbic Acid - blood ; Ascorbic Acid - cerebrospinal fluid ; Biological and medical sciences ; Biomarkers - blood ; Biomarkers - cerebrospinal fluid ; Case-Control Studies ; Chi-Square Distribution ; Degenerative and inherited degenerative diseases of the nervous system. 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Prion diseases ; Female ; Homeostasis - physiology ; Humans ; Least-Squares Analysis ; Male ; Medical sciences ; Middle Aged ; Neurology ; oxidative stress</subject><ispartof>Acta neurologica Scandinavica, 1997-08, Vol.96 (2), p.88-90</ispartof><rights>1997 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c5538-985290d4ccf28124a52f145ef9a957eddfbbd3c8724ca698fd8fba388e9d8fcf3</citedby><cites>FETCH-LOGICAL-c5538-985290d4ccf28124a52f145ef9a957eddfbbd3c8724ca698fd8fba388e9d8fcf3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fj.1600-0404.1997.tb00245.x$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fj.1600-0404.1997.tb00245.x$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=2764847$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/9272183$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Paraskevas, G. P.</creatorcontrib><creatorcontrib>Kapaki, E.</creatorcontrib><creatorcontrib>Libitaki, G.</creatorcontrib><creatorcontrib>Zournas, C.</creatorcontrib><creatorcontrib>Segditsa, I.</creatorcontrib><creatorcontrib>Papageorgiou, C.</creatorcontrib><title>Ascorbate in healthy subjects, amyotrophic lateral sclerosis and Alzheimer's disease</title><title>Acta neurologica Scandinavica</title><addtitle>Acta Neurol Scand</addtitle><description>The aim of the present study was to report the levels of ascorbic acid in amyotrophic lateral sclerosis (ALS) and Alzheimer's disease (AD) and the effectiveness of ascorbic acid homeostasis in the central nervous system. Plasma and CSF ascorbic acid levels were measured by high performance liquid chromatography in 19 ALS patients, 17 AD patients and 15 controls. No statistically significant difference was found between patients and controls. However, wide fluctuations of plasma concentrations were found to result in relatively stable CSF levels, by appropriate adjustments of CSF/ plasma ratio. It appears that in normal subjects and in the diseases under study, this ratio reflects the activity of the choroid plexus ascorbate transporter.</description><subject>Alzheimer Disease - blood</subject><subject>Alzheimer Disease - cerebrospinal fluid</subject><subject>Alzheimer's disease</subject><subject>amyotrophic lateral sclerosis</subject><subject>Amyotrophic Lateral Sclerosis - blood</subject><subject>Amyotrophic Lateral Sclerosis - cerebrospinal fluid</subject><subject>Analysis of Variance</subject><subject>antioxidants</subject><subject>ascorbic acid</subject><subject>Ascorbic Acid - blood</subject><subject>Ascorbic Acid - cerebrospinal fluid</subject><subject>Biological and medical sciences</subject><subject>Biomarkers - blood</subject><subject>Biomarkers - cerebrospinal fluid</subject><subject>Case-Control Studies</subject><subject>Chi-Square Distribution</subject><subject>Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases</subject><subject>Female</subject><subject>Homeostasis - physiology</subject><subject>Humans</subject><subject>Least-Squares Analysis</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Neurology</subject><subject>oxidative stress</subject><issn>0001-6314</issn><issn>1600-0404</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1997</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqVkNGOEyEUhonRrHX1EUyIMXrjjMDAACZeNJvd1WSzmrjqJWEYSKlMp3KmsfXppemk93ID5Hz_4fAh9IqSmpb1fl3TlpCKcMJrqrWsp44QxkW9f4QW59JjtCCE0KptKH-KngGsy41Jzi_QhWaSUdUs0MMS3Jg7O3kcN3jlbZpWBwy7bu3dBO-wHQ7jlMftKjqcCpVtwuCSzyNEwHbT42X6u_Jx8Pkt4D6Ct-CfoyfBJvAv5v0Sfb-5frj6VN19uf18tbyrnBCNqrQSTJOeOxeYooxbwQLlwgdttZC-70PX9Y1TknFnW61Cr0JnG6W8LicXmkv05tR3m8ffOw-TGSI4n5Ld-HEHRmrGeflzAT-cQFfmhuyD2eY42HwwlJijUrM2R2_m6M0clZpZqdmX8Mv5lV03-P4cnR2W-uu5bsHZFLLduAhnjMmWKy4L9vGE_YnJH_5jALO8v1aq5KtTPsLk9-e8zb9MKxspzM_7W_PjK-HsRnwzovkH6eejDQ</recordid><startdate>199708</startdate><enddate>199708</enddate><creator>Paraskevas, G. P.</creator><creator>Kapaki, E.</creator><creator>Libitaki, G.</creator><creator>Zournas, C.</creator><creator>Segditsa, I.</creator><creator>Papageorgiou, C.</creator><general>Blackwell Publishing Ltd</general><general>Blackwell</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>199708</creationdate><title>Ascorbate in healthy subjects, amyotrophic lateral sclerosis and Alzheimer's disease</title><author>Paraskevas, G. P. ; Kapaki, E. ; Libitaki, G. ; Zournas, C. ; Segditsa, I. ; Papageorgiou, C.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5538-985290d4ccf28124a52f145ef9a957eddfbbd3c8724ca698fd8fba388e9d8fcf3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1997</creationdate><topic>Alzheimer Disease - blood</topic><topic>Alzheimer Disease - cerebrospinal fluid</topic><topic>Alzheimer's disease</topic><topic>amyotrophic lateral sclerosis</topic><topic>Amyotrophic Lateral Sclerosis - blood</topic><topic>Amyotrophic Lateral Sclerosis - cerebrospinal fluid</topic><topic>Analysis of Variance</topic><topic>antioxidants</topic><topic>ascorbic acid</topic><topic>Ascorbic Acid - blood</topic><topic>Ascorbic Acid - cerebrospinal fluid</topic><topic>Biological and medical sciences</topic><topic>Biomarkers - blood</topic><topic>Biomarkers - cerebrospinal fluid</topic><topic>Case-Control Studies</topic><topic>Chi-Square Distribution</topic><topic>Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases</topic><topic>Female</topic><topic>Homeostasis - physiology</topic><topic>Humans</topic><topic>Least-Squares Analysis</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Neurology</topic><topic>oxidative stress</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Paraskevas, G. 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P.</au><au>Kapaki, E.</au><au>Libitaki, G.</au><au>Zournas, C.</au><au>Segditsa, I.</au><au>Papageorgiou, C.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Ascorbate in healthy subjects, amyotrophic lateral sclerosis and Alzheimer's disease</atitle><jtitle>Acta neurologica Scandinavica</jtitle><addtitle>Acta Neurol Scand</addtitle><date>1997-08</date><risdate>1997</risdate><volume>96</volume><issue>2</issue><spage>88</spage><epage>90</epage><pages>88-90</pages><issn>0001-6314</issn><eissn>1600-0404</eissn><coden>ANRSAS</coden><abstract>The aim of the present study was to report the levels of ascorbic acid in amyotrophic lateral sclerosis (ALS) and Alzheimer's disease (AD) and the effectiveness of ascorbic acid homeostasis in the central nervous system. Plasma and CSF ascorbic acid levels were measured by high performance liquid chromatography in 19 ALS patients, 17 AD patients and 15 controls. 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| source | MEDLINE; Wiley Online Library Journals Frontfile Complete |
| subjects | Alzheimer Disease - blood Alzheimer Disease - cerebrospinal fluid Alzheimer's disease amyotrophic lateral sclerosis Amyotrophic Lateral Sclerosis - blood Amyotrophic Lateral Sclerosis - cerebrospinal fluid Analysis of Variance antioxidants ascorbic acid Ascorbic Acid - blood Ascorbic Acid - cerebrospinal fluid Biological and medical sciences Biomarkers - blood Biomarkers - cerebrospinal fluid Case-Control Studies Chi-Square Distribution Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases Female Homeostasis - physiology Humans Least-Squares Analysis Male Medical sciences Middle Aged Neurology oxidative stress |
| title | Ascorbate in healthy subjects, amyotrophic lateral sclerosis and Alzheimer's disease |
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