Worsening Left Ventricular Performance on Serial Exercise Radionuclide Angiography Does Not Identify High-Risk Patients
To determine whether worsening exercise performance on serial exercise radionuclide angiography identifies patients at increased risk of future cardiac events. One hundred nine medically treated patients with previous Q-wave myocardial infarction underwent two exercise radionuclide angiographic stud...
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| Veröffentlicht in: | Mayo Clinic proceedings 1997-08, Vol.72 (8), p.711-718 |
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| creator | Chaliki, Hari P. Miller, Todd D. Christian, Timothy F. Bailey, Kent R. Gibbons, Raymond J. |
| description | To determine whether worsening exercise performance on serial exercise radionuclide angiography identifies patients at increased risk of future cardiac events.
One hundred nine medically treated patients with previous Q-wave myocardial infarction underwent two exercise radionuclide angiographic studies at least 6 months apart (median, 16 months) without an intervening clinical event. Worsening exercise performance between the two studies was defined by five criteria: (1) lower (5% or more) peak exercise ejection fraction; (2) worsening peak exercise wall motion score; (3) combination of criteria 1 and 2; (4) worsening serial delta (exercise – rest) ejection fraction; or (5) increasing exercise ST-segment depression of 1mm or more. Patients were followed up for a median duration of 3.9 years after the second exercise study.
Five cardiac deaths and 10 nonfatal myocardial infarctions occurred during follow-up. A Cox proportional hazards analysis failed to show an association between any of the aforementioned variables and cardiac events. Of the 15 patients with cardiac events, 4 (27%) had a lower (5% or more) exercise ejection fraction and 2 (13%) had a worsening exercise wall motion score. Of the 94 patients without cardiac events, 37 (39%) had a lower (5% or more) exercise ejection fraction and 28 (30%) had a worsening serial exercise wall motion score (not a statistically significant difference).
Worsening exercise performance on serial exercise radionuclide angiography does not identify patients at increased risk of future cardiac events. |
| doi_str_mv | 10.1016/S0025-6196(11)63589-1 |
| format | Article |
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One hundred nine medically treated patients with previous Q-wave myocardial infarction underwent two exercise radionuclide angiographic studies at least 6 months apart (median, 16 months) without an intervening clinical event. Worsening exercise performance between the two studies was defined by five criteria: (1) lower (5% or more) peak exercise ejection fraction; (2) worsening peak exercise wall motion score; (3) combination of criteria 1 and 2; (4) worsening serial delta (exercise – rest) ejection fraction; or (5) increasing exercise ST-segment depression of 1mm or more. Patients were followed up for a median duration of 3.9 years after the second exercise study.
Five cardiac deaths and 10 nonfatal myocardial infarctions occurred during follow-up. A Cox proportional hazards analysis failed to show an association between any of the aforementioned variables and cardiac events. Of the 15 patients with cardiac events, 4 (27%) had a lower (5% or more) exercise ejection fraction and 2 (13%) had a worsening exercise wall motion score. Of the 94 patients without cardiac events, 37 (39%) had a lower (5% or more) exercise ejection fraction and 28 (30%) had a worsening serial exercise wall motion score (not a statistically significant difference).
Worsening exercise performance on serial exercise radionuclide angiography does not identify patients at increased risk of future cardiac events.</description><identifier>ISSN: 0025-6196</identifier><identifier>EISSN: 1942-5546</identifier><identifier>DOI: 10.1016/S0025-6196(11)63589-1</identifier><identifier>PMID: 9276597</identifier><identifier>CODEN: MACPAJ</identifier><language>eng</language><publisher>Rochester, MN: Elsevier Inc</publisher><subject>Aged ; Biological and medical sciences ; Cardiovascular system ; Death, Sudden, Cardiac ; Exercise Test ; Female ; Humans ; Investigative techniques of hemodynamics ; Investigative techniques, diagnostic techniques (general aspects) ; Male ; Medical sciences ; Middle Aged ; Myocardial Infarction ; Proportional Hazards Models ; Radionuclide Ventriculography ; Recurrence ; Retrospective Studies ; Risk ; Ventricular Dysfunction, Left - diagnostic imaging ; Ventricular Dysfunction, Left - physiopathology ; Ventricular Function, Left</subject><ispartof>Mayo Clinic proceedings, 1997-08, Vol.72 (8), p.711-718</ispartof><rights>1997 Mayo Foundation for Medical Education and Research</rights><rights>1997 INIST-CNRS</rights><rights>Copyright Mayo Foundation for Medical Education and Research Aug 1997</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c416t-8629269c586e35caaa267f4a7456330df62fd92d6f77191ff1adc9eed00a227e3</citedby><cites>FETCH-LOGICAL-c416t-8629269c586e35caaa267f4a7456330df62fd92d6f77191ff1adc9eed00a227e3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.proquest.com/docview/216868062?pq-origsite=primo$$EHTML$$P50$$Gproquest$$H</linktohtml><link.rule.ids>314,780,784,27923,27924,64384,64386,64388,72240</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=2785608$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/9276597$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Chaliki, Hari P.</creatorcontrib><creatorcontrib>Miller, Todd D.</creatorcontrib><creatorcontrib>Christian, Timothy F.</creatorcontrib><creatorcontrib>Bailey, Kent R.</creatorcontrib><creatorcontrib>Gibbons, Raymond J.</creatorcontrib><title>Worsening Left Ventricular Performance on Serial Exercise Radionuclide Angiography Does Not Identify High-Risk Patients</title><title>Mayo Clinic proceedings</title><addtitle>Mayo Clin Proc</addtitle><description>To determine whether worsening exercise performance on serial exercise radionuclide angiography identifies patients at increased risk of future cardiac events.
One hundred nine medically treated patients with previous Q-wave myocardial infarction underwent two exercise radionuclide angiographic studies at least 6 months apart (median, 16 months) without an intervening clinical event. Worsening exercise performance between the two studies was defined by five criteria: (1) lower (5% or more) peak exercise ejection fraction; (2) worsening peak exercise wall motion score; (3) combination of criteria 1 and 2; (4) worsening serial delta (exercise – rest) ejection fraction; or (5) increasing exercise ST-segment depression of 1mm or more. Patients were followed up for a median duration of 3.9 years after the second exercise study.
Five cardiac deaths and 10 nonfatal myocardial infarctions occurred during follow-up. A Cox proportional hazards analysis failed to show an association between any of the aforementioned variables and cardiac events. Of the 15 patients with cardiac events, 4 (27%) had a lower (5% or more) exercise ejection fraction and 2 (13%) had a worsening exercise wall motion score. Of the 94 patients without cardiac events, 37 (39%) had a lower (5% or more) exercise ejection fraction and 28 (30%) had a worsening serial exercise wall motion score (not a statistically significant difference).
Worsening exercise performance on serial exercise radionuclide angiography does not identify patients at increased risk of future cardiac events.</description><subject>Aged</subject><subject>Biological and medical sciences</subject><subject>Cardiovascular system</subject><subject>Death, Sudden, Cardiac</subject><subject>Exercise Test</subject><subject>Female</subject><subject>Humans</subject><subject>Investigative techniques of hemodynamics</subject><subject>Investigative techniques, diagnostic techniques (general aspects)</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Myocardial Infarction</subject><subject>Proportional Hazards Models</subject><subject>Radionuclide Ventriculography</subject><subject>Recurrence</subject><subject>Retrospective Studies</subject><subject>Risk</subject><subject>Ventricular Dysfunction, Left - diagnostic imaging</subject><subject>Ventricular Dysfunction, Left - physiopathology</subject><subject>Ventricular Function, Left</subject><issn>0025-6196</issn><issn>1942-5546</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1997</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNqFkU9vEzEQxS0EKmnhI1SyEEJwWLC9a3t9qqpSaKUIqpY_R8vY49RlYwd7t5Bvj9NEOXDhNNLMb56e3kPomJK3lFDx7oYQxhtBlXhN6RvR8l419BGaUdWxhvNOPEazPfIUHZZyRwiRSnUH6EAxKbiSM_T7e8oFYogLPAc_4m8QxxzsNJiMryD7lJcmWsAp4hvIwQz4_A9kGwrga-NCipMdggN8GhchLbJZ3a7x-wQFf0ojvnRVLfg1vgiL2-Y6lJ_4yoyhLssz9MSbocDz3TxCXz-cfzm7aOafP16enc4b21ExNr1giglleS-g5dYYw4T0nZEdF21LnBfMO8Wc8FJSRb2nxlkF4AgxjEloj9Crre4qp18TlFEvQ7EwDCZCmoqWirWSSFrBF_-Ad2nKsXrTjIpe9ESwCvEtZHMqJYPXqxyWJq81JXrTin5oRW8i15Tqh1b0Rvx4Jz79WILbf-1qqPeXu7sp1gw-18xD2WNM9lyQvmInWwxqYvcBsi62pmnBhQx21C6F_xj5C-CrqaM</recordid><startdate>19970801</startdate><enddate>19970801</enddate><creator>Chaliki, Hari P.</creator><creator>Miller, Todd D.</creator><creator>Christian, Timothy F.</creator><creator>Bailey, Kent R.</creator><creator>Gibbons, Raymond J.</creator><general>Elsevier Inc</general><general>Mayo Medical Ventures</general><general>Elsevier Limited</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>4U-</scope><scope>7RV</scope><scope>7T5</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>88I</scope><scope>8AF</scope><scope>8C1</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9-</scope><scope>K9.</scope><scope>KB0</scope><scope>M0R</scope><scope>M0S</scope><scope>M1P</scope><scope>M2P</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>S0X</scope><scope>7X8</scope></search><sort><creationdate>19970801</creationdate><title>Worsening Left Ventricular Performance on Serial Exercise Radionuclide Angiography Does Not Identify High-Risk Patients</title><author>Chaliki, Hari P. ; Miller, Todd D. ; Christian, Timothy F. ; Bailey, Kent R. ; Gibbons, Raymond J.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c416t-8629269c586e35caaa267f4a7456330df62fd92d6f77191ff1adc9eed00a227e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1997</creationdate><topic>Aged</topic><topic>Biological and medical sciences</topic><topic>Cardiovascular system</topic><topic>Death, Sudden, Cardiac</topic><topic>Exercise Test</topic><topic>Female</topic><topic>Humans</topic><topic>Investigative techniques of hemodynamics</topic><topic>Investigative techniques, diagnostic techniques (general aspects)</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Myocardial Infarction</topic><topic>Proportional Hazards Models</topic><topic>Radionuclide Ventriculography</topic><topic>Recurrence</topic><topic>Retrospective Studies</topic><topic>Risk</topic><topic>Ventricular Dysfunction, Left - diagnostic imaging</topic><topic>Ventricular Dysfunction, Left - physiopathology</topic><topic>Ventricular Function, Left</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Chaliki, Hari P.</creatorcontrib><creatorcontrib>Miller, Todd D.</creatorcontrib><creatorcontrib>Christian, Timothy F.</creatorcontrib><creatorcontrib>Bailey, Kent R.</creatorcontrib><creatorcontrib>Gibbons, Raymond J.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>University Readers</collection><collection>Nursing & Allied Health Database</collection><collection>Immunology Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Science Database (Alumni Edition)</collection><collection>STEM Database</collection><collection>Public Health Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>eLibrary</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>Consumer Health Database (Alumni Edition)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Consumer Health Database</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Science Database</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest Central Basic</collection><collection>SIRS Editorial</collection><collection>MEDLINE - Academic</collection><jtitle>Mayo Clinic proceedings</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Chaliki, Hari P.</au><au>Miller, Todd D.</au><au>Christian, Timothy F.</au><au>Bailey, Kent R.</au><au>Gibbons, Raymond J.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Worsening Left Ventricular Performance on Serial Exercise Radionuclide Angiography Does Not Identify High-Risk Patients</atitle><jtitle>Mayo Clinic proceedings</jtitle><addtitle>Mayo Clin Proc</addtitle><date>1997-08-01</date><risdate>1997</risdate><volume>72</volume><issue>8</issue><spage>711</spage><epage>718</epage><pages>711-718</pages><issn>0025-6196</issn><eissn>1942-5546</eissn><coden>MACPAJ</coden><abstract>To determine whether worsening exercise performance on serial exercise radionuclide angiography identifies patients at increased risk of future cardiac events.
One hundred nine medically treated patients with previous Q-wave myocardial infarction underwent two exercise radionuclide angiographic studies at least 6 months apart (median, 16 months) without an intervening clinical event. Worsening exercise performance between the two studies was defined by five criteria: (1) lower (5% or more) peak exercise ejection fraction; (2) worsening peak exercise wall motion score; (3) combination of criteria 1 and 2; (4) worsening serial delta (exercise – rest) ejection fraction; or (5) increasing exercise ST-segment depression of 1mm or more. Patients were followed up for a median duration of 3.9 years after the second exercise study.
Five cardiac deaths and 10 nonfatal myocardial infarctions occurred during follow-up. A Cox proportional hazards analysis failed to show an association between any of the aforementioned variables and cardiac events. Of the 15 patients with cardiac events, 4 (27%) had a lower (5% or more) exercise ejection fraction and 2 (13%) had a worsening exercise wall motion score. Of the 94 patients without cardiac events, 37 (39%) had a lower (5% or more) exercise ejection fraction and 28 (30%) had a worsening serial exercise wall motion score (not a statistically significant difference).
Worsening exercise performance on serial exercise radionuclide angiography does not identify patients at increased risk of future cardiac events.</abstract><cop>Rochester, MN</cop><pub>Elsevier Inc</pub><pmid>9276597</pmid><doi>10.1016/S0025-6196(11)63589-1</doi><tpages>8</tpages></addata></record> |
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| ispartof | Mayo Clinic proceedings, 1997-08, Vol.72 (8), p.711-718 |
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| subjects | Aged Biological and medical sciences Cardiovascular system Death, Sudden, Cardiac Exercise Test Female Humans Investigative techniques of hemodynamics Investigative techniques, diagnostic techniques (general aspects) Male Medical sciences Middle Aged Myocardial Infarction Proportional Hazards Models Radionuclide Ventriculography Recurrence Retrospective Studies Risk Ventricular Dysfunction, Left - diagnostic imaging Ventricular Dysfunction, Left - physiopathology Ventricular Function, Left |
| title | Worsening Left Ventricular Performance on Serial Exercise Radionuclide Angiography Does Not Identify High-Risk Patients |
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