Interactions of the Nonsedating Antihistamine Loratadine with a Kv1.5-Type Potassium Channel Cloned from Human Heart

The use of nonsedating antihistamines may, on rare occasions, be associated with cardiac arrhythmias. This could be due to blockade of voltage-dependent K+ channels in the heart, leading to a prolongation in repolarization in the human myocardium. For this reason, we examined the effects of the nons...

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Veröffentlicht in:	Molecular pharmacology 1997-08, Vol.52 (2), p.314-322
Hauptverfasser:	Lacerda, Antonio E., Roy, Mary-Louise, Lewis, Eric W., Rampe, David
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cell Line Humans Ion Channel Gating - drug effects Kv1.5 Potassium Channel Loratadine - chemistry Mice Patch-Clamp Techniques Potassium Channels - drug effects Potassium Channels, Voltage-Gated Recombinant Proteins
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