Influence of hydrocortisone acetate administered to the lactating rat on lipid composition of the milk and serum lipid levels in dams and pups
Summary The influence of i. m. administration of hydrocortisone acetate to the mother (doses of 0.4, 0.8 or 2 mg/100 g body weight/day) during the first 15 days of lactation on milk composition in fatty acids mother and pups serum levels of lipids and their effect on pups' growth is studied. Se...
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| Veröffentlicht in: | Hormone and metabolic research 1989-08, Vol.21 (8), p.421-426 |
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| creator | Llopis, J Lampreabe, A Peran, F Mataix, F.J Urbano, G Montellano, M.A |
| description | Summary
The influence of i. m. administration of hydrocortisone acetate to the mother (doses of 0.4, 0.8 or 2 mg/100 g body weight/day) during the first 15 days of lactation on milk composition in fatty acids mother and pups serum levels of lipids and their effect on pups' growth is studied.
Serum levels of cholesterol and triglycerides in mothers increase at any of the experimental doses.
Daily injections of 2 mg/100 g bw to the mother cause an increase in the percentage of C16 as well as in the level of fatty acids derived from linoleic and linolenic acids while reducing the percentage of C18:1.
The treatment brings about a higher level in total lipids in the milk which is proportional to the dose. Doses of 0.4 and 0.8 mg increase the percentage of C8 and C10, while the dose of 2 mg enhances the % of C16. A fall in the uptake of linoleic acid by the mammary gland is observed when using any of the experimental doses.
No change is observed either in the weight of pups or in serum cholesterol levels while triglyceride level is increased by the effect of treatment. The higher dose increases the level of linolenic acid and some of its derivates. |
| doi_str_mv | 10.1055/s-2007-1009252 |
| format | Article |
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The influence of i. m. administration of hydrocortisone acetate to the mother (doses of 0.4, 0.8 or 2 mg/100 g body weight/day) during the first 15 days of lactation on milk composition in fatty acids mother and pups serum levels of lipids and their effect on pups' growth is studied.
Serum levels of cholesterol and triglycerides in mothers increase at any of the experimental doses.
Daily injections of 2 mg/100 g bw to the mother cause an increase in the percentage of C16 as well as in the level of fatty acids derived from linoleic and linolenic acids while reducing the percentage of C18:1.
The treatment brings about a higher level in total lipids in the milk which is proportional to the dose. Doses of 0.4 and 0.8 mg increase the percentage of C8 and C10, while the dose of 2 mg enhances the % of C16. A fall in the uptake of linoleic acid by the mammary gland is observed when using any of the experimental doses.
No change is observed either in the weight of pups or in serum cholesterol levels while triglyceride level is increased by the effect of treatment. The higher dose increases the level of linolenic acid and some of its derivates.</description><identifier>ISSN: 0018-5043</identifier><identifier>EISSN: 1439-4286</identifier><identifier>DOI: 10.1055/s-2007-1009252</identifier><identifier>PMID: 2793064</identifier><identifier>CODEN: HMMRA2</identifier><language>eng</language><publisher>Stuttgart: Thieme</publisher><subject>Animals ; Animals, Suckling - metabolism ; Biological and medical sciences ; blood serum ; Caseins - biosynthesis ; Cholesterol - blood ; cortisol ; dams (mothers) ; Fatty Acids - blood ; Female ; Fundamental and applied biological sciences. Psychology ; Hydrocortisone - blood ; Hydrocortisone - pharmacology ; Lactation ; lipid content ; Lipid Metabolism ; Lipids - blood ; Lipids. Glycolipids ; Metabolisms and neurohumoral controls ; Milk - drug effects ; Milk - metabolism ; milk composition ; Originals Basic ; Pregnancy ; pups ; Radioimmunoassay ; Rats ; Rats, Inbred Strains ; Triglycerides - blood ; Vertebrates: anatomy and physiology, studies on body, several organs or systems</subject><ispartof>Hormone and metabolic research, 1989-08, Vol.21 (8), p.421-426</ispartof><rights>Georg Thieme Verlag, Stuttgart · New York</rights><rights>1990 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c381t-3f8d841946de42a7bf56308291f4b2a6a157742b9e65f5d19b3e2f7aaff5c1da3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.thieme-connect.de/products/ejournals/pdf/10.1055/s-2007-1009252.pdf$$EPDF$$P50$$Gthieme$$H</linktopdf><link.rule.ids>314,776,780,3003,3004,27902,27903,54536</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=6656273$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/2793064$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Llopis, J</creatorcontrib><creatorcontrib>Lampreabe, A</creatorcontrib><creatorcontrib>Peran, F</creatorcontrib><creatorcontrib>Mataix, F.J</creatorcontrib><creatorcontrib>Urbano, G</creatorcontrib><creatorcontrib>Montellano, M.A</creatorcontrib><title>Influence of hydrocortisone acetate administered to the lactating rat on lipid composition of the milk and serum lipid levels in dams and pups</title><title>Hormone and metabolic research</title><addtitle>Horm Metab Res</addtitle><description>Summary
The influence of i. m. administration of hydrocortisone acetate to the mother (doses of 0.4, 0.8 or 2 mg/100 g body weight/day) during the first 15 days of lactation on milk composition in fatty acids mother and pups serum levels of lipids and their effect on pups' growth is studied.
Serum levels of cholesterol and triglycerides in mothers increase at any of the experimental doses.
Daily injections of 2 mg/100 g bw to the mother cause an increase in the percentage of C16 as well as in the level of fatty acids derived from linoleic and linolenic acids while reducing the percentage of C18:1.
The treatment brings about a higher level in total lipids in the milk which is proportional to the dose. Doses of 0.4 and 0.8 mg increase the percentage of C8 and C10, while the dose of 2 mg enhances the % of C16. A fall in the uptake of linoleic acid by the mammary gland is observed when using any of the experimental doses.
No change is observed either in the weight of pups or in serum cholesterol levels while triglyceride level is increased by the effect of treatment. The higher dose increases the level of linolenic acid and some of its derivates.</description><subject>Animals</subject><subject>Animals, Suckling - metabolism</subject><subject>Biological and medical sciences</subject><subject>blood serum</subject><subject>Caseins - biosynthesis</subject><subject>Cholesterol - blood</subject><subject>cortisol</subject><subject>dams (mothers)</subject><subject>Fatty Acids - blood</subject><subject>Female</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Hydrocortisone - blood</subject><subject>Hydrocortisone - pharmacology</subject><subject>Lactation</subject><subject>lipid content</subject><subject>Lipid Metabolism</subject><subject>Lipids - blood</subject><subject>Lipids. Glycolipids</subject><subject>Metabolisms and neurohumoral controls</subject><subject>Milk - drug effects</subject><subject>Milk - metabolism</subject><subject>milk composition</subject><subject>Originals Basic</subject><subject>Pregnancy</subject><subject>pups</subject><subject>Radioimmunoassay</subject><subject>Rats</subject><subject>Rats, Inbred Strains</subject><subject>Triglycerides - blood</subject><subject>Vertebrates: anatomy and physiology, studies on body, several organs or systems</subject><issn>0018-5043</issn><issn>1439-4286</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1989</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kU9v1DAQxS0EKtvClRvCB8Qtxf-THFEFtFIlDtBz5LXHXRfHDraD1C_BZ8bLRr1xGs2837yR5iH0hpJLSqT8WDpGSN9RQkYm2TO0o4KPnWCDeo52hNChk0Twl-i8lIfWipGKM3TG-pETJXboz010YYVoACeHD482J5Ny9SVFwNpA1bVVO_voS4UMFteE6wFw0KZpPt7jrCtOEQe_eItNmpdUfPVt0gyP5OzDT6yjxQXyOm9cgN8QCvYRWz2Xf_KyLuUVeuF0KPB6qxfo7svnH1fX3e23rzdXn247wwdaO-4GOwg6CmVBMN3vnVScDGykTuyZVprKvhdsP4KSTlo67jkw12vtnDTUan6BPpx8l5x-rVDqNPtiIAQdIa1l6kcmqJC0gZcn0ORUSgY3LdnPOj9OlEzHAKYyHQOYtgDawtvNed3PYJ_w7eNNf7_puhgdXNbR-PKEKSUV63nDuhNWDx5mmB7SmmP7yP_PvjvxTqdJ3-dmefedEcoJU70aGOV_AXWPpuY</recordid><startdate>19890801</startdate><enddate>19890801</enddate><creator>Llopis, J</creator><creator>Lampreabe, A</creator><creator>Peran, F</creator><creator>Mataix, F.J</creator><creator>Urbano, G</creator><creator>Montellano, M.A</creator><general>Thieme</general><scope>FBQ</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19890801</creationdate><title>Influence of hydrocortisone acetate administered to the lactating rat on lipid composition of the milk and serum lipid levels in dams and pups</title><author>Llopis, J ; Lampreabe, A ; Peran, F ; Mataix, F.J ; Urbano, G ; Montellano, M.A</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c381t-3f8d841946de42a7bf56308291f4b2a6a157742b9e65f5d19b3e2f7aaff5c1da3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1989</creationdate><topic>Animals</topic><topic>Animals, Suckling - metabolism</topic><topic>Biological and medical sciences</topic><topic>blood serum</topic><topic>Caseins - biosynthesis</topic><topic>Cholesterol - blood</topic><topic>cortisol</topic><topic>dams (mothers)</topic><topic>Fatty Acids - blood</topic><topic>Female</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Hydrocortisone - blood</topic><topic>Hydrocortisone - pharmacology</topic><topic>Lactation</topic><topic>lipid content</topic><topic>Lipid Metabolism</topic><topic>Lipids - blood</topic><topic>Lipids. Glycolipids</topic><topic>Metabolisms and neurohumoral controls</topic><topic>Milk - drug effects</topic><topic>Milk - metabolism</topic><topic>milk composition</topic><topic>Originals Basic</topic><topic>Pregnancy</topic><topic>pups</topic><topic>Radioimmunoassay</topic><topic>Rats</topic><topic>Rats, Inbred Strains</topic><topic>Triglycerides - blood</topic><topic>Vertebrates: anatomy and physiology, studies on body, several organs or systems</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Llopis, J</creatorcontrib><creatorcontrib>Lampreabe, A</creatorcontrib><creatorcontrib>Peran, F</creatorcontrib><creatorcontrib>Mataix, F.J</creatorcontrib><creatorcontrib>Urbano, G</creatorcontrib><creatorcontrib>Montellano, M.A</creatorcontrib><collection>AGRIS</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Hormone and metabolic research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Llopis, J</au><au>Lampreabe, A</au><au>Peran, F</au><au>Mataix, F.J</au><au>Urbano, G</au><au>Montellano, M.A</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Influence of hydrocortisone acetate administered to the lactating rat on lipid composition of the milk and serum lipid levels in dams and pups</atitle><jtitle>Hormone and metabolic research</jtitle><addtitle>Horm Metab Res</addtitle><date>1989-08-01</date><risdate>1989</risdate><volume>21</volume><issue>8</issue><spage>421</spage><epage>426</epage><pages>421-426</pages><issn>0018-5043</issn><eissn>1439-4286</eissn><coden>HMMRA2</coden><abstract>Summary
The influence of i. m. administration of hydrocortisone acetate to the mother (doses of 0.4, 0.8 or 2 mg/100 g body weight/day) during the first 15 days of lactation on milk composition in fatty acids mother and pups serum levels of lipids and their effect on pups' growth is studied.
Serum levels of cholesterol and triglycerides in mothers increase at any of the experimental doses.
Daily injections of 2 mg/100 g bw to the mother cause an increase in the percentage of C16 as well as in the level of fatty acids derived from linoleic and linolenic acids while reducing the percentage of C18:1.
The treatment brings about a higher level in total lipids in the milk which is proportional to the dose. Doses of 0.4 and 0.8 mg increase the percentage of C8 and C10, while the dose of 2 mg enhances the % of C16. A fall in the uptake of linoleic acid by the mammary gland is observed when using any of the experimental doses.
No change is observed either in the weight of pups or in serum cholesterol levels while triglyceride level is increased by the effect of treatment. The higher dose increases the level of linolenic acid and some of its derivates.</abstract><cop>Stuttgart</cop><cop>New York, NY</cop><pub>Thieme</pub><pmid>2793064</pmid><doi>10.1055/s-2007-1009252</doi><tpages>6</tpages></addata></record> |
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| ispartof | Hormone and metabolic research, 1989-08, Vol.21 (8), p.421-426 |
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| source | MEDLINE; Thieme Connect Journals |
| subjects | Animals Animals, Suckling - metabolism Biological and medical sciences blood serum Caseins - biosynthesis Cholesterol - blood cortisol dams (mothers) Fatty Acids - blood Female Fundamental and applied biological sciences. Psychology Hydrocortisone - blood Hydrocortisone - pharmacology Lactation lipid content Lipid Metabolism Lipids - blood Lipids. Glycolipids Metabolisms and neurohumoral controls Milk - drug effects Milk - metabolism milk composition Originals Basic Pregnancy pups Radioimmunoassay Rats Rats, Inbred Strains Triglycerides - blood Vertebrates: anatomy and physiology, studies on body, several organs or systems |
| title | Influence of hydrocortisone acetate administered to the lactating rat on lipid composition of the milk and serum lipid levels in dams and pups |
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