Docosahexaenoic and eicosapentaenoic acids inhibit in vitro human lymphocyte proliferation induced by allogenic cells
During the last decade, there has been great interet in studying the effects of different types of dietary fatty acids on the immune system. Much of this interest has focused on polyunsaturated fatty acids (PUFAs). We and other investigators have previously shown that ω3 PUFAs are able to inhibit ly...
Gespeichert in:
| Veröffentlicht in: | Transplantation proceedings 1997-08, Vol.29 (5), p.2397-2397 |
|---|---|
| Hauptverfasser: | , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 2397 |
|---|---|
| container_issue | 5 |
| container_start_page | 2397 |
| container_title | Transplantation proceedings |
| container_volume | 29 |
| creator | Khalfoun, B. Gruel, Y. Bardos, P. Lebranchu, Y. |
| description | During the last decade, there has been great interet in studying the effects of different types of dietary fatty acids on the immune system. Much of this interest has focused on polyunsaturated fatty acids (PUFAs). We and other investigators have previously shown that ω3 PUFAs are able to inhibit lymphocyte proliferation in response to mitogens and to immobilized anti-CD3. This effect is not due to eicosanoid and peroxide synthesis and could not be explained only by a mechanism preventing interleukin 2 synthesis. To extend our understanding of the effect of ω3 PUFAs on the immune system, we examined the in vitro effects of doco sa hexaenoic acid (DHA) and eicosapentaenoic acid (EPA) on human lymphocyte proliferation in response to alloantigens. |
| doi_str_mv | 10.1016/S0041-1345(97)00417-X |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_79236500</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S004113459700417X</els_id><sourcerecordid>79236500</sourcerecordid><originalsourceid>FETCH-LOGICAL-c389t-d06fe3684964afe844439ff34f178c59ea79d3f71dabbedee84a662328da5bb73</originalsourceid><addsrcrecordid>eNqFkMFu3CAQQFHVKN0m_YRIHKKqPTgFg405VVXapJEi5dBUyg1hGLpUNmzBjrJ_H5zd7LWn0cy8GYaH0BklF5TQ9ssvQjitKOPNJyk-L4moHt6gFe0Eq-q2Zm_R6oC8Q-9z_ktKXnN2jI5lLYgQ3QrN36OJWa_hSUOI3mAdLAa_1DYQptei8TZjH9a-91OJ-NFPKeL1POqAh-24WUeznQBvUhy8g6QnH0Ph7GzA4n6L9TDEPxDKKgPDkE_RkdNDhg_7eIJ-X_24v_xZ3d5d31x-u60M6-RUWdI6YG3HZcu1g45zzqRzjDsqOtNI0EJa5gS1uu_BQiF0W35ed1Y3fS_YCfq421sO-zdDntTo83KBDhDnrISsWdsQUsBmB5oUc07g1Cb5UaetokQtutWLbrW4VFKoF93qocyd7R-Y-xHsYWrvt_TP932djR5c0sH4fMBq0RHKWMG-7jAoMh49JJWNh1Dk-QRmUjb6_xzyDDLrn3g</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>79236500</pqid></control><display><type>article</type><title>Docosahexaenoic and eicosapentaenoic acids inhibit in vitro human lymphocyte proliferation induced by allogenic cells</title><source>MEDLINE</source><source>Elsevier ScienceDirect Journals</source><creator>Khalfoun, B. ; Gruel, Y. ; Bardos, P. ; Lebranchu, Y.</creator><creatorcontrib>Khalfoun, B. ; Gruel, Y. ; Bardos, P. ; Lebranchu, Y.</creatorcontrib><description>During the last decade, there has been great interet in studying the effects of different types of dietary fatty acids on the immune system. Much of this interest has focused on polyunsaturated fatty acids (PUFAs). We and other investigators have previously shown that ω3 PUFAs are able to inhibit lymphocyte proliferation in response to mitogens and to immobilized anti-CD3. This effect is not due to eicosanoid and peroxide synthesis and could not be explained only by a mechanism preventing interleukin 2 synthesis. To extend our understanding of the effect of ω3 PUFAs on the immune system, we examined the in vitro effects of doco sa hexaenoic acid (DHA) and eicosapentaenoic acid (EPA) on human lymphocyte proliferation in response to alloantigens.</description><identifier>ISSN: 0041-1345</identifier><identifier>EISSN: 1873-2623</identifier><identifier>DOI: 10.1016/S0041-1345(97)00417-X</identifier><identifier>PMID: 9270778</identifier><identifier>CODEN: TRPPA8</identifier><language>eng</language><publisher>New York, NY: Elsevier Inc</publisher><subject>Animals ; Biological and medical sciences ; Cell Division - immunology ; Cells, Cultured ; Docosahexaenoic Acids - pharmacology ; Eicosapentaenoic Acid - pharmacology ; Fundamental and applied biological sciences. Psychology ; Fundamental immunology ; Humans ; Isoantigens - immunology ; Lymphocyte Activation - drug effects ; Lymphocyte Activation - immunology ; Lymphocytes - immunology ; Lymphocytes - pathology ; Tissue, organ and graft immunology</subject><ispartof>Transplantation proceedings, 1997-08, Vol.29 (5), p.2397-2397</ispartof><rights>1997</rights><rights>1997 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c389t-d06fe3684964afe844439ff34f178c59ea79d3f71dabbedee84a662328da5bb73</citedby><cites>FETCH-LOGICAL-c389t-d06fe3684964afe844439ff34f178c59ea79d3f71dabbedee84a662328da5bb73</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S004113459700417X$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>309,310,314,776,780,785,786,3537,23909,23910,25118,27901,27902,65306</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=2780133$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/9270778$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Khalfoun, B.</creatorcontrib><creatorcontrib>Gruel, Y.</creatorcontrib><creatorcontrib>Bardos, P.</creatorcontrib><creatorcontrib>Lebranchu, Y.</creatorcontrib><title>Docosahexaenoic and eicosapentaenoic acids inhibit in vitro human lymphocyte proliferation induced by allogenic cells</title><title>Transplantation proceedings</title><addtitle>Transplant Proc</addtitle><description>During the last decade, there has been great interet in studying the effects of different types of dietary fatty acids on the immune system. Much of this interest has focused on polyunsaturated fatty acids (PUFAs). We and other investigators have previously shown that ω3 PUFAs are able to inhibit lymphocyte proliferation in response to mitogens and to immobilized anti-CD3. This effect is not due to eicosanoid and peroxide synthesis and could not be explained only by a mechanism preventing interleukin 2 synthesis. To extend our understanding of the effect of ω3 PUFAs on the immune system, we examined the in vitro effects of doco sa hexaenoic acid (DHA) and eicosapentaenoic acid (EPA) on human lymphocyte proliferation in response to alloantigens.</description><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Cell Division - immunology</subject><subject>Cells, Cultured</subject><subject>Docosahexaenoic Acids - pharmacology</subject><subject>Eicosapentaenoic Acid - pharmacology</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Fundamental immunology</subject><subject>Humans</subject><subject>Isoantigens - immunology</subject><subject>Lymphocyte Activation - drug effects</subject><subject>Lymphocyte Activation - immunology</subject><subject>Lymphocytes - immunology</subject><subject>Lymphocytes - pathology</subject><subject>Tissue, organ and graft immunology</subject><issn>0041-1345</issn><issn>1873-2623</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1997</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkMFu3CAQQFHVKN0m_YRIHKKqPTgFg405VVXapJEi5dBUyg1hGLpUNmzBjrJ_H5zd7LWn0cy8GYaH0BklF5TQ9ssvQjitKOPNJyk-L4moHt6gFe0Eq-q2Zm_R6oC8Q-9z_ktKXnN2jI5lLYgQ3QrN36OJWa_hSUOI3mAdLAa_1DYQptei8TZjH9a-91OJ-NFPKeL1POqAh-24WUeznQBvUhy8g6QnH0Ph7GzA4n6L9TDEPxDKKgPDkE_RkdNDhg_7eIJ-X_24v_xZ3d5d31x-u60M6-RUWdI6YG3HZcu1g45zzqRzjDsqOtNI0EJa5gS1uu_BQiF0W35ed1Y3fS_YCfq421sO-zdDntTo83KBDhDnrISsWdsQUsBmB5oUc07g1Cb5UaetokQtutWLbrW4VFKoF93qocyd7R-Y-xHsYWrvt_TP932djR5c0sH4fMBq0RHKWMG-7jAoMh49JJWNh1Dk-QRmUjb6_xzyDDLrn3g</recordid><startdate>19970801</startdate><enddate>19970801</enddate><creator>Khalfoun, B.</creator><creator>Gruel, Y.</creator><creator>Bardos, P.</creator><creator>Lebranchu, Y.</creator><general>Elsevier Inc</general><general>Elsevier Science</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19970801</creationdate><title>Docosahexaenoic and eicosapentaenoic acids inhibit in vitro human lymphocyte proliferation induced by allogenic cells</title><author>Khalfoun, B. ; Gruel, Y. ; Bardos, P. ; Lebranchu, Y.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c389t-d06fe3684964afe844439ff34f178c59ea79d3f71dabbedee84a662328da5bb73</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1997</creationdate><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Cell Division - immunology</topic><topic>Cells, Cultured</topic><topic>Docosahexaenoic Acids - pharmacology</topic><topic>Eicosapentaenoic Acid - pharmacology</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Fundamental immunology</topic><topic>Humans</topic><topic>Isoantigens - immunology</topic><topic>Lymphocyte Activation - drug effects</topic><topic>Lymphocyte Activation - immunology</topic><topic>Lymphocytes - immunology</topic><topic>Lymphocytes - pathology</topic><topic>Tissue, organ and graft immunology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Khalfoun, B.</creatorcontrib><creatorcontrib>Gruel, Y.</creatorcontrib><creatorcontrib>Bardos, P.</creatorcontrib><creatorcontrib>Lebranchu, Y.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Transplantation proceedings</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Khalfoun, B.</au><au>Gruel, Y.</au><au>Bardos, P.</au><au>Lebranchu, Y.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Docosahexaenoic and eicosapentaenoic acids inhibit in vitro human lymphocyte proliferation induced by allogenic cells</atitle><jtitle>Transplantation proceedings</jtitle><addtitle>Transplant Proc</addtitle><date>1997-08-01</date><risdate>1997</risdate><volume>29</volume><issue>5</issue><spage>2397</spage><epage>2397</epage><pages>2397-2397</pages><issn>0041-1345</issn><eissn>1873-2623</eissn><coden>TRPPA8</coden><abstract>During the last decade, there has been great interet in studying the effects of different types of dietary fatty acids on the immune system. Much of this interest has focused on polyunsaturated fatty acids (PUFAs). We and other investigators have previously shown that ω3 PUFAs are able to inhibit lymphocyte proliferation in response to mitogens and to immobilized anti-CD3. This effect is not due to eicosanoid and peroxide synthesis and could not be explained only by a mechanism preventing interleukin 2 synthesis. To extend our understanding of the effect of ω3 PUFAs on the immune system, we examined the in vitro effects of doco sa hexaenoic acid (DHA) and eicosapentaenoic acid (EPA) on human lymphocyte proliferation in response to alloantigens.</abstract><cop>New York, NY</cop><pub>Elsevier Inc</pub><pmid>9270778</pmid><doi>10.1016/S0041-1345(97)00417-X</doi><tpages>1</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0041-1345 |
| ispartof | Transplantation proceedings, 1997-08, Vol.29 (5), p.2397-2397 |
| issn | 0041-1345 1873-2623 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_79236500 |
| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Animals Biological and medical sciences Cell Division - immunology Cells, Cultured Docosahexaenoic Acids - pharmacology Eicosapentaenoic Acid - pharmacology Fundamental and applied biological sciences. Psychology Fundamental immunology Humans Isoantigens - immunology Lymphocyte Activation - drug effects Lymphocyte Activation - immunology Lymphocytes - immunology Lymphocytes - pathology Tissue, organ and graft immunology |
| title | Docosahexaenoic and eicosapentaenoic acids inhibit in vitro human lymphocyte proliferation induced by allogenic cells |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-07T02%3A36%3A31IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Docosahexaenoic%20and%20eicosapentaenoic%20acids%20inhibit%20in%20vitro%20human%20lymphocyte%20proliferation%20induced%20by%20allogenic%20cells&rft.jtitle=Transplantation%20proceedings&rft.au=Khalfoun,%20B.&rft.date=1997-08-01&rft.volume=29&rft.issue=5&rft.spage=2397&rft.epage=2397&rft.pages=2397-2397&rft.issn=0041-1345&rft.eissn=1873-2623&rft.coden=TRPPA8&rft_id=info:doi/10.1016/S0041-1345(97)00417-X&rft_dat=%3Cproquest_cross%3E79236500%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=79236500&rft_id=info:pmid/9270778&rft_els_id=S004113459700417X&rfr_iscdi=true |