α-Synuclein in Lewy bodies
Lewy bodies, a defining pathological characteristic of Parkinson's disease and dementia with Lewy bodies (DLB), constitute the second most common nerve cell pathology, after the neurofibrillary lesions of Alzheimer's disease. Their formation may cause neurodegeneration, but their biochemic...
Gespeichert in:
| Veröffentlicht in: | Nature (London) 1997-08, Vol.388 (6645), p.839-840 |
|---|---|
| Hauptverfasser: | , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 840 |
|---|---|
| container_issue | 6645 |
| container_start_page | 839 |
| container_title | Nature (London) |
| container_volume | 388 |
| creator | Spillantini, Maria Grazia Schmidt, Marie Luise Lee, Virginia M.-Y Trojanowski, John Q Jakes, Ross Goedert, Michel |
| description | Lewy bodies, a defining pathological characteristic of Parkinson's disease and dementia with Lewy bodies (DLB), constitute the second most common nerve cell pathology, after the neurofibrillary lesions of Alzheimer's disease. Their formation may cause neurodegeneration, but their biochemical composition is unknown. Neurofilaments and ubiquitin are present, but it is unclear whether they are major components of the filamentous material of the Lewy body,. Here we describe strong staining of Lewy bodies from idiopathic Parkinson's disease with antibodies for α-synuclein, a presynaptic protein of unknown function which is mutated in some familial cases of the disease. α-Synuclein may be the main component of the Lewy body in Parkinson's disease. We also show staining for α-synuclein of Lewy bodies from DLB, indicating that the Lewy bodies from these two diseases may have identical compositions. |
| doi_str_mv | 10.1038/42166 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_79240478</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>79240478</sourcerecordid><originalsourceid>FETCH-LOGICAL-c318t-37e04b3cea3effd8ddc07b434d4e2ab83aa22a5f9df6904ce601b2c627eb3203</originalsourceid><addsrcrecordid>eNqFkMtKw0AUhgdRaq19giJ0o7vomZnTmclSijcIuLD7MJcTiORSMw3Sx_JFfCajKd0KB87i__5_8TE253DLQZo7FFypEzblqFWCyuhTNgUQJgEj1Tm7iPEdAFZc44RNUqENIE7Z4vsreds3va-obJbDZfS5X7o2lBQv2Vlhq0jzw5-xzePDZv2cZK9PL-v7LPGSm10iNQE66clKKopgQvCgHUoMSMI6I60Vwq6KNBQqBfSkgDvhldDkpAA5Yzfj7LZrP3qKu7wuo6eqsg21fcx1KhBQm39BrkDI1PABvB5B37UxdlTk266sbbfPOeS_svI_WQN3dRjsXU3hSB3sDPlizBu76zs65mP7B0Qba10</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>16023981</pqid></control><display><type>article</type><title>α-Synuclein in Lewy bodies</title><source>MEDLINE</source><source>Nature</source><source>SpringerLink Journals - AutoHoldings</source><creator>Spillantini, Maria Grazia ; Schmidt, Marie Luise ; Lee, Virginia M.-Y ; Trojanowski, John Q ; Jakes, Ross ; Goedert, Michel</creator><creatorcontrib>Spillantini, Maria Grazia ; Schmidt, Marie Luise ; Lee, Virginia M.-Y ; Trojanowski, John Q ; Jakes, Ross ; Goedert, Michel</creatorcontrib><description>Lewy bodies, a defining pathological characteristic of Parkinson's disease and dementia with Lewy bodies (DLB), constitute the second most common nerve cell pathology, after the neurofibrillary lesions of Alzheimer's disease. Their formation may cause neurodegeneration, but their biochemical composition is unknown. Neurofilaments and ubiquitin are present, but it is unclear whether they are major components of the filamentous material of the Lewy body,. Here we describe strong staining of Lewy bodies from idiopathic Parkinson's disease with antibodies for α-synuclein, a presynaptic protein of unknown function which is mutated in some familial cases of the disease. α-Synuclein may be the main component of the Lewy body in Parkinson's disease. We also show staining for α-synuclein of Lewy bodies from DLB, indicating that the Lewy bodies from these two diseases may have identical compositions.</description><identifier>ISSN: 0028-0836</identifier><identifier>EISSN: 1476-4687</identifier><identifier>DOI: 10.1038/42166</identifier><identifier>PMID: 9278044</identifier><language>eng</language><publisher>England</publisher><subject>alpha-Synuclein ; Humans ; Immunohistochemistry ; Lewy Bodies - metabolism ; Nerve Tissue Proteins - analysis ; Parkinson Disease - metabolism ; Synucleins</subject><ispartof>Nature (London), 1997-08, Vol.388 (6645), p.839-840</ispartof><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/9278044$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Spillantini, Maria Grazia</creatorcontrib><creatorcontrib>Schmidt, Marie Luise</creatorcontrib><creatorcontrib>Lee, Virginia M.-Y</creatorcontrib><creatorcontrib>Trojanowski, John Q</creatorcontrib><creatorcontrib>Jakes, Ross</creatorcontrib><creatorcontrib>Goedert, Michel</creatorcontrib><title>α-Synuclein in Lewy bodies</title><title>Nature (London)</title><addtitle>Nature</addtitle><description>Lewy bodies, a defining pathological characteristic of Parkinson's disease and dementia with Lewy bodies (DLB), constitute the second most common nerve cell pathology, after the neurofibrillary lesions of Alzheimer's disease. Their formation may cause neurodegeneration, but their biochemical composition is unknown. Neurofilaments and ubiquitin are present, but it is unclear whether they are major components of the filamentous material of the Lewy body,. Here we describe strong staining of Lewy bodies from idiopathic Parkinson's disease with antibodies for α-synuclein, a presynaptic protein of unknown function which is mutated in some familial cases of the disease. α-Synuclein may be the main component of the Lewy body in Parkinson's disease. We also show staining for α-synuclein of Lewy bodies from DLB, indicating that the Lewy bodies from these two diseases may have identical compositions.</description><subject>alpha-Synuclein</subject><subject>Humans</subject><subject>Immunohistochemistry</subject><subject>Lewy Bodies - metabolism</subject><subject>Nerve Tissue Proteins - analysis</subject><subject>Parkinson Disease - metabolism</subject><subject>Synucleins</subject><issn>0028-0836</issn><issn>1476-4687</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1997</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkMtKw0AUhgdRaq19giJ0o7vomZnTmclSijcIuLD7MJcTiORSMw3Sx_JFfCajKd0KB87i__5_8TE253DLQZo7FFypEzblqFWCyuhTNgUQJgEj1Tm7iPEdAFZc44RNUqENIE7Z4vsreds3va-obJbDZfS5X7o2lBQv2Vlhq0jzw5-xzePDZv2cZK9PL-v7LPGSm10iNQE66clKKopgQvCgHUoMSMI6I60Vwq6KNBQqBfSkgDvhldDkpAA5Yzfj7LZrP3qKu7wuo6eqsg21fcx1KhBQm39BrkDI1PABvB5B37UxdlTk266sbbfPOeS_svI_WQN3dRjsXU3hSB3sDPlizBu76zs65mP7B0Qba10</recordid><startdate>19970828</startdate><enddate>19970828</enddate><creator>Spillantini, Maria Grazia</creator><creator>Schmidt, Marie Luise</creator><creator>Lee, Virginia M.-Y</creator><creator>Trojanowski, John Q</creator><creator>Jakes, Ross</creator><creator>Goedert, Michel</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>7X8</scope></search><sort><creationdate>19970828</creationdate><title>α-Synuclein in Lewy bodies</title><author>Spillantini, Maria Grazia ; Schmidt, Marie Luise ; Lee, Virginia M.-Y ; Trojanowski, John Q ; Jakes, Ross ; Goedert, Michel</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c318t-37e04b3cea3effd8ddc07b434d4e2ab83aa22a5f9df6904ce601b2c627eb3203</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1997</creationdate><topic>alpha-Synuclein</topic><topic>Humans</topic><topic>Immunohistochemistry</topic><topic>Lewy Bodies - metabolism</topic><topic>Nerve Tissue Proteins - analysis</topic><topic>Parkinson Disease - metabolism</topic><topic>Synucleins</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Spillantini, Maria Grazia</creatorcontrib><creatorcontrib>Schmidt, Marie Luise</creatorcontrib><creatorcontrib>Lee, Virginia M.-Y</creatorcontrib><creatorcontrib>Trojanowski, John Q</creatorcontrib><creatorcontrib>Jakes, Ross</creatorcontrib><creatorcontrib>Goedert, Michel</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Nature (London)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Spillantini, Maria Grazia</au><au>Schmidt, Marie Luise</au><au>Lee, Virginia M.-Y</au><au>Trojanowski, John Q</au><au>Jakes, Ross</au><au>Goedert, Michel</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>α-Synuclein in Lewy bodies</atitle><jtitle>Nature (London)</jtitle><addtitle>Nature</addtitle><date>1997-08-28</date><risdate>1997</risdate><volume>388</volume><issue>6645</issue><spage>839</spage><epage>840</epage><pages>839-840</pages><issn>0028-0836</issn><eissn>1476-4687</eissn><abstract>Lewy bodies, a defining pathological characteristic of Parkinson's disease and dementia with Lewy bodies (DLB), constitute the second most common nerve cell pathology, after the neurofibrillary lesions of Alzheimer's disease. Their formation may cause neurodegeneration, but their biochemical composition is unknown. Neurofilaments and ubiquitin are present, but it is unclear whether they are major components of the filamentous material of the Lewy body,. Here we describe strong staining of Lewy bodies from idiopathic Parkinson's disease with antibodies for α-synuclein, a presynaptic protein of unknown function which is mutated in some familial cases of the disease. α-Synuclein may be the main component of the Lewy body in Parkinson's disease. We also show staining for α-synuclein of Lewy bodies from DLB, indicating that the Lewy bodies from these two diseases may have identical compositions.</abstract><cop>England</cop><pmid>9278044</pmid><doi>10.1038/42166</doi><tpages>2</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0028-0836 |
| ispartof | Nature (London), 1997-08, Vol.388 (6645), p.839-840 |
| issn | 0028-0836 1476-4687 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_79240478 |
| source | MEDLINE; Nature; SpringerLink Journals - AutoHoldings |
| subjects | alpha-Synuclein Humans Immunohistochemistry Lewy Bodies - metabolism Nerve Tissue Proteins - analysis Parkinson Disease - metabolism Synucleins |
| title | α-Synuclein in Lewy bodies |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-03T11%3A21%3A13IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=%CE%B1-Synuclein%20in%20Lewy%20bodies&rft.jtitle=Nature%20(London)&rft.au=Spillantini,%20Maria%20Grazia&rft.date=1997-08-28&rft.volume=388&rft.issue=6645&rft.spage=839&rft.epage=840&rft.pages=839-840&rft.issn=0028-0836&rft.eissn=1476-4687&rft_id=info:doi/10.1038/42166&rft_dat=%3Cproquest_cross%3E79240478%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=16023981&rft_id=info:pmid/9278044&rfr_iscdi=true |