Quantitative Structure-Activity Relationship of Multidrug Resistance Reversal Agents

Multidrug resistance (MDR) is one of the major obstacles to long term successful cancer chemotherapy. The use of MDR reversal (MDRR) agents is a promising approach to overcome the undesired MDR phenotype. To design more effective MDRR agents that are urgently needed for clinical use, a data set of 6...

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Veröffentlicht in:	Molecular pharmacology 1997-08, Vol.52 (2), p.323-334
Hauptverfasser:	Klopman, G, Shi, L M, Ramu, A
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals ATP Binding Cassette Transporter, Subfamily B, Member 1 - antagonists & inhibitors Drug Design Drug Resistance, Multiple Drug Resistance, Neoplasm Humans Mice Paclitaxel - chemistry Structure-Activity Relationship
Online-Zugang:	Volltext
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